Chelsea vs Lille Odds & Prediction – Champions League Round of 16 Leg 1

By Gary Gowers in Soccer News
Published:

- It’s Chelsea vs Lille in the Champions League on Tuesday, February 22 at 3:00 pm ET
- Reigning UCL champions Chelsea start this round-of-16 first-leg tie as favorites
- We preview the game, look at the Chelsea vs Lille odds, and offer some picks below
It is Chelsea vs Lille in the first-leg of their UEFA Champions League tie on Tuesday, February 22 at 3:00 pm ET at Stamford Bridge. The Blues of West London are the reigning UCL champions but only qualified for the knockout phase by finishing second in Group H, while the Ligue 1 came top in Group G.
We preview Chelsea vs Lille and offer below the best picks for this huge UCL clash.
Chelsea vs Lille Odds
Matchup | Spread | Moneyline | Total |
---|---|---|---|
Chelsea vs Lille | CHE -1.5 (-104) | LIL +1.5 (-115) | CHE -315 | DRAW +425 | LIL +950 | Ov 2.5 (-137) | Un 1.5 (+112) |
Odds as of February 21 at Barstool Sportsbook

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The bookies expect Chelsea to win this comfortably and have made them massive -315 favorites in Champions League odds with an implied win probability of 75.9%. Lille at +950 for the win has an implied probability of just 9.5%, while under 2.5 goals is interestingly still in plus money at +112.
If you’re new to this sport and need advice on soccer betting’s pros and cons, there are plenty of directions you can go to betting this match and others.
Chelsea on Five-Game Winning Run
Chelsea’s defense of their UCL title got off to a relatively smooth start with comfortable qualification for the knockout phase. Although they did finish second in Group H behind Juventus, who won five of their six games. Chelsea’s only slip-ups were an away defeat to Juve and a 3-3 draw with Zenit St Petersburg at Stamford Bridge on the final matchday.
Love. 🥰#CryChe pic.twitter.com/J6g2qR9Ld3
— Chelsea FC (@ChelseaFC) February 19, 2022
It has been a good start to 2022 for Thomas Tuchel’s men, who have already wrapped up the World Club Championship, and they come into this crucial tie off the back of a five-game winning run across all competitions. At the weekend, despite not hitting anything like their top form, they found a way to get past a spirited Crystal Palace team –Â Hakim Ziyech scoring the all-important goal in the 89th-minute.
Outstanding Record at the Bridge
Despite being the current holders of the Champions League trophy, Chelsea is not among the favorites for this season’s competition – Man City, Bayern Munch and Liverpool are all more fancied – but no way should they be disregarded. Tuchel’s squad has enough quality to win it twice in two seasons.
Magician at work! 🪄#CryChe pic.twitter.com/40RNWGhPwF
— Chelsea FC (@ChelseaFC) February 19, 2022
One massive advantage in Chelsea’s favor for Tuesday night and looking further ahead is their outstanding form at Stamford Bridge. They are undefeated on home turf since September and have won their last four Champions League ties at the bridge without conceding a single goal. In the Premier League, they lie third but 13 points adrift of the leaders, Man City
Chelsea vs Lille Head-to-Head Stats
4-1-1 | UCL group stage record | 3-2-1 |
13 | Goals for | 7 |
4 | Goals against | 4 |
2nd | Position in group | 1st |
D-W-W-W-W-W | Form guide (all competitions) | D-W-L-L-W-D |

Lille Overcome a Horror Start
Lille qualified for the knockout phase the hard way after taking just two points from their opening three UCL games, but with an exit from the competition looking likely they found some form when they needed it most in their final three group games.
Our last #UCL goal at Stamford Bridge 💥
🇫🇷 Loïc Rémy#LOSC | 🔜 #CHELOSC | @ChampionsLeague pic.twitter.com/HtB7vGjbvY
— LOSC (@LOSC_EN) February 20, 2022
Successive wins over Sevilla, Red Bull Salzburg and Wolfsburg with the pressure gauge on 11 saw Les Dogues not only qualify for the next phase but do so as group winners – pushing Salzburg down to second in the process with their Matchday 6 win away at Wolfsburg.
No Ligue 1 Title for Lille
Yet it’s not been plaining sailing on the domestic front for Lille, who will not be successfully defending their Ligue 1 title. After surprisingly winning the crown last season, they currently languish down in 11th place and manager Jocelyn Gourvennec saw his team warm-up for the Chelsea game with a disappointing 0-0 draw at home against Metz at the weekend.
Just touched down in London town 🇬🇧#LOSC | 🔜 #CHELOSC | #UCL pic.twitter.com/DtIaNSygLF
— LOSC (@LOSC_EN) February 21, 2022
Lille have reached the last-16 of the UCL just once before – in 2006-07 when they were knocked out by Manchester United. And when they last faced Chelsea in this competition, in the 2019-20 group stages, they suffered two 2-1 defeats.
Chelsea vs Lille Picks
Les Dogues’ poor form since the start of 2022 makes it very difficult to make a case for anything other than a Chelsea win. Even though the Blues’ five consecutive wins have been achieved without hitting top form. But, the pressure that comes with defending the Champions League trophy cannot be overestimated. So while I believe Chelsea will get the job done over two legs, there is, for me, value here in the draw.
Picks: Chelsea and Lille to draw (+425)
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Sports Writer
Once just a sports fanatic, fan-turned-writer Gary Gowers has been featured on European television and radio networks to discuss several professional football clubs. His work can be found in an assortment of publications like The Metro, MyFootballWriter.com, and BBC Radio Norfolk.