Sandy Ryan vs Mikaela Mayer Prediction, Odds & How to Watch (Friday, Sep. 27)

By Brady Trettenero in Boxing
Updated: September 27, 2024 at 1:39 am EDTPublished:

- Sandy Ryan defends her WBO welterweight title against Mikaela Mayer on Friday, September 27
- The latest Friday night boxing odds slightly favor the champion Ryan at -125
- Read below for Ryan vs Mayer prediction, odds, and tale of the tape
The Theater at Madison Square Garden in New York City hosts a can’t-miss women’s boxing clash on Friday night. WBO welterweight champ Sandy Ryan defends her title against former unified super featherweight queen Mikaela Mayer.
Oddsmakers see this as a 50/50 fight, and it’s easy to see why.
Fight Details
- Date: Friday, September 27, 2024
- Venue: The Theater at Madison Square Garden, New York City
- Main Card Start: 10:30 p.m. ET
- Main Event Ring Walks: Around midnight ET
- Watch On: ESPN+ (U.S.)
Betting Odds
- Sandy Ryan: -125
- Mikaela Mayer: +110
- Over/Under: 8.5 Rounds
Sandy Ryan enters as a slight -125 favorite, with Mikaela Mayer a +110 underdog. This is a true 50/50 matchup, with oddsmakers giving Ryan a small edge.
The total rounds are set at 8.5, with the over heavily favored at -950, indicating an expectation that this bout will go the distance.

The Champ: Sandy Ryan
31-year-old Sandy Ryan (7-1-1, 3 KOs) from Derby, England, has been on a roll since going pro in 2021. She won Commonwealth Games gold and World Championships silver as an amateur. In April 2023, Ryan claimed the WBO welterweight title. She’s defended it twice, recently stopping ex-champ Terri Harper in round 4.
"It won't go the distance!" 💥🥊
Sandy Ryan is feeling CONFIDENT ✅#RyanMayer | Saturday, 2am pic.twitter.com/kimhlj7wGs
— Sky Sports Boxing (@SkySportsBoxing) September 26, 2024
Ryan’s only pro loss was a split decision to Erica Farias in her 4th fight. She got revenge five months later. In her U.S. debut last year, “The Sandstorm” drew with Jessica McCaskill, but most people thought Ryan won clearly.
As a natural welterweight, Ryan will be the bigger, stronger fighter against Mayer. Expect her to pressure Mayer, using her jab to set up power punches. If she traps Mayer on the ropes, it could end quickly.
The Challenger: Mikaela Mayer
Mikaela Mayer (19-2, 5 KOs) was a 2016 Olympian. The California native started her pro career at 130 pounds, becoming a unified champ. In 2022, she lost a close split decision to rival Alycia Baumgardner. Since then, the 34-year-old has jumped up the scales, fighting at 135, 140, and 147 pounds.

In January, Mayer got her first welterweight title shot but lost a debatable split decision to IBF champ Natasha Jonas in England. Many thought Mayer did enough to win.
To beat Ryan, Mayer needs to use her speed and movement. She’ll try to outbox Ryan, scoring with quick combos while avoiding slugfests. If she can frustrate Ryan and rack up points, a decision win is possible.
7-1-1 | Record | 19-2 |
3 | Knockouts | 5 |
5’9″ (175 cm) | Height | 5’9″ (175 cm) |
67″ (170 cm) | Reach | 66″ (168 cm) |
Orthodox | Stance | Orthodox |
Ryan vs Mayer Prediction
In a 50/50 fight, predicting a draw at +1600 odds is tempting. But after really analyzing each fighter’s strengths and styles, I’m picking the champ to keep her title.
Ryan’s welterweight experience and punching power will be key. She’s bigger than Mayer and won’t get pushed around. Her pressure will give Mayer all kinds of problems.
— Sandy Ryan (@sandyryan93) September 25, 2024
Mayer is tough, but she doesn’t hit hard enough to earn Ryan’s respect and keep her off. Unless Mayer can stick and move perfectly for all 10 rounds, Ryan’s size will take over as the fight goes on.
Expect back-and-forth action, but in the late rounds, Ryan should take control, landing heavy shots on a tiring Mayer. I predict Sandy Ryan will retain her WBO welterweight title by a split or majority decision.
For a little extra value, think about betting on Ryan to win by split decision at +500 odds. And if you feel lucky, throw a few bucks on that +1600 draw prop – just in case they’re even after 10 rounds of non-stop action.
Friday Boxing Picks:
- Sandy Ryan by Split Decision (+550 at DraftKings)
- Sprinkle Bet: Draw as Exact Method of Victory (+1600 at FanDuel)
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Lead NHL & NCAAF Editor
Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.