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Opening NFL Week 12 Odds – Spread, Moneyline, Total for All 14 Games

Sascha Paruk

By Sascha Paruk in NFL News

Published:


Dallas Cowboys wide receiver CeeDee Lamb tries to make a leaping catch
Sep 4, 2025; Philadelphia, Pennsylvania, USA; Dallas Cowboys wide receiver CeeDee Lamb (88) is unable to make a reception defended by Philadelphia Eagles cornerback Cooper DeJean (33) during the fourth quarter of the game at Lincoln Financial Field. Mandatory Credit: Eric Hartline-Imagn Images
  • The NFL Week 12 odds have been posted at online sportsbooks
  • Four teams are on bye (Broncos, Chargers, Commanders, Dolphins), leaving 14 games on the Week 12 slate
  • See the opening NFL Week 12 odds for all games, including the spread, moneyline, and total

The NFL Week 12 odds have been posted, headlined by a heavyweight NFC clash between the Tampa Bay Buccaneers and Los Angeles Rams on SNF.

The table below lists the opening NFL Week 12 odds for all 14 games on the slate, roughly in chronological order.

NFL Week 12 Odds

TeamSpreadMLO/U
BUF Bills-4.5 (-110)-22043.5 (-110)
HOU Texans+ 4.5 (-110)+18443.5 (-110)
TeamSpreadMLO/U
MIN Vikings+6.5 (-115)+23543.5 (-110)
GB Packers-6.5 (-105)-29043.5 (-110)
TeamSpreadMLO/U
IND Colts+3.5 (-102)+18050.5 (-110)
KC Chiefs-3.5 (-120)-21550.5 (-110)
TeamSpreadMLO/U
NE Patriots-5.5 (-118)-29050.5 (-110)
CIN Bengals+5.5 (-110)+23550.5 (-110)
TeamSpreadMLO/U
PIT Steelers+2.5 (-110)+11444.5 (-110)
CHI Bears-2.5 (-110)-13444.5 (-110)
TeamSpreadMLO/U
NY Jets +13.5 (-110)+70044.5 (-110)
BAL Ravens-13.5 (-110)-110044.5 (-110)
TeamSpreadMLO/U
NY Giants+10.5 (-110)+57048.5 (-110)
DET Lions-10.5 (-110)-82048.5 (-110)
TeamSpreadMLO/U
SEA Seahawks-12.5 (-110)-90042.5 (-110)
TEN Titans+12.5 (-110)+61042.5 (-110)
TeamSpreadMLO/U
JAX Jaguars-1.5 (-105)-12045.5 (-110)
ARI Cardinals+1.5 (-115)+10245.5 (-110)
TeamSpreadMLO/U
CLE Browns+3.0 (-105)+13837.5 (-110)
LV Raiders-3.0 (-115)-16437.5 (-110)
TeamSpreadMLO/U
PHI Eagles-3.5 (-120)-20551.5 (-112)
DAL Cowboys+3.5 (-102)+17251.5 (-108)
TeamSpreadMLO/U
ATL Falcons-2.5 (-110)-13440.5 (-105)
NO Saints+2.5 (-110)+11440.5 (-115)
TeamSpreadMLO/U
TB Buccaneers+6.5 (-105)+26049.5 (-105)
LA Rams-6.5 (-115)-32049.5 (-115)
TeamSpreadMLO/U
CAR Panthers+7.0 (-115)+29046.5 (-120)
SF 49ers-7.0 (-105)-36046.5 (-102)

A couple massive spreads are on the board in Week 12: the Baltimore Ravens (4-5) are favored by 13.5 at home against the New York Jets (2-8), while the Detroit Lions (6-3) are favored by 10.5 at home against the New York Giants (2-9). The highest total on the board is 51.5 O/U in Eagles vs Cowboys, while the lowest is just 37.5 in Browns vs Raiders.

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Odds as of 6:29 pm ET, November 16th, at FanDuel, DraftKings, and Fanatics. See the latest news from Fanatics Sportsbook Missouri ahead of pre-registration on Monday.

Opening Colts vs Chiefs Odds

Week 12 features a heavyweight AFC tilt between the Indianapolis Colts (8-2) and the desperate Kansas City Chiefs (5-4), who are trying to claw their way back into the NFL playoff bracket in the AFC.

The Chiefs have opened as modest 3.5-point favorites against an Indianapolis team coming off a bye. The Colts are 6-0 at home this season but just 2-2 on the road. Kansas City is 4-1 at home and riding a four-game win streak at Arrowhead.

Opening Buccaneers vs Rams Odds

One spread that’s a little eye-popping at first glance is the Los Angeles Rams (7-2) laying 6.5 points at home against the very game Tampa Bay Buccaneers (6-4).

The Rams have been rewarding bettors all year, though. At the time of publication, they were tied with the Seahawks for the best ATS record in the NFL (7-2 ATS) and were up 21-12 on those same Seahawks late in the fourth quarter of a crucial NFC West clash, on pace to cover as field-goal favorites.

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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