Razorbacks Sweet 16 Underdogs – Opening Odds for #4 Arkansas vs #1 Arizona

• #1 Arizona meets #4 Arkansas in a chalky West Region Sweet 16 matchup
• The teams have combined for 17 straight wins
• See the opening Arkansas vs Arizona odds for Thursday’s game in San Jose

It’s all chalk at the top of the bracket in the West Region. The #1 Arizona Wildcats (34-2 SU, 20-15-1 ATS) will face the #4 Arkansas Razorbacks (28-8 SU, 23-13 ATS) on Thursday, March 26th, at the SAP Center in San Jose, CA.

In a game that will feature three of the best freshmen in the country – Arkansas’ Darius Acuff Jr and Arizona’s Koa Peat and Brayden Burries – the Wildcats have opened as significant betting favorites.

Arkansas vs Arizona Opening Odds

The Arizona/Arkansas spread lists Zona as a 7.5-point favorite. On the moneyline, Arizona is a -280 favorite to advance to the Elite Eight.

Arkansas comes back as a +225 underdog. The O/U has opened at 164.5 with -110 odds both ways.

Odds as of March 22nd. Find the best betting app for the 2026 NCAA Tournament.

The March Madness championship odds currently list Arizona as the outright favorite. The Wildcats are trading at 22¢ (equivalent to +355 odds). Arkansas is trading at just 3¢ (equivalent to +3233 odds).

Arizona vs Arkansas Key Stats

Arizona advanced to the Sweet 16 with a 78-66 win over #9 Utah State, powered by an 18-point performance from Big 12 Player of the Year Jaden Bradley and 14 rebounds from Matas Krivas.

Arkansas outlasted #12 High Point (94-88) in an absolute track meet. Freshman sensation Darius Acuff Jr was sensational once again, with 36 points on 50% shooting. He’s now scored 24 or more points in six straight games, boosting his draft stock by the minute.

According to Sportradar data, these schools haven’t met since 1994.

The winner of Arkansas/Arizona will face the winner of #11 Texas vs #2 Purdue in the Elite Eight on Saturday, March 28th.

Bookmark SBD’s college basketball odds page to see the latest lines from every March Madness game.