Opening Week 10 College Football Odds, Spreads & Lines: BYU vs Utah & More

• Utah is a short home favorite over BYU in the early Week 10 college football odds
• Alabama vs LSU and Kentucky vs Tennessee are also on the board
• See the opening spreads, totals and moneylines for all matchups below

BYU at Utah leads the early Week 10 college football odds, with the Utes laying 4.5 in the Holy War. Kickoff is noon ET on Nov. 7, and BYU’s official schedule still lists the network as ABC or ESPN.

The Week 10 board runs from Tuesday MACtion through Saturday’s rivalry games. More spreads, totals and moneylines will be added as they become available, and it is worth measuring these numbers against the live college football odds as that happens.

Opening Week 10 College Football Odds

Early Week 10 odds from DraftKings, captured Nov. 1. Get the best prices with our College Football betting apps.

Toledo is the biggest favorite in the opening Week 10 CFB odds above at -27.5, while UTSA vs Florida Atlantic has the highest total at 71.5.

BYU vs Utah Odds

The BYU vs Utah odds have the Utes at -4.5 with a 48.5 total, Utah at -175 and BYU at +145. Both teams come in off wins, but they arrived in very different ways.

Utah is 8-0 after a 49-25 win over Cincinnati, piling up 534 total yards with 268 of those on the ground. Devon Dampier threw for 260 yards and three touchdowns in that one.

BYU moved to 7-1 by beating Arizona State 27-20, though the Cougars managed only 47 rushing yards. Bear Bachmeier went 19 of 30 for 236 yards and a touchdown, and Sione Moa scored twice on the ground.

BYU will need more from its running game in Salt Lake City. Utah enters unbeaten, but the 4.5-point spread leaves room for a close rivalry game.

Alabama vs LSU Odds

The Alabama vs LSU odds list the Tigers at -4.5 with a 52.5 total, LSU at -175 and Alabama at +145. Alabama’s official game center sets kickoff for 3:30 pm ET on ABC in Baton Rouge.

Both teams were idle on Oct. 31, so each has had two weeks to prepare. LSU’s last outing was a 38-17 win over Auburn on Oct. 24, with Sam Leavitt going 32 of 45 for 387 yards and three touchdowns without an interception.

The Tigers also recorded seven sacks in that game, giving Alabama another concern beyond slowing Leavitt. DraftKings has LSU -4.5 (-105) and Alabama +4.5 (-115), while BetMGM has LSU -4 (-105) and Alabama +4 (-114). That half point is worth checking before choosing a side.

Kentucky vs Tennessee Spread

The Kentucky vs Tennessee spread has the Volunteers laying 5.5 at home with a 50.5 total, Tennessee at -198 and Kentucky at +164. Tennessee’s official schedule puts kickoff at 6:15 pm ET.

Tennessee is 6-2 and comes off a bye. Its most recent game was a 27-24 loss to South Carolina on Oct. 24, so the Vols have had an extra week to work through that one.

Tennessee is favored by less than a touchdown in this rivalry matchup. At -5.5, a six-point Volunteers win would be enough to cover; a move to -6 would turn that same result into a push.

Other Notable Week 10 CFB Odds

Georgia is a 3-point road favorite at Ole Miss, with a 56.5 total. The Bulldogs are -135 on the moneyline, while the Rebels are +114 to win at home.

Notre Dame is laying 3.5 against visiting Miami with a 55.5 total. Ohio State is a larger home favorite against Oregon at -10.5, with that Big Ten matchup carrying a 45.5 total.

Texas is favored by 3.5 at Missouri, with the total at 48.5. Those Week 10 CFB lines join the full early board above, which will be updated as additional games become available.