San Francisco 49ers vs Las Vegas Raiders Odds & Picks – Preseason Week 1 Predictions

• The Las Vegas Raiders host the San Francisco 49ers in NFL preseason Week 1 action
• The 49ers have topped Vegas in four straight preseason games
• Read on for all the odds and trends ahead of Sunday afternoon’s matchup at Allegiant Stadium

The NFL preseason Week 1 schedule draws to a close on Sunday afternoon, as the Las Vegas Raiders play host to the San Francisco 49ers.

The contest is expected to mark the first game appearance by Trey Lance since the Niners quarterback suffered a season-ending injury a year go, but it remains unclear if Raiders pivot Jimmy Garoppolo will see any action against his former 49ers teammates.

San Francisco 49ers vs Las Vegas Raiders Odds

The 49ers have emerged as 4-point road favorites on the NFL preseason odds at top online sportsbooks. The Raiders lag as +150 moneyline underdogs, while the total is pegged at just 36.

Kickoff is set for 4:00pm at Allegiant Stadium in Las Vegas, with all three game action televised on NFL Network.

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Odds as of Saturday, August 12, 2023 at FanDuel Sportsbook. Claim the FanDuel promo code to bet on 49ers vs Raiders in NFL preseason.

49ers vs Raiders Recent History

The 49ers enter Sunday afternoon’s contest in Sin City enjoying a four-game SU win streak against the Raiders in preseason play. These two teams last met in August action two years ago, with the 49ers rolling to an easy 34-10 win.

Overall, San Francisco has held the Raiders to just 13 total points over their past two preseason clashes. However, the 49ers have tallied just one SU win in four August road dates with the Raiders since 1999.

Recent preseason meetings between these teams have tended to be high scoring, with the total topping 40 four times during a 4-2 run for the OVER.

San Francisco 49ers Betting Outlook

All eyes have been on quarterback Trey Lance during this week’s joint practices with the Raiders. The 23-year-old has shown no ill effects from the ankle injury that ended his season last September, and took the most reps and the three passers battling for the job as Brock Purdy’s backup, including reclamation project Sam Darnold, who is expect to take over under center in the second half.

#49ers QB’s Trey Lance will play the 1st Half and Sam Darnold will play the 2nd half Vs #Raiders.

Who do you think will perform better & PREDICT THEIR STAT LINES?👀👀👀 pic.twitter.com/XDhmtYC3T2

— 49ers & NFL News 24/7 (@49ersSportsTalk) August 12, 2023

Opportunity could knock for second-year rusher Jordan Mason in Sunday’s contest. Mason emerged as one of the surprises of last year’s training camp, earning a spot on the squad as an undrafted rookie. And while he saw limited action last season, he could enjoy an extended audition on Sunday considering the injury owes that continues to dog veteran Elijah Mitchell.

Las Vegas Raiders Betting Outlook

After parting ways with Derek Carr last season, the Raiders filled the void under center with their offseason acquisition of Jimmy Garoppolo, and it would certainly add to the intrigue of this preseason opener if the Raiders elect to start Jimmy G against his former teammates. Garoppolo endured a tough season in San Francisco last year.

With Trey Lance poised to be the starter, it appeared that Jimmy G’s Niner days were numbered. However, with Lance getting injured, he briefly returned to the starter’s role before suffering a season-ending injury of his own that propelled Brock Purdy to the top of the depth chart, and heralded the end of Jimmy G’s tenure with the 49ers.

Chase Garbers is back—does this mean we won't be seeing Jimmy Garoppolo in the Las Vegas Raiders preseason? It's a safe bet if you're a gambling man, no?#RaiderNation | #NFL https://t.co/zCdiSgcFTB

— RaiderRamble.com™ (@TheRaiderRamble) August 4, 2023

Of course, Garoppolo remains an injury risk, and if the Raiders decide to keep Garoppolo off the gridiron, look for Chase Garbers to see action on Sunday. Signed as an undrafted rookie a year ago, Garbers served as Jarrett Stidham’s backup for Vegas’ final two games last season, and needs to produce in whatever preseason opportunities he has to save his job.

49ers vs Raiders Prediction

The opening game of the preseason schedule is always entertaining for fans looking to evaluate the talent further down the depth chart.

But while the 49ers are unlikely to have many starters in uniform, let alone in game action, there is plenty of competition up and down the Raiders roster that makes them appealing as betting underdogs.

The Pick: Raiders +4 (-110); OVER 36 (-110)