Clemson vs Louisville Prediction & Same-Game Parlay to Bet for Friday Night

• #20 Louisville is a 2.5-point favorite over Clemson in ACC play on Friday Night
• The Cardinals are 1-6 ATS in their last seven home games
• See below for my Clemson vs Louisville Prediction and Same-Game Parlay to Bet for Friday Night

ACC rivals clash tonight as Clemson (4-5, 3-4 ACC) visits #20 Louisville (7-2, 4-2 ACC). The Cardinals opened as 3.5-point favorites in the college football odds, but money has come pouring in on the Tigers late in the week.

Kickoff is scheduled for 7:30pm ET from L&N Federal Credit Union Stadium, in Louisville, KY, with ESPN providing the broadcast coverage.

Here is my Clemson vs Louisville prediction and same-game parlay picks.

Clemson vs Louisville Prediction

I’m buying the steam on Clemson. The Tigers have dropped to +2.5 at most commercial books as of Friday morning, with some even lowering the spread to +1.5.

Clemson played one of its best games of the season last week, beating a very good Florida State team 24-10. The Tigers held the Seminoles potent offense in check by forcing two turnovers and generating six sacks, which was the kind of production we expected from their defense in the preseason. That unit was one of the reasons Clemson was a CFP odds contender, but inconsistency has plagued them throughout the year.

The same can be said for their offense. Cade Klubnik has been a colossal disappointment this season, after earning a ton of preseason Heisman Trophy odds hype. Klubnik was efficient versus Florida State however, completing 74% of his throws, for 221 yards and a TD.

Klubnik will need a strong game for the Tigers to cover tonight, as Clemson’s run game is non-existent. They rank 91st in yards per carry, and 100th in rushing yards per game.

On paper, the matchup with the Cardinals defense looks imposing, but a lot of their success has come against bad teams. Cal’s Jaron Keawe Sagapolutele lit them up last week in an upset win, throwing for 323 yards and two scores. No offense to Sagapolutele, but no Draft expert has ever had him atop of their Mocks, while Klubnik was the number one pick on on his fair share for a while.

As for the Louisville offense, expect a run heavy approach. That’s because QB Miller Moss is a turnover machine, and averages just 6.9 yards per attempt. The problem is, that plays right into Clemson’s defensive strength.

Clemson Defense Stats

The Cardinals defense ranks 27th in yards per carry, and 17th in rushing yards allowed per game. It also hurts Louisville that star RB Isaac Brown is out, although there isn’t a huge drop off to back-up Keyjuan Brown.

The Tigers have the ingredients to slow down Louisville’s offense, and should get superior QB play. That’s all I’m looking for in an underdog pick, and I think you could make the argument that Clemson wins this game outright. From a trends perspective, Louisville has not been a team to back at home. They’re 1-6 ATS in their last seven games inside their own stadium.

Clemson vs Louisville Same-Game Parlay

Moving over to my Clemson vs Louisville same-game parlay picks, where I’ve put together a three-leg SGP with a +370 payout if it hits.

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I’m starting with Clemson +2.5, and adding 2+ TD passes for Klubnik. It’s a mark he’s reached in four of his last seven starts, and I expect him to carve up the Cardinals just like Sagapolutele did last week.

I’ll round out my SGP with 60+ rushing yards for Brown despite the tough matchup. Given Moss’ inconsistent play, Louisville is not going to abandon the run even against a strong defense. Brown has seen double-digit rush attempts in three straight games, and has little competition for carries behind him. He enters the game averaging 6.9 yards per attempt, and has at least one explosive run in three straight outings.