NBA DFS Picks Today: October 21, 2026: Best Picks

• The NBA continues Wednesday, October 21, with an exciting 11-game slate and plenty of DFS opportunities.
• Today’s NBA DFS picks feature three star players: Anthony Edwards, Paolo Banchero, and Luka Doncic.
• Our picks are backed by player stats and season averages, targeting points and combined points, rebounds, and assists props on Splash Sports, Dabble, and Underdog.

After the NBA season opener, we have an 11-game slate on Wednesday, October 21! With a full night of basketball ahead, there are plenty of opportunities to find value in NBA DFS contests and player props.

Our picks feature Anthony Edwards, Paolo Banchero, and Luka Doncic. We’re using season statistics, recent production, and player roles to identify three props worth considering on Splash Sports, Dabble, and Underdog.

NBA DFS Picks for October 21, 2026

NBA DFS Picks Overview

Anthony Edwards More 27.5 Points

Anthony Edwards enters the new season as Minnesota’s primary scoring threat, making his 27.5-point projection an appealing target. He averaged 28.8 points per game during the 2025-26 regular season, putting his scoring average 1.3 points above this line. Edwards also averaged 5.0 rebounds and 3.7 assists per game, showing he can contribute beyond scoring.

The mixed shooting results are worth noting, but Edwards’ established scoring average provides a strong statistical foundation for this pick. He needs at least 28 points to cash the over against Miami. If he receives his usual workload and finds his rhythm from the perimeter, he has the scoring ability to clear the projection.

Paolo Banchero More 23.5 Points

Paolo Banchero is another player to consider on Wednesday’s slate as Orlando prepares to face Atlanta. The Magic forward averaged 22.2 points, 8.4 rebounds, and 5.2 assists per game across 72 regular-season appearances in 2025-26. His scoring average sits 1.3 points below the 23.5-point projection, so he’ll need to outperform his previous season’s baseline to hit this over.

Banchero also contributes as a rebounder and playmaker, but this prop depends exclusively on his scoring output. He’ll need 24 points to cash, making shot volume, free-throw opportunities, and his efficiency against Atlanta key factors to monitor.

Luka Doncic More 48.5 Points + Rebounds + Assists

Luka Doncic’s points, rebounds, and assists combination offers multiple ways to reach the required total. During the 2025-26 regular season, he averaged 33.5 points, 7.7 rebounds, and 8.3 assists per game with the Los Angeles Lakers. Those numbers combine for 49.5 PRA per game, putting his average one point above Wednesday’s 48.5 projection.

The main consideration is that the margin between his previous season’s average and this projection is relatively small. A dip in minutes or shooting efficiency could put the over in jeopardy, so his availability and expected workload are important to check before tipoff.

Still, Doncic’s all-around production makes this an intriguing option for the Lakers’ matchup against Golden State. He needs a combined 49 points, rebounds, and assists to cash the over.

NBA DraftKings DFS Lineup 10/21

Here’s my DraftKings DFS lineup ahead of tonight’s 11-game slate!