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College Football Picks Today: Best Bets for Week 6 (Oct. 4)

John Hyslop

By John Hyslop in College Football

Published:


Sep 20, 2025; Miami Gardens, Florida, USA; Miami Hurricanes quarterback Carson Beck (11) and his teammates walk toward the line of scrimmage against the Florida Gators during the fourth quarter at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images
  • We’ve got another action-packed College Football slate on Saturday, October 4
  • I’m thinking we go in on the Vanderbilt/Alabama tilt, then finish up with Miami/Florida State
  • See below for the way I’m playing these absolute smash situations

I don’t know what to say at this point. We’ve literally turned our sports betting accounts into personal, hand-held ATMs. I’ve never seen anything like it. Still, I know what to do. The smartest way to play this situation is to not change anything. We’re just going to keep riding what works. We need to make sure we’re sitting in the same spots, eating the same game-day snacks, and drinking the same beverages we normally drink during our bets. It just has to be like that.

But the most important thing we can do at this point to keep this run going is keep playing the boosts. Both DraftKings and FanDuel have boosts this Saturday, so we need to use both. By using the boosts, we can make almost anything plus money and when that happens, all we have to do is go 1-1 and we’ll stuff cash in our pockets. Feels easy.

Saturday College Football Picks (Week 6)

TeamSpreadMoneylineTotal
Vanderbilt+10.5 (-108)+330O 55.5 (-110)
Alabama-10.5 (-112)-425U 55.5 (-110)
TeamSpreadMoneylineTotal
Miami -4.5 (-106)-180O 53.5 (-115)
Florida State +4.5 (-114)+152U 53.5 (-105)

All odds as of Oct. 3 from FanDuel & DraftKings. Claim the FanDuel promo code to sign up and tail our picks.

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  • FANATICS SPORTSBOOK

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  • DRAFTKINGS SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS IF YOUR BET WINS

  • FANDUEL SPORTSBOOK

    BET $5 & GET $300 IF YOUR BET WINS

  • CAESARS SPORTSBOOK

    USE CODE SBD20X & BET $1 TO DOUBLE THE WINNINGS ON YOUR FIRST 20 WAGERS!

  • ESPN BET SPORTSBOOK

    USE CODE DIME TO UNLOCK BET $10, GET $100 BONUS & ESPN+

  • DRAFTKINGS SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS).

  • Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO, IL, KS, KY, MD, MI, NC, NJ, OH, PA, TN, VA, VT, WV, WY); (800) 327-5050 or gamblinghelplinema.org (MA); (877) 8-HOPENY (NY); 1-800-NEXT-STEP (AZ); (888) 789-7777 (CT); 1-800-BETS-OFF (IA); 1-800-9-WITH-IT (IN); mdgamblinghelp.org (MD); morethanagame.nc.gov (NC); 1800gambler.net (WV)

Week 6 College Football Pick #1 – Vanderbilt and Alabama Might Score 1000 Points

We’ll start our day at 3:30 pm ET with the Vanderbilt/Alabama matchup. It wasn’t long ago that this game was a laugher, but that is no longer the case. The kids at Vanderbilt are playing with a ton of pride, and it’s noticeable. They even have Theo Von on the sidelines sometimes.

This team is fun, but if we’re being honest with ourselves, it’s hard to not be fun when you have the sweet fits Vanderbilt will be rocking this week.

Sweet uniforms are nice and all, but it’s the kids in the uniforms that make the team, and Vanderbilt is led by a good one in quarterback Diego Pavia. We already saw this kid beat Alabama last season, so we know he’s legit. The thing is, he’s back this season slinging the rock better than he ever has.

So far this season, we’ve seen Pavia lead Vandy to 40+ points in four of five games. The kid doesn’t know how to not score, and that will be fine for us over backers. The haters are going to say he hasn’t dropped a 40-burger in every game, but the one game he didn’t, he dropped 31 on the South Carolina Gamecocks. The kid is nasty.

In all honesty, we’ll take a 30-burger out of Pavia because I’m 100% certain Alabama is going to hang points themselves. We’re talking at least 30 here. As good as Vandy’s offense has been, their defense has been just as bad. We just watched them give up 35 last week to Utah State. No disrespect to Utah State, but they’re not Bama. And since Vandy beat Bama last season, we should get a focused and ready Crimson Tide. This game is going way over 55.5 points. Feels easy.

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Week 6 College Football Pick #2 – The Scoreboard Operator Will Be Busy In Tallahassee

The only thing better than one over is back-to-back overs. There’s just something about watching a 3:30 pm over cash and then flipping the channel to another over at 7:30. That’s what we call “living the dream” on the streets. It just doesn’t get better.

On top of that, we have another sweet uniform game, which is literally the icing on the cake.

As we learned with Vanderbilt, we need good players in these sweet uniforms, and we have them in Miami. The haters are going to say that they didn’t score much last week, but that wasn’t their fault. For starters, they still hung 26 points, but Florida didn’t give them much of a challenge offensively. Miami knew they wouldn’t need many points to win that game, so why show the playbook?

That won’t be the case in Tallahassee on Saturday night. The Florida State Seminoles are assassins on offense. We’ve seen a 60-burger and a 70-burger out of these kids so far this season. The haters are going to say those games were against BS schools, but what about the time they dropped 31 on Alabama? This game should go back and forth, and when it’s over, there will be more than 54 points on the board. Feels easy.

  • BETMGM SPORTSBOOK

    USE CODE SBD1500 & GET $1,500 BACK IN BONUS BETS

  • BET365 SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS WITH CODE DIME365

  • FANATICS SPORTSBOOK

    BET $10, GET $100 IN FANCASH + GAMEDAY GUARANTEE

  • DRAFTKINGS SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS IF YOUR BET WINS

  • FANDUEL SPORTSBOOK

    BET $5 & GET $300 IF YOUR BET WINS

  • CAESARS SPORTSBOOK

    USE CODE SBD20X & BET $1 TO DOUBLE THE WINNINGS ON YOUR FIRST 20 WAGERS!

  • ESPN BET SPORTSBOOK

    USE CODE DIME TO UNLOCK BET $10, GET $100 BONUS & ESPN+

  • DRAFTKINGS SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD). 21+ and present in most states. (18+ DC/KY/NH/WY). Void in ONT/OR/NH. Eligibility restrictions apply. On behalf of Boot Hill Casino & Resort (KS).

  • Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO, IL, KS, KY, MD, MI, NC, NJ, OH, PA, TN, VA, VT, WV, WY); (800) 327-5050 or gamblinghelplinema.org (MA); (877) 8-HOPENY (NY); 1-800-NEXT-STEP (AZ); (888) 789-7777 (CT); 1-800-BETS-OFF (IA); 1-800-9-WITH-IT (IN); mdgamblinghelp.org (MD); morethanagame.nc.gov (NC); 1800gambler.net (WV)

John Hyslop

John has spent the past 20+ years betting sports on a daily basis and is considered by many to be a walking sports betting encyclopedia. From obscure player props to sides and totals, if there is an angle, John will find it.

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