Huskies Favored Over Spartans in Sweet 16 – Opening Michigan State vs UConn Odds

Published: March 22, 2026 at 11:29 pm EDT

UConn Huskies forward Alex Karaban high-fiving guard Braylon Mullins — Mar 22, 2026; Philadelphia, PA, USA; UConn Huskies forward Alex Karaban (11) and guard Braylon Mullins (24) react in the second half during a second round game of the men's 2026 NCAA Tournament at Xfinity Mobile Arena. Mandatory Credit: Kyle Ross-Imagn Images

The #2 UConn Huskies will face the #3 Michigan State Spartans in the Sweet 16
UConn and Michigan are separated by just one spot at KenPom
See the opening UConn vs Michigan State odds

Another region, more chalk. The #2 UConn Huskies (31-5 SU, 14-22 ATS) and #3 Michigan State Spartans (27-7 SU, 17-15-2 ATS) will meet in the East Region Sweet 16 at Capital One Arena in Washington, DC, on Friday, March 27th. Tip-off is scheduled for 9:45 pm ET.

Every analytics site projects a razor-thin margin. The opening Michigan State/UConn odds follow suit, listing the Huskies as miniscule favorites.

Michigan State vs UConn Odds (Sweet 16)

Bet Type	MSU	UConn
Spread	+1.5 (-125)	-1.5 (+102)
Moneyline	48¢ / +108	53¢ / -113
Total	O 135.5 (-110)	U 135.5 (-110)

At prediction site Kalshi, UConn is trading at 53¢ to reach the Elite Eight (equal to -113 odds) while MSU is trading at 48¢ (+108 odds).

UConn is a 1.5-point ATS favorite at FanDuel, but are priced at +102 to cover that number. MSU -1.5 is a short -125. The game total has opened at 135.5 with -110 odds on both the over and under.

Odds as of March 22. Download the sports betting apps for March Madness.

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The Huskies and Spartans are almost even in the March Madness championship odds. At DraftKings, UConn is priced at +2500 and Michigan State at +3000. Both teams are trading at 3 at prediction site Kalshi, which is equal to +3233 odds.

Michigan State has posted two convincing wins in the tournament, running over #14 North Dakota State (92-67) before handling #6 Louisville (77-69). Jeremy Fears Jr has dished out 27 assists through two games.

UConn was pushed some by #15 Furman (82-71) and then blew past shorthanded #7 UCLA in the second round (73-57).

UConn vs Michigan State Team Stats

UConn	Stat	MSU
30-5	W-L	27-7
77.6	PPG	79.3
65.3	OPP PPG	68.4
48.3	FG%	47.4
8.2	3PM/G	7.8
23.7	3PA/G	21.4
34.7	3P%	36.5
71.6	FT%	76.5
36.8	RPG	39.7
10.1	ORPG	10.8
23.3	DRPG	25.9
18.5	APG	18.8
6.9	SPG	5.1
5.1	BPG	4.2
10.3	TOPG	10.9

The winner of Michigan State vs UConn will advance to face the winner of #1 Duke vs #5 St John’s in the Elite Eight on Sunday, March 29th.

Michigan State and UConn haven’t met since the 2021-22 season, when Tom Izzo’s Spartans won 64-60 on a neutral court in the Bahamas.

Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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Huskies Favored Over Spartans in Sweet 16 – Opening Michigan State vs UConn Odds

Michigan State vs UConn Odds (Sweet 16)

UConn vs Michigan State Team Stats

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