Opening NFL Week 11 Odds – Spread, Total, Moneyline for All 13 Games
By Sascha Paruk in NFL News
Published:
- The NFL Week 11 odds are out
- Six teams are on bye, leaving just 13 games on the Week 11 slate
- See the opening NFL Week 11 odds including spread, total, and moneyline for every game
The NFL Week 11 odds are out at online sportsbooks. Week 11 starts with a lackluster TNF matchup between the Colts (3-7) and Texans (3-6) in Houston, and wraps with a MNF clash between the Bengals (6-2) and Commanders (3-5-1). The Sunday nighter is the best of the bunch as the 49ers (7-1) and Vikings (7-2) clash in Mexico City on Nov. 22.
The table below lists the opening NFL Week 11 odds for all 13 games. The six teams on bye are: Browns, Falcons, Packers, Patriots, Rams, Seahawks.
NFL Week 11 Odds – Opening Lines
Odds as of Nov 15 at DraftKings. Download the best NFL betting apps ahead of Week 11.
Opening Colts at Texans Odds
Date/Time: Thu, Nov 19 – 8:15 PM ET
Opening Lines: Texans -9.5 (-115) | Over/Under 44.5 (-110) | Moneyline: Colts +350 / Texans -455
An AFC South rivalry opens Week 11 on Thursday night as Anthony Richardson and the Indianapolis Colts (3-7 SU, 5-5 ATS, 6-4 O/U) head to Reliant Stadium to take on C.J. Stroud and the Houston Texans (3-6 SU, 3-6 ATS, 6-3 O/U). Oddsmakers have positioned Houston as a commanding 9.5-point home favorite, with the game total opening at 44.5 points.
Both divisional foes have leaned heavily to the high side this season with identical six-over records, setting up an intriguing prime-time battle where Houston looks to climb back into the division picture behind Stroud’s home efficiency.
Opening Saints at Bears Odds
Date/Time: Sun, Nov 22 – 1:00 PM ET
Opening Lines: Bears -9.5 (-110) | Over/Under 49.5 (-110) | Moneyline: Saints +360 / Bears -470
Soldier Field hosts an NFC matchup on Sunday afternoon as the New Orleans Saints (3-6 SU, 3-6 ATS, 5-4 O/U) travel north to clash with Caleb Williams and the surging Chicago Bears (7-2 SU, 6-3 ATS, 5-4 O/U). Chicago hits the board as a 9.5-point home favorite, while sportsbooks have set a high total of 49.5 points.
Chicago has been one of the NFL’s premier betting values this year by covering in six of nine contests, and Williams will look to keep the offense humming against a New Orleans secondary that has yielded five overs through nine outings.
Opening Steelers at Eagles Odds
Date/Time: Sun, Nov 22 – 1:00 PM ET
Opening Lines: Steelers -4.5 (-110) | Over/Under 38.5 (-110) | Moneyline: Steelers -198 / Eagles +164
In-state bragging rights hang in the balance at Lincoln Financial Field as Aaron Rodgers and the Pittsburgh Steelers (6-2 SU, 6-2 ATS, 4-4 O/U) make the cross-state trip to square off against Jalen Hurts and the Philadelphia Eagles (2-7 SU, 1-8 ATS, 4-5 O/U). Bookmakers opened Pittsburgh as a 4.5-point road favorite, with a defensive-minded total of 38.5 points marking the lowest figure on the board.
Pittsburgh enters as one of the league’s sharpest covers at 6-2 ATS, while Philadelphia seeks answers after dropping seven of its first nine games and managing just one cover all season against spread numbers tracked since 2011.
Opening Buccaneers at Lions Odds
Date/Time: Sun, Nov 22 – 1:00 PM ET
Opening Lines: Lions -6 (-110) | Over/Under 46.5 (-110) | Moneyline: Buccaneers +210 / Lions -258
Ford Field serves as the stage for an explosive NFC tilt as Baker Mayfield and the Tampa Bay Buccaneers (3-6 SU, 4-5 ATS, 5-4 O/U) pay a visit to Jared Goff and the Detroit Lions (7-2 SU, 4-4-1 ATS, 5-4 O/U). Oddsmakers opened Detroit as a 6-point home favorite, accompanied by a total of 46.5 points.
The Lions enter this midseason showdown having won seven of their first nine games outright, but they face a battle-tested Tampa Bay squad capable of creating big-play opportunities through Mayfield’s downfield passing game indoors.
Opening Bengals at Commanders Odds
Date/Time: Mon, Nov 23 – 8:15 PM ET)
Opening Lines: Bengals -3.5 (-115) | Over/Under 51.5 (-110) | Moneyline: Bengals -205 / Commanders +170
A cross-conference shootout occupies the Monday night timeslot as Joe Burrow and the Cincinnati Bengals (6-2 SU, 5-3 ATS, 6-2 O/U) travel to Northwest Stadium to take on Jayden Daniels and the Washington Commanders (3-5-1 SU, 4-4-1 ATS, 5-4 O/U). Oddsmakers have installed Cincinnati as a 3.5-point road favorite, while the 51.5-point total stands as the second-highest mark on the opening board (after Titans/Cowboys at 52.5).
With both passing offenses ranking among the league leaders in explosive play rate and red-zone touchdown efficiency, expect plenty of fireworks under the Monday night lights.
Opening Vikings at 49ers Odds
Date/Time: Sun, Nov 22 – 8:20 PM ET
Opening Lines: 49ers -3.5 (-102) | Over/Under 46.5 (-110) | Moneyline: Vikings +154 / 49ers -185
Sunday Night Football heads south of the border to Estadio Banorte in Mexico City for a heavyweight NFC duel between Kirk Cousins and the Minnesota Vikings (7-2 SU, 5-4 ATS, 1-8 O/U) and Brock Purdy and the San Francisco 49ers (7-1-1 SU, 5-4 ATS, 4-5 O/U). Oddsmakers have positioned San Francisco as a 3.5-point favorite on the neutral field, while setting the game total at 46.5 points.
Both seven-win contenders have rewarded backers with identical 5-4 ATS marks this season in betting data tracked since 2011, though Minnesota brings an elite defensive unit that has produced an NFL-leading eight unders through nine games to test Kyle Shanahan’s high-efficiency offense at altitude.
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Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
