Lipscomb vs Iowa State Betting Predictions & Player Props

• Lipscomb meets Iowa State in the first round of the March Madness tournament on Friday, March 21
• Lipscomb has won six straight games
• Check out all the Lipscomb vs Iowa State odds, with picks and betting predictions

The No. 3 Iowa State Cyclones (24-9 SU, 19-14 ATS) face off against the No. 14 Lipscomb Bisons in the first round of the March Madness tournament on Friday in Milwaukee. Iowa State finished the regular season on a 6-3 SU run before falling to BYU in the Big 12 tournament. Lipscomb has won 10 of its last 11 games and is red-hot entering March Madness. Get your bets in before tipoff as Lipscomb vs Iowa State gets underway at 1:30 pm on Friday. Check out my Lipscomb vs Iowa State predictions and player-prop picks, below.

Lipscomb vs Iowa State Prediction

Iowa State is a behemoth heading into the March Madness tournament. Were it not for injuries, the Cyclones would be poised for a deep tournament run. However, even without the skills of scoring guard Keshon Gilbert, the Cyclones are a dangerous squad. Iowa State sit 10th in KenPom’s rankings with the 21st ranked offense and ninth ranked defense. They force turnovers at a high rate (21.8%), and convert on over 35% of three-point shots.

Expect to see Iowa State lean on their stellar defense to come away with the victory. Lipscomb plays at a snail’s pace, plus make the most of every trip down the floor with an stellar turnover percentage of just 14.4 and by shooting 55.9% from the field, good for 23rd in the nation. While their overmatched here, the Bisons can cause the Cyclones real problems on both ends of the floor. Lipscomb has the talent to keep this round of 64 matchup close.

Pick: Lipscomb +14.5 (-110) at DraftKings

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Lipscomb vs Iowa State Player Props

Lipscomb forward Jacob Ognacevic has exceeded 26 points and rebounds in 12 of his last 13 games while averaging 31.15 per contest. The Wisconsin native is shooting 59% from the field during that stretch while grabbing 8.5 boards a night. While the Cyclones defense will provide a stiff test, expect to see Ognacevic be the catalyst of everything the Bisons do on offense. After all, the big man has put up over 20 points per game this season. Bet on Ognacevic to go over 26 points and rebounds versus Iowa State.

Without Tamin Lipsey and Keshon Gilbert, Curtis Jones has taken up the mantle for the Iowa State Cyclones. The senior averaged 17.1 points per game on the year and exploded for 31 points last time out against BYU. Expect Jones to lead the Cyclones offensively and knock down at least 18 points to power Iowa State to victory.

Lipscomb guard Will Pruitt has surpassed 15 points and assists in eight of his last 10 games, while averaging 18.3 points and assists per night. Pruitt is a massive part of the Bisons offensive attack, shooting 42% from the three-point line in that stretch. Look for Pruitt to continue his hot streak in this Lipscomb vs Iowa State contest.

Lipscomb vs Iowa State Odds

Iowa State are huge -1450 moneyline favorites as they take on No. 14 Lipscomb who are +850 underdogs. The Cyclones are 14.5-point favorites in Friday’s college basketball odds.

Odds as of March 20th, at DraftKings Sportsbook. Check out SBD’s list of the best March Madness betting apps to wager on the 2025 tournament.