White Sox vs Mariners Odds & Picks (Sep. 7)

By Quinn Allen in MLB Baseball
Published:

- The White Sox face the Mariners on Wednesday, September 7th
- Seattle currently sits in a Wild Card spot, while Chicago has a lot of work to do to reach the postseason
- The White Sox vs Mariners odds and betting prediction can be found below
Wednesday will be the rubber match of a three-game set between the Chicago White Sox (68-67, 34-31 away) and the Seattle Mariners (76-59, 35-29 home) at T-Mobile Park. The first pitch is scheduled for 4:10 pm ET.
The White Sox will likely hand Michael Kopech the ball here as he returns from a minor knee ailment, while the M’s counter with their ace and trade deadline acquisition, Luis Castillo.
White Sox vs Mariners Odds
Team | Moneyline | Runline | Total |
---|---|---|---|
Chicago White Sox | +162 | +1.5 (-130) | Ov 7.5 (+105) |
Seattle Mariners | -195 | -1.5 (+110) | Un 7.5 (-125) |
Odds as of September 6th at Caesars Sportsbook. Get Caesars Sportsbook promo code.
The Mariners are -195 home favorites with Chicago a +162 underdog. The run total is sitting at just 7.5 and with the under favored at -125.

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Chicago vs Seattle Probable Pitchers
Chicago hasn’t officially announced that Kopech will start here, but all signs point to it after a very good bullpen session on Sunday. He’s been out since August 22nd when the hard-throwing righty exited early with knee soreness. When healthy, Kopech is dealing.
Luis Robert kept it short, sweet and in English about his wrist.
“Very good. I’m good.”
Michael Kopech expects he’ll have a pitch limit tomorrow but doesn’t know what it is. Said his leg issue went away a few days after his Kansas City start.
— James Fegan (@JRFegan) September 6, 2022
The 26-year-old is 4-9 with a 3.58 ERA in 23 starts this season, striking out 98 in 110.2 innings. The 55 walks are slightly concerning, but he’s usually able to pitch out of trouble. Kopech has yet to face the Mariners in 2022. In fact, he’s only pitched two innings against them.
Kopech vs Castillo
4-9 | Record | 6-5 |
3.58 | ERA | 2.72 |
110.2 | Innings Pitched | 122.2 |
98 | Strikeouts | 133 |
55 | BB | 37 |
Since arriving in Seattle, Castillo is fully living up to the hype. He’s 2-1 with a 2.39 ERA in six outings with the M’s, collecting 43 punchouts in 37.2 frames and holding opponents to a .227 average. As you can see above, his ERA is not too shabby for the season as a whole too, sitting at 2.72.
Luis Castillo is still nasty 🤢 pic.twitter.com/9N3sgRqvIz
— Votto De La Cruz (@EvilJoeyVotto) September 3, 2022
Castillo’s last outing was yet another gem, grabbing his sixth victory after tossing six innings of scoreless baseball vs. Cleveland, allowing only five hits in the process. He’s not too familiar with the White Sox, but Castillo’s lone career appearance went well, surrendering one run in 6.2 innings.
Crunch Time for Chicago
Every single game matters for Chicago right now and at this rate, it appears their best shot at actually making the postseason will be through the division. The AL Central is extremely tight, with the White Sox sitting just two games back of Cleveland for first place. Minnesota trails the Guardians by one game. It’s truly a toss-up as to who could be crowned champions.
Elvis has left the building.#ChangeTheGame | @NBCSChicago pic.twitter.com/2EMlZRCwZ8
— Chicago White Sox (@whitesox) September 5, 2022
The absence of manager Tony La Russa doesn’t exactly help Chicago, though. He’s currently away from the team due to a medical issue and with the most important few weeks of the season approaching, it would be ideal to have their boss back.
Mariners in Great Shape
There are still a lot of games left, but it’s looking more and more like Seattle’s postseason drought will finally end. They’re second in the AL Wild Card just behind the Rays and are playing fantastic baseball at the moment, posting an 8-2 record in their last 10 games.
The No-Fly Zone is in full effect 🙅♂️ pic.twitter.com/opTYijJscU
— Seattle Mariners (@Mariners) September 6, 2022
Before Chicago came to town, the M’s swept the Guardians on the road and also won three straight against the Tigers. With Castillo on the bump here, Seattle will be lacking no shortage of confidence he can guide them to another win. Hopefully, AL Rookie of the Year odds favorite (-500) will provide some offense.
CHW vs SEA – Last 10 Games
Date | Home Team | Away Team | Score |
---|---|---|---|
09/05/22 | Mariners | White Sox | CHW, 3-2 |
04/14/22 | White Sox | Mariners | SEA, 5-1 |
04/13/22 | White Sox | Mariners | CHW, 6-4 |
04/12/22 | White Sox | Mariners | CHW, 3-2 |
06/27/21 | White Sox | Mariners | CHW, 7-5 |
06/26/21 | White Sox | Mariners | SEA, 3-2 |
06/25/21 | White Sox | Mariners | SEA, 9-3 |
04/07/21 | Mariners | White Sox | SEA, 8-4 |
04/06/21 | Mariners | White Sox | CHW, 10-4 |
04/05/21 | Mariners | White Sox | CHW, 6-0 |
White Sox vs Mariners Pick
I just can’t bet against Castillo. He’s honestly just dealing every time he takes the mound and it will continue in the series finale. Take Seattle on the moneyline.
Pick: Mariners moneyline (-195)

Sports Writer
Quinn Allen is a sports journalist, with a background and education in broadcast journalism (BCIT '17). He is a full-time associate editor at ClutchPoints by day, where he writes about soccer, baseball, basketball, football, and more. At night, Quinn is a frequent contributor at SBD.