NFL Week 3 Odds – Opening Spread, Total, Moneyline for All 16 Games
By Sascha Paruk in NFL News
Published:
As the NFL heads into Week 3 of the 2026 regular season, sportsbooks have released initial betting lines for the upcoming slate. Opening numbers from DraftKings are now out for 15 of 16 games.
Below is the complete board of opening Week 3 NFL odds.
NFL Week 3 Odds
Odds marked with * are from FanDuel. All other NFL point spreads are from DraftKings.
Opening Eagles vs Bears Odds
The Philadelphia Eagles head to Soldier Field for a Monday Night Football clash as 4.5-point road favorites (-115 juice) against the Chicago Bears (+4.5 at -105) in the opening MNF odds. Philadelphia’s -218 moneyline gives them a 68.6% implied win probability, while Chicago enters as a +180 home underdog.
The spread sitting beyond the critical field-goal threshold heavily factors in Chicago’s quarterback situation after Caleb Williams was carted off the field during their Week 2 loss to Minnesota, leaving Tyson Bagent in line to start under center. With Bagent steering the offense against a fierce Philadelphia front, the game total opens at a suppressed 43.5 (O -110/U -110), pointing toward a run-heavy, defensive battle under the lights.
Opening Falcons vs Packers Odds
Week 3 action kicks off at Lambeau Field on Thursday night, where the Green Bay Packers are 7-point home favorites over the Atlanta Falcons in the opening TNF odds. DraftKings has installed Green Bay at -325 on the moneyline (76.5% implied win probability), with Atlanta returning at +260.
The spread sitting squarely on the critical key number of 7 reflects solid bookmaker confidence in Green Bay’s home-field advantage. The total is listed at 44.5 points with standard -110 juice on both sides, suggesting a moderate scoring pace under the primetime lights in Green Bay.
Opening Jets vs Lions Odds
The Detroit Lions open as substantial home favorites at Ford Field, laying a full touchdown (-7 at -120 juice) against the visiting New York Jets (+7 at even money, +100). Detroit’s -345 moneyline represents the heaviest favorite price among all currently posted Week 3 games on DraftKings, carrying an implied win probability of 77.5%.
Opening Panthers vs Browns Odds
In an intriguing inter-conference clash, the Carolina Panthers open as 2.5-point road favorites in Cleveland. With Carolina juiced to -118 at -2.5 and priced at -148 on the moneyline, oddsmakers anticipate early sharp interest backing the road squad.
This contest holds the lowest total on the board at 41.5 points, with the Under shaded to -118, pointing toward a defensive trench battle where points will come at a premium.
Opening Vikings vs Buccaneers Odds
The Minnesota Vikings head to Raymond James Stadium as short road favorites, opening at -2.5 (-105) against the Tampa Bay Buccaneers (+2.5 at -115). Minnesota holds a -130 moneyline edge (56.5% implied probability), while Tampa Bay sits at +110 as a home underdog.
The total is set at 44.5 points, balancing Minnesota’s balanced offensive attack against a physical Tampa Bay defensive front in what projects to be a tight one-score battle.
Opening Cardinals vs 49ers Odds
In an NFC West divisional clash, the San Francisco 49ers open as heavy 8.5-point home favorites (-110) over the Arizona Cardinals (+8.5 at -110). San Francisco’s -455 moneyline (82.0% implied probability) marks them as one of the most prohibitive home favorites on the board, while Arizona returns at +350. The game total is established at a robust 47.5 (O -110/U -110), indicating expectations of an up-tempo matchup where San Francisco’s multifaceted ground and aerial attack drives the scoreboard.
Opening Chargers vs Bills Odds
Two marquee AFC contenders clash at Highmark Stadium, where the Buffalo Bills open as 6.5-point home favorites (-110) against the visiting Los Angeles Chargers (+6.5 at -110). Buffalo sits at -270 on the moneyline (73.0% implied probability), with the Chargers positioned at +220. This matchup commands the highest total among all posted Week 3 games at 50.5 (O -110/U -110), pointing toward a fast-paced, high-scoring duel between two of the conference’s elite offenses.
Opening Seahawks vs Commanders Odds
The Seattle Seahawks hit the road as 4.5-point favorites (-110) against the Washington Commanders (+4.5 at -110) in an intriguing inter-division battle. Seattle’s -205 moneyline (67.2% implied win rate) establishes them as solid road favorites, with Washington returning at +170. Tied for the lowest total on the board at 41.5 (O -110/U -110) alongside Panthers-Browns, oddsmakers project a defensive-minded, field-position struggle where third-down efficiency will dictate the outcome.
Opening Ravens vs Cowboys Odds
In one of the most anticipated non-conference clashes of the week, the Baltimore Ravens visit Arlington as 3-point road favorites (-104) against the Dallas Cowboys (+3 at -118). Baltimore holds a -152 moneyline edge (60.3% implied win rate), with Dallas returning at +128. Notably, this matchup commands the highest game total on the entire Week 3 slate at 51.5 (O -118/U -104). Oddsmakers anticipate a fast-paced shootout inside AT&T Stadium, with both high-powered passing attacks poised to generate explosive plays.
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Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
