Liverpool vs Benfica Odds, Preview & Best Bet – Champions League Quarterfinals Leg 2

• Six-time winner Liverpool hosts historic twice-champion Benfica at 3:00 pm ET on Wednesday
• Jurgen Klopp’s rampant side holds a 3-1 lead after a dominant performance in the first leg in Lisbon and are -345 favorites on the moneyline
• See all odds, best bets and preview for Liverpool vs Benfica in the Champions League Quarterfinals Leg 2

Liverpool is comfortably in the driving seat as it prepares to host Benfica in the Champions League on Wednesday. Read on for our Liverpool vs Benfica prediction here.

Jurgen Klopp’s team holds a 3-1 first leg lead heading into the last eight return meeting at Anfield.

A semifinal place against Bayern Munich or Villarreal awaits.

Liverpool vs Benfica Odds

Odds as of April 12 at Barstool

Certainly, then, it is no surprise that Barstool Sportsbook makes Liverpool a huge favorite in the Champions League odds for a home win against Portuguese giants Benfica at -345.

The visitor, meanwhile, is priced as a very wide outsider at +900 with the draw after 90 minutes also considered highly unlikely at +510.

The kick-off is at 3:00 pm ET.

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Over/Under and Spread

Meanwhile, there are goals to be expected with the Over/Under set at 3.5. However, the Under is still the favored option at -130 odds. Liverpool are also favored to win by more than one goal with the -1.5 Asian handicap (spread) favored at -125 odds.

Liverpool vs Benfica Prediction for Leg 2 Quarterfinal

Indeed, Liverpool is in pursuit of an extraordinary Quadruple season.

As well as being among the leading contenders to win the UCL, it is also in a tight race at the top of the English Premier League – just one point behind leader Manchester City.

Reds in Mighty EPL Draw with Man City

Those two sides were involved in a titanic 2-2 draw at the Etihad Stadium last Sunday which was hailed as one of the finest games in the history of the EPL.

It ended with both sides mentioned by some observers as the best to compete in the English top flight ever.

Liverpool is, furthermore, also involved in an FA Cup semifinal against City at Wembley on Sunday.

Moreover, it has already lifted England’s EFL League Cup after a win on penalties against Chelsea in the Wembley final.

Frankly, all of this underlines the fact that Liverpool is among the most powerful teams in Europe just now – and is in a rampant mood of form to boot.

🗣 “Really aggressive in a football sense.”

Jürgen Klopp on the biggest threat Liverpool face against Benfica. pic.twitter.com/tW5ePVrLGk

— Football Daily (@footballdaily) April 12, 2022

Diogo Jota Goalscorer Odds

It would certainly be more productive to look at a prop selection here.

Diogo Jota has scored in all three of Liverpool’s most recent league fixtures. He was also previously on target in the FA Cup quarterfinal victory against Nottingham Forest on March 20.

At +420, he surely looks an attractive prop to be the first goalscorer – although, additionally, the prolific Mo Salah is the favorite for that target at +310.

Furthermore, Jota is at +105 simply to get on the scoresheet, which is also intriguing – along with Sadio Mane at +143.

At -143, Salah is obviously not such a potentially profitable option simply to find the net at any time.

Liverpool vs Benfica Statistics

*Stats from UCL 2021-22.

Meanwhile, Benfica is in third place in the Portuguese league. And it has no hopes of lifting the title as it sits 15 points behind leader Porto.

Liverpool emphatically took quick command of the first leg meeting as it stormed into a two-goal lead thanks to strikes from Ibrahima Konate and Mane.

Nunez Claimed Solitary Goal for Benfica

Upcoming star Darwin Nunez pulled one back for Benfica.

However, Liverpool was assured of a comfortable lead to take back home thanks to a further goal from Luis Diaz.

There was a significant possession advantage of 64 percent to 36 percent in Liverpool’s favor in the first leg at the Estadio Da Luz.

Additionally, Liverpool had 18 goal attempts against nine for the home side.

So it is consequently easy to see why Liverpool is so heavily favored.

There were officially 81 dangerous attacks for Liverpool against just 28 for Benfica.

Liverpool’s EPL league form has been stupendous

There was a 3-1 defeat of Belenenses for Benfica in Portugal last weekend following a 3-2 defeat at Braga.

Liverpool’s league form has been stupendous with the draw at Manchester City last weekend ending a run of 10 straight wins.

Liverpool learn Benfica's asking price for Darwin Nunez, it has been claimed

Latest #LFC transfer rumourshttps://t.co/yKYIy810pY pic.twitter.com/oE8ZTk7YeH

— Liverpool FC News (@LivEchoLFC) April 11, 2022

Benfica overcame PSV Eindhoven 2-1 on aggregate in the last 16.

Meanwhile, Liverpool was a 2-1 aggregate winner against Inter Milan – although it lost the second leg 1-0 at home.

Europa League Meeting In 2010

These teams previously met in the Europa League quarterfinal in 2010.

Benfica was a 2-1 winner at home before Liverpool triumphed 4-1 at Anfield.

🤜🤛 Final training ahead of #LIVSLB!#UCL #WeAreBenfica pic.twitter.com/9FRLYEBwlN

— SL Benfica (@slbenfica_en) April 12, 2022

Indeed, Benfica has won just one quarterfinal away leg in Europe this century.

Liverpool vs Benfica Pick

Furthermore, it has been 20 years since the six-time winner of the competition Liverpool was eliminated from a knockout tie, having won the first leg.

Liverpool have many contenders to find the back of the net on Wednesday. But Jota has been in fine form and could offer some value. Jota has scored a goal in five of his past seven matches. He found the scoresheet on Sunday in the crucial 2-2 draw with Man City.

So, in conclusion, Liverpool should be in for an untroubled night as it seeks to repeat its most recent UCL triumph of 2019, but backing a goalscorer prop may be the better value approach.

Pick: Diogo Jota First Goalscorer (+420)