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A.I. NFL Picks for Week 13 – ATS Picks & O/U Predictions for Thanksgiving

Sascha Paruk

By Sascha Paruk in NFL News

Published:


Detroit Lions running back Jahmyr Gibbs runs with the ball as Green Bay Packers safety Javon Bullard tries to make the tackle
Green Bay Packers safety Javon Bullard (20) pursues Detroit Lions running back Jahmyr Gibbs (0) on Sunday, September 7, 2025, at Lambeau Field in Green Bay, Wis. The Packers won the game, 27-13. Tork Mason/USA TODAY NETWORK-Wisconsin
  • The NFL is back to a full 16-game schedule in Week 13
  • I have asked our A.I. to find its favorite NFL ATS picks and O/U bets to target in Week 13
  • See the NFL ATS picks and O/U predictions for every Week 13 from our A.I.

The NFL is back to a full 16-game schedule for the week of Thanksgiving, starting with the usual trio of Thursday games plus the news Black Friday tradition.

I have asked our internal A.I to analyze the best ATS and O/U bet for each game. The table below sets out the NFL ATS picks and O/U predictions for Week 13.

NFL ATS Picks & O/U Predictions for Week 13

GameATS PickO/U Pick
Green Bay Packers @ Detroit LionsLions -2.5Over 48.5
Kansas City Chiefs @ Dallas CowboysChiefs -3.0Under 52.5
Cincinnati Bengals @ Baltimore RavensRavens -6.5Under 52.5
Chicago Bears @ Philadelphia EaglesBears +7Over 44.5
Jacksonville Jaguars @ Tennessee TitansTitans +7.0Over 41.5
Atlanta Falcons @ New York JetsJets +2.5Over 39.5
Los Angeles Rams @ Carolina PanthersPanthers +10.5Over 45.5
New Orleans Saints @ Miami DolphinsSaints +6.0Over 41.5
Arizona Cardinals @ Tampa Bay BuccaneersCardinals +2.5Over 44.0
San Francisco 49ers @ Cleveland Browns49ers -6.0Over 39.5
Houston Texans @ Indianapolis ColtsColts -3.5Over 44.0
Minnesota Vikings @ Seattle SeahawksSeahawks -9.5Under 42.5
Buffalo Bills @ Pittsburgh SteelersBills -3.5Under 47.5
Las Vegas Raiders @ Los Angeles ChargersRaiders +10.0Over 41.0
Denver Broncos @ Washington CommandersBroncos -6.5Under 43.5
New York Giants @ New England PatriotsGiants +7.5Over 46.5

The A.I. is coming off its first week of the season where it was over .500 on both its ATS picks (7-5-1) and its O/U picks (8-5). It’s still abysmal on both fronts over the course of the season, as a whole, though:

  • A.I. ATS record in NFL regular season: 69-79-1
  • A.I. O/U record in NFL regular season: 66-83

Use SBD’s NFL public betting splits page to see where the A.I. and sharps align on their NFL ATS picks for Week 13.

A.I. NFL Picks for Thanksgiving

GB vs DET: Lions -2.5 & Over 48.5

KC vs DAL: Chiefs -3.0 & Under 52.5

CIN vs BAL: Ravens -7.5 & Under 52.5

The A.I. has targeted all three favorites in the trio of Thanksgiving games on Nov. 27: Lions -3 (vs Packers), Chiefs -3.5 (at Cowboys), and Ravens -7.5 (vs Bengals). Overall, the A.I. is evenly split between underdogs and favorites ATS in Week 13, taking eight of each.

The same can’t be said for its over/under bets. It’s had a lean towards unders for most of the season, but in Week 13, the A.I. has made 11 over bets and just five under bets. It does like two Thanksgiving unders, though: Chiefs vs Cowboys under 52.5 (which is the highest total on the board in Week 13) and Bengals vs Ravens under 51.5 (which is the second-highest O/U of the week).

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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