Opening NFL Week 18 Odds – Spread, Total, Moneyline for Final Week

• The NFL Week 18 odds have been posted
• Several teams are expected to rest starters in the final week of the season
• See the NFL Week 18 odds, including the spread, total, and moneyline for all 16 games on the schedule

As we enter the final week of the NFL regular season, some teams are battling for postseason berths/positioning, while others are playing out the string. The NFL Week 18 odds are usually the slowest to come out due to the potential for starters to be stapled to the bench.

But the lines for several games have already been posted, and the rest will follow eventually. The table below lists the opening NFL Week 18 odds for all games currently on the board. More lines will be added as they become available. There are no TNF odds or MNF odds in Week 18 as all 16 games will take place on Sunday, Jan. 4th.

NFL Week 18 Odds

Odds as of Dec. 28 at bet365, DraftKings, and FanDuel. Download the top NFL betting apps for the 2026 playoffs.

Opening Panthers vs Buccaneers Odds

The Panthers and Buccaneers both lost in Week 17, setting up a winner-take-all battle for the NFC South title in Week 18. Like the AFC North, only the division-winner is going to make the postseason.

Tampa Bay has opened as a 3.5-point home favorite. The Panthers took the first meeting between the teams (23-20) at home just one week ago.

Opening Ravens vs Steelers Odds

Pittsburgh’s loss at Cleveland on Sunday afternoon means that the Week 18 tilt between the Ravens and Steelers will be for the AFC North title and the division’s lone berth in the NFL playoff bracket.

Despite Pittsburgh having home-field advantage, Baltimore has opened as a three-point road favorite. The Steelers won 27-22 in Baltimore back in Week 14 as 5.5-point road underdogs.

Opening Seahawks vs 49ers Odds

If the 49ers beat the Bears on Sunday Night Football tonight, then the Week 18 clash between San Francisco and Seattle will be for the NFC West crown and, potentially, the #1 seed in the NFC.

The line has opened as a near pick’em, with the 49ers listed as -110 moneyline chalk and the Seahawks as the narrowest of underdogs at -106. Seattle won the first meeting of the season at home, all the way back in Week 1 (17-13).

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