NFL Week 4 Injury Report: Latest Betting Updates on Caleb Williams, Justin Jefferson & Puka Nacua

• Star receivers Justin Jefferson and DeVonta Smith are out this week
• Lamar Jackson and Patrick Mahomes popped up on the injury report, but neither has a designation for Sunday; they are good to go
• Continue reading for a breakdown of the Week 4 injury report

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Welcome to Week 4 of the 2026 NFL season. As the grueling schedule starts taking a toll, injury reports are becoming a key aspect of my handicapping process. Navigating these murky waters can mean the difference between cashing a ticket and tearing one up.

This week’s practice reports feature major names that will scramble player prop projections and shift moneylines. I am keeping a close eye on stars like Chicago Bears quarterback Caleb Williams and Minnesota Vikings wideout Justin Jefferson. Both have already been ruled out, which should set off alarms for bettors checking the latest NFL odds.

Meanwhile, the Los Angeles Rams are monitoring Puka Nacua, who has missed the last two weeks. Massive injury lists are also piling up for battered rosters like the Washington Commanders, Philadelphia Eagles, and Tampa Bay Buccaneers. Whether you are finalizing DFS lineups, checking NFL ATS records to attack the spread, or hunting for hidden value, knowing exactly who is taking the field is your greatest edge. Let’s dive into the Week 4 injury landscape to uncover the actionable advice shaping this weekend’s board.

NFL Week 4 Injury Report & Designations

Here’s how the key updates affect the matchups and markets discussed below.

Caleb Williams, QB, Bears

Williams is out for the second week in a row after missing practice with a hamstring issue. The Bears are currently laying -3.5 points (-111) at home against the Jets with a moneyline of -182.

Factoring in standard juice, the article’s vig-free implied probability gives the Bears a 61.93% chance to win outright, leaving the Jets at 38.07%. Chicago is turning to either Tyson Bagent or Case Keenum, which could put pressure on the -3.5 spread and the game total of 43. Wait for a final status update before treating his absence as certain.

Keenum started in Week 3 after Bagent had a week in concussion protocol. Ben Johnson has yet to announce a starter, leaving some ambiguity that the Jets must deal with. Bagent is a more athletic option, while Keenum is the classic veteran “coach on the field” quarterback.

See latest Jets vs Bears odds

Justin Jefferson, WR, Vikings

Jefferson is now listed out with an ankle injury after missing practice. The Vikings are -10.5-point favorites with a -588 moneyline against the Miami Dolphins. Stripping the juice, the article’s vig-free probability puts Minnesota at 81.77% to win and Miami at 18.23%.

Minnesota will have to play without its leading receiving threat, a confirmed absence that could affect its passing game and receiving-prop markets. The game total is 38.5; reassess the matchup and available player props with Jefferson ruled out.

Jordan Addison and Jauan Jennings should see an increased target share in the Minnesota offense. It could also be a low-volume passing attack as the Vikings are huge favorites.

See latest Dolphins vs Vikings odds

Baker Mayfield, QB, Buccaneers

Mayfield is out with a thumb injury after missing practice, confirming that Tampa Bay will be without its starting quarterback. The Buccaneers are +3.5 home underdogs at +155 on the moneyline against the Green Bay Packers. The article’s vig-free calculation gives Tampa Bay a 37.66% chance to win and Green Bay 62.34%.

With Mayfield ruled out, the Packers’ -3.5 spread and the 39.5-point total warrant a fresh look; the earlier expectation of a possible absence is no longer conditional. The effect on the market will depend on how Tampa Bay’s replacement performs and how bookmakers adjust their prices.

The Bucs will turn to undrafted rookie Jalon Daniels. Daniels has a big arm and plus-level mobility, but the down-to-down effectiveness left many scouts wanting more during Daniels’ career at Kansas.

See latest Packers vs Buccaneers odds

Nico Collins, WR, Texans

Collins is finally slated to play after missing the last two weeks. The Texans are favored by a field goal (-3, -111) at home, with a game total of 48. The 0-3 Texans must start racking up the wins with a purpose to get back into the playoff hunt.

See latest Cowboys vs Texans odds

Jayden Daniels, QB, Commanders

Daniels is out with an elbow injury after limited participation in practice. Washington will be start Marcus Mariota against Indianapolis, his second start in a row.

Mariota led Washington to an unbelievable upset over the reigning champion Seahawks. Mariota is a solid facsimile for Daniels with his athleticism in the pocket and adequate rushing ability. Throw for throw since 2025 began, Mariota has likely played better, although Daniels’ 2024 showed even more potential.

See latest Colts vs Commanders odds

Breece Hall, RB, Jets

Hall is out with a quad injury after missing practice. His absence removes a key option from New York’s backfield against Chicago and should be considered when evaluating the Jets’ rushing and receiving props, as well as the overall matchup. Braelon Allen should get most of the workload in Hall’s absence.

DeVonta Smith, WR, Eagles

Smith is out with a hamstring injury after missing practice. Smith was on the injury report last week before suiting up for Monday Night Football. The Eagles will also be without Dallas Goedert and Hollywood Brown on Sunday. Look for Philly to rely on the ground attack and feed targets to Dontayvion Wicks and Makai Lemon.

See latest Rams vs Eagles odds