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Opening NFL Week 15 Odds – Spread, Total, Moneyline for All Games

Sascha Paruk

By Sascha Paruk in NFL News

Published:


Los Angeles Chargers wide receiver Quentin Johnston running with the ball against the Kansas City Chiefs
[US, Mexico & Canada customers only] Sep 5, 2025; Sao Paulo, BRAZIL; Los Angeles Chargers wide receiver Quentin Johnston (1) runs against Kansas City Chiefs safety Jaden Hicks (21) before scoring a touchdown in the second half during a NFL game at Corinthians Arena. Mandatory Credit: Amanda Perobelli/Reuters via Imagn Images
  • Online sportsbooks have posted the opening NFL Week 15 odds
  • Huge playoff implications abound in Ravens vs Bengals, Chargers vs Chiefs, and more
  • See the opening NFL Week 15 odds (spread, moneyline, and total) for all 16 games

Just four full weeks remain in the regular season and the playoff races in both conferences have reached a fever pitch. The NFL Week 15 odds have already been posted at online sportsbooks. With no byes remaining, bettors will have a full 16-slate to feast on from here on out.

The table below lists the opening NFL Week 15 odds for each game, roughly listed in chronological order.

NFL Week 15 Odds

TeamSpreadMoneylineTotal
ATL Falcons+5.5 (-110)+195O 44.5 (-105)
TB Buccaneers-5.5 (-110)-238U 44.5 (-115)
TeamSpreadMoneylineTotal
CLE Browns+7.0 (-105)+340O 39.5 (-110)
CHI Bears-7.0 (-115)-440U 39.5 (-110)
TeamSpreadMoneylineTotal
BAL Ravens-3.0 (-100)-162O 51.5 (-110)
CIN Bengals+3.0 (-120)+136U 51.5 (-110)
TeamSpreadMoneylineTotal
LA Chargers+4.5 (-110)+170O 44.5 (-110)
KC Chiefs-4.5 (-110)-205U 44.5 (-110)
TeamSpreadMoneylineTotal
BUF Bills+1.5 (-118)-102O 47.5 (-110)
NE Patriots-1.5 (-102)-118U 47.5 (-110)
TeamSpreadMoneylineTotal
WSH Commanders-2.5 (-110)-135O 47.5 (-110)
NY Giants+2.5 (-110)+114U 47.5 (-110)
TeamSpreadMoneylineTotal
LV Raiders+12.5 (-110)+625O 40.0 (-110)
PHI Eagles-12.5 (-110)-950U 40.0 (-110)
TeamSpreadMoneylineTotal
NY Jets+8.5 (-105)+350O 42.5 (-118)
JAX Jaguars-8.5 (-115)-455U 42.5 (-102)
TeamSpreadMoneylineTotal
ARI Cardinals+7.0 (-115)+260O 42.5 (-110)
HOU Texans-7.0 (-105)-320U 42.5 (-110)
TeamSpreadMoneylineTotal
GB Packers-2.5 (-110)-130O 42.5 (-110)
DEN Broncos+2.5 (-110)+110U 42.5 (-110)
TeamSpreadMoneylineTotal
DET Lions+4.5 (-115)+175O 51.5 (-110)
LA Rams-4.5 (-105)-210U 51.5 (-110)
TeamSpreadMoneylineTotal
CAR Panthers-3.0 (-105)-155O 40.5 (-105)
NO Saints+3.0 (-115)+130U 40.5 (-115)
TeamSpreadMoneylineTotal
TEN Titans+12.5 (-110)+600O 42.5 (-115)
SF 49ers-12.5 (-110)-900U 42.5 (-105)
TeamSpreadMoneylineTotal
IND Colts+3.5 (-110)+154O 46.5 (-110)
SEA Seahawks-3.5 (-110)-185U 46.5 (-110)
TeamSpreadMoneylineTotal
MIN Vikings+6.5 (-105)+275O 47.5 (-110)
DAL Cowboys-6.5 (-115)-345U 47.5 (-110)
TeamSpreadMoneylineTotal
MIA Dolphins+3.5 (-108)+160O 41.5 (-112)
PIT Steelers-3.5 (-112)-192U 41.5 (-108)

The biggest spread on the board is shared between two games: the 49ers are laying 12.5 at home to the one-win Titans, who are currently in line to get the first-overall pick for the second straight season. The Eagles are also laying 12.5 points at home against the two-win Raiders.

The highest total on the board is also shared between a pair of games: both Ravens/Bengals and Lions/Rams have opened with game totals of 51.5 in the Week 15 NFL odds.

The lowest total on the board is 39.5 in Browns vs Bears.

Odds as of Dec. 7th at bet365 and DraftKings. Claim the latest offers and sign-up bonuses from bet365 Missouri before wagering on NFL Week 15.

Opening Chargers vs Chiefs Odds

In what will amount to another de facto must-win game for Kansas City, the Chiefs (6-6, 5-1 home) have opened as 4.5-point home chalk against the AFC West-rival LA Chargers (8-4, 3-2 away).

Kansas City is currently the #10 seed in the AFC ahead of their SNF clash with the Houston Texans (one of the teams they need to leapfrog to get back into a postseason position) in Week 14.

Opening Packers vs Broncos Odds

A fascinating interconference clash sees the 8-3-1 Green Bay Packers visiting the 10-2 Denver Broncos. Both teams still have their eyes on the #1 seed (and lone bye) in their respective divisions. The Broncos are trying to track down the 11-2 New England Patriots, while the Packers are chasing the 9-3 Chicago Bears.

The Packers have opened as slight road favorites at Denver (-2.5) despite the Broncos’ perfect 6-0 home record through Week 14.

Opening Bills vs Patriots Odds

Arguably the best game of the week sees the soon-to-be 9-4 Buffalo Bills visiting the 11-2 New England Patriots. A win for New England would wrap up the NFC East.

Riding an NFL-best ten-game win streak and coming off a bye, the Pats have opened as slim 1.5-point home favorites. and -118 chalk on the moneyline. The Patriots already beat the Bills 23-20 in Buffalo back in Week 5.

Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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