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Opening College Football Week 4 Odds, Including Auburn vs Oklahoma, Illinois vs Indiana Point Spreads

Sascha Paruk

By Sascha Paruk in College Football

Published:


Miami Hurricanes quarterback Carson Beck scoring a rushing TD against USF
Sep 13, 2025; Miami Gardens, Florida, USA; Miami Hurricanes quarterback Carson Beck (11) carries the football for a touchdown against South Florida Bulls fullback D.J. Harris (11) during the second quarter at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images
  • The NCAAF Week 4 odds have been posted
  • Four ranked-on-ranked matchups highlight the college football Week 4 betting lines
  • See the opening college football Week 4 odds, including point spread, moneyline, and total for every game

Week 3 is in the books and the NCAAF Week 4 odds have started to trickle out at online sportsbooks. Week 4 is highlighted by four ranked-on-ranked games: #24 Auburn vs #13 Oklahoma, #9 Illinois vs #22 Indiana, #11 South Carolina vs #25 Missouri, and #21 Texas Tech vs #20 Utah. Three of those four games are battles of unbeatens.

The table below sets out the opening NCAAF Week 4 odds (spread, moneyline, and total) for every game on the board. More games and lines will be added as odds are posted.

College Football Week 4 Odds

TeamSpreadMLTotal
Rice-5.5 (-110)-175O 42.5 (-110)
Charlotte+5.5 (-110)+145U 42.5 (-110)
TeamSpreadMLTotal
Tulsa+14 (-110)+380O 56.5 (-110)
OK State-14 (-110)-500U 56.5 (-110)
TeamSpreadMLTotal
Iowa-2.5 (-110)-120O 45.5 (-110)
Rutgers+2.5 (-110)+100U 45.5 (-110)
TeamSpreadMLTotal
Texas Tech+4 (-110)+145O 55.5 (-110)
Utah-4 (-110)-175U 55.5 (-110)
TeamSpreadMLTotal
SMU+6 (-110)+195O 63.5 (-110)
TCU-6 (-110)-238U 63.5 (-110)
TeamSpreadMLTotal
Maryland+7 (-110)+205O 43.5 (-110)
Wisconsin-7 (-110)-250U 43.5 (-110)
TeamSpreadMLTotal
Syracuse+17.5 (-110)+500O 55.5 (-110)
Clemson-17.5 (-110)-700U 55.5 (-110)
TeamSpreadMLTotal
Arkansas-5.5 (-110)-238O 62.5 (-110)
Memphis+5.5 (-110)+195U 62.5 (-110)
TeamSpreadMLTotal
Bowling Green+26.5 (-110)+1600O 51.5 (-110)
Louisville-26.5 (-110)-4000U 51.5 (-110)
TeamSpreadMLTotal
UNLV-4.5 (-110)-148O 48.5 (-110)
Miami OH+4.5 (-110)+124U 48.5 (-110)
TeamSpreadMLTotal
UAB+41.5 (-110)OFFO 67.5 (-110)
Tennessee-41.5 (-110)OFFU 67.5 (-110)
TeamSpreadMLTotal
Oregon State+35.5 (-110)OFFO 56.5 (-110)
Oregon-35.5 (-110)OFFU 56.5 (-110)
TeamSpreadMLTotal
Ball State+19.5 (-110)+800O 52.5 (-110)
UConn-19.5 (-110)-1350U 52.5 (-110)
TeamSpreadMLTotal
James Madison-12.5 (-110)-380O 48.5 (-110)
Liberty+12.5 (-110)+300U 48.5 (-110)
TeamSpreadMLTotal
Troy+7 (-110)+200O 42.5 (-110)
Buffalo-7 (-110)-245U 42.5 (-110)
TeamSpreadMLTotal
Toledo-12.5 (-110)-500O 51.5 (-110)
W. Michigan+12.5 (-110)+380U 51.5 (-110)
TeamSpreadMLTotal
Michigan-2.5 (-110)-142O 44.5 (-110)
Nebraska+2.5 (-110)+120U 44.5 (-110)
TeamSpreadMLTotal
Purdue+27.5 (-110)+2200O 52.5 (-110)
Notre Dame-27.5 (-110)-8000U 52.5 (-110)
TeamSpreadMLTotal
Auburn+4.5 (-110)+160O 49.5 (-110)
Oklahoma-4.5 (-110)-192U 49.5 (-110)
TeamSpreadMLTotal
Kent State+45.5 (-110)OFFO 56.5 (-110)
Florida State-45.5 (-110)OFFU 56.5 (-110)
TeamSpreadMLTotal
Tulane+13.5 (-110)+320O 60.5 (-110)
Ole Miss-13.5 (-110)-410U 60.5 (-110)
TeamSpreadMLTotal
UNC+5.5 (-110)+185O 49.5 (-110)
UCF-5.5 (-110)-225U 49.5 (-110)
TeamSpreadMLTotal
NC State+2.5 (-110)+110O 59.5 (-110)
Duke-2.5 (-110)-130U 59.5 (-110)
TeamSpreadMLTotal
N. Illinois+21 (-110)+1200O 49.5 (-110)
Miss. State-21 (-110)-2400U 49.5 (-110)
TeamSpreadMLTotal
Temple+24.5 (-110)+1300O 53.5 (-110)
Ga. Tech-24.5 (-110)-2800U 53.5 (-110)
TeamSpreadMLTotal
Delaware+3 (-110)+140O 54.5 (-110)
FIU-3 (-110)-166U 54.5 (-110)
TeamSpreadMLTotal
Arkansas St.-6.5 (-110)-250O 54.5 (-110)
Kennesaw St.+6.5 (-110)+205U 54.5 (-110)
TeamSpreadMLTotal
South Carolina+11.5 (-110)+350O 46.5 (-110)
Missouri-11.5 (-110)-455U 46.5 (-110)
TeamSpreadMLTotal
West Virginia+11.5 (-110)+340O 54.5 (-110)
Kansas-11.5 (-110)-440U 54.5 (-110)
TeamSpreadMLTotal
Marshall-4.5 (-110)-135O 47.5 (-110)
MTSU+4.5 (-110)+114U 47.5 (-110)
TeamSpreadMLTotal
Nevada+12.5 (-110)+295O 54.5 (-110)
W. Kentucky-12.5 (-110)-375U 54.5 (-110)
TeamSpreadMLTotal
Boise State-9.5 (-110)-310O 51.5 (-110)
Air Force+9.5 (-110)+250U 51.5 (-110)
TeamSpreadMLTotal
CCU+14 (-110)+455O 51.5 (-110)
S. Alabama-14 (-110)-625U 51.5 (-110)
TeamSpreadMLTotal
Illinois+3.5 (-110)+145O 52.5 (-110)
Indiana-3.5 (-110)-175U 52.5 (-110)
TeamSpreadMLTotal
Florida+8.5 (-110)+260O 52.5 (-110)
Miami-8.5 (-110)-325U 52.5 (-110)
TeamSpreadMLTotal
Arizona State+2.5 (-110)+110O 59.5 (-110)
Baylor-2.5 (-110)-130U 59.5 (-110)
TeamSpreadMLTotal
Washington-20.5 (-110)-1450O 53.5 (-110)
Washington St.+20.5 (-110)+850U 53.5 (-110)
TeamSpreadMLTotal
Georgia State+25.5 (-110)+1300O 53.5 (-110)
Vanderbilt-25.5 (-110)-2800U 53.5 (-110)
TeamSpreadMLTotal
Stanford+14.5 (-110)+525O 48.5 (-110)
Virginia-14.5 (-110)-750U 48.5 (-110)
TeamSpreadMLTotal
BYU-8.5 (-110)OFFO 49.5 (-110)
ECU+8.5 (-110)OFFU 49.5 (-110)
TeamSpreadMLTotal
Southern Miss.+1.5 (-110)-102O 51.5 (-110)
La. Tech-1.5 (-110)-118U 51.5 (-110)
TeamSpreadMLTotal
Sam Houston+40.5 (-110)OFFO 51.5 (-110)
Texas-40.5 (-110)OFFU 51.5 (-110)
TeamSpreadMLTotal
ULM+4 (-110)+140O 47.5 (-110)
UTEP-4 (-110)-166U 47.5 (-110)
TeamSpreadMLTotal
UTSA-4 (-110)-166O 58.5 (-110)
Colorado St.+4 (-110)+140U 58.5 (-110)
TeamSpreadMLTotal
Wyoming+14 (-110)+410O 43.5 (-110)
Colorado-14 (-110)-550U 43.5 (-110)
TeamSpreadMLTotal
California-11.5 (-110)-500O 48.5 (-110)
San Diego St.+11.5 (-110)+380U 48.5 (-110)
TeamSpreadMLTotal
Michigan St.+14.5 (-110)+490O 55.5 (-110)
USC-14.5 (-110)-675U 55.5 (-110)
TeamSpreadMLTotal
Fresno State-3.5 (-110)-155O 47.5 (-110)
Hawai’i+3.5 (-110)+130U 47.5 (-110)

There are some massive spreads on the board in the Week 4 college football odds, none higher than the 45.5-point line in Kent State vs Florida State.

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Odds as of 1:48 pm ET at DraftKings. Use SBD’s guide to find the best betting sites for college football.

Week 4 will start with Rice vs Charlotte on Thursday, Sep. 18 (7:30 pm ET) before a pair of games on Friday, Sep. 19: Tulsa vs OK State (7:30 pm ET) and Iowa vs Rutgers (8:00 pm ET). No ranked teams are in action until Saturday, Sep. 20.

Bookmark SBD’s college football public betting percentages to see how the lines move over the course of the week and where the money is going in each matchup.

Florida vs Miami Odds Heavily Favor Hurricanes

The in-state battle between the SEC’s Florida Gators (1-2) and ACC’s Miami Hurricanes (3-0) has lost some of its preseason lustre after the Gators lost for the second straight week on Saturday, falling 20-10 at LSU, one week after getting upset 18-16 at home by South Florida as 18.5-point favorites.

The #5 Hurricanes just hammered that same USF team 49-12, easily covering as 17.5-point home chalk. Miami also owns a win over then-#6 Notre Dame (27-24) in Week 1 and is the top-ranked team from the ACC early in the season.

Miami has opened as an 8.5-point home favorite at Hard Rock Stadium in Miami Gardens. Florida vs Miami kicks off at 7:30 pm ET on Saturday, Sep. 20.

Auburn vs Oklahoma Spread Favors Sooners at Home

Arguably the game of the week sees #24 Auburn (3-0, 1-2 ATS) visiting #13 Oklahoma (3-0, 2-1 ATS) in Norman at 3:30 pm ET on Saturday in the first SEC game for both teams this season. OU has opened as a 4.5-point home favorite.

Both teams have faced on power-conference opponent so far. Oklahoma beat then-#15 Michigan (24-13) at home in Week 2, covering as four-point chalk. The Sooner also own lopsided wins over Illinois State (35-3 as 40.5-point favorites) and Temple (42-3 as 24-point favorites).

Auburn started the season with a 38-24 rout of Baylor as one-point road favorites. In Week 2, they beat Ball State 42-3 as 42.5-point home chalk. Last Saturday, they beat South Alabama 31-15 at home as 26.5-point favorites.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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