Week 4 College Football Picks Against the Spread

By Blair Johnson in College Football
Updated: September 19, 2024 at 10:22 am EDTPublished:

- Week 4 of College Football features some intriguing games on Saturday, September 24th
- Florida vs Tennessee and Arkansas vs Texas A&M are among the marquee matchups
- Read below for the best ATS picks for Week 4 of the college football season
Week 4 of the 2022 College Football season features a pair of highly intriguing SEC matchups on Saturday, September 24th, with the game between No. 20 Florida and No. 11 Tennessee being the headliner.
In addition to the showdown on Rocky Top, No. 10 Arkansas has a chance to make a massive statement when it visits No. 23 Texas A&M. Meantime, a pair of ranked ACC opponents — No. 5 Clemson and No. 21 Wake Forest — clash in Winston-Salem.
Here are CFB betting odds and three ATS picks to consider for Week 4.
Florida vs Tennessee Odds
Team | Spread | Moneyline | Total |
---|---|---|---|
Florida Gators | +11.5 (-109) | +290 | O 62.5 (-108) |
Tennessee Volunteers | -11.5 (-112) | -385 | U 62.5 (-113) |
All odds as of September 20th. See the available ESPN Bet promo code for new users today.
ATS Pick #1: Florida (+11.5) vs Tennessee
The Volunteers enter Saturday’s tilt with the Gators as the biggest favorite they’ve been in at least 25 years of the rivalry series. A big reason why is because UT has passed the eyeball test so far in 2022. The Vols blew out Ball State and Akron by a combined score of 122-16 and beat defending ACC champion Pittsburgh 34-27 on the road in overtime. Meantime, UF got past then-No. 7 Utah at home in the opener, but lost to Kentucky and nearly slipped up against South Florida. Now, the Gators have their first road game in a series they’ve won 16 of the last 17 games in.
It’s refreshing to hear Josh Heupel not act like Florida is just any other game for Tennessee pic.twitter.com/bnmHDTmZjJ
— zach ragan (@zachTNT) September 19, 2022
Heupel’s senior quarterback, Hendon Hooker, has been steady as expected through the first three games. But his top target (Cedric Tillman) and top running back (Jabari Small) both went down with injuries early against the Zips in Week 3. Both situations — especially Tillman’s — will need to be closely monitored leading up to kickoff. The dynamic Tillman is currently listed as day-to-day with a high ankle injury and is “questionable” for Saturday.
Meantime following a breakout performance against the Utes in Week 1 (168 yards passing, 106 yards rushing, three touchdowns accounted for), Florida quarterback Anthony Richardson has crashed back down to earth over the last two weeks. He’s tossed just a total of 423 passing yards this season and was brutal against UK (24-of-53 through the air, zero touchdowns and four interceptions). However, his legs could be the difference at Neyland. Gators head coach Billy Napier has confidence in his signal caller.
Florida coach Billy Napier on QB Anthony Richardson’s 1st SEC road start at Tennessee: “It's not like we're going to Canada & they're going to change the rules. It's going to be the same game. It's going to be a little louder & played at a different location”
— Brett McMurphy (@Brett_McMurphy) September 19, 2022
On defense, UT is giving up just over 14 points per game, down from 29 per contest last season. The Vols are also allowing opponents 24% on third-down conversions, down from 42% in 2021. But it’s all come against the two worst teams in the MAC and a Pitt squad that was without its starting quarterback for most of the second half. Translation: we don’t really know how good this group is yet.
Vols Total Offense Rank: 3
Gators Total Defense Rank: 76Gators Total Offense Rank: 98
Vols Total Defense Rank: 52This Saturday is going to be fun.
— Xoom Sports (@LegendsCigarCo) September 21, 2022
Tillman is an X-factor. If he can go, the home team should cover. But if he can’t — or even if he’s not at 100% (which it seems like he won’t be) — watch out. Florida has been a thorn in Tennessee’s side for years. That could be the case once again in Knoxville.
- Pick: Florida +11.5 (-109)
Arkansas vs Texas A&M Odds
Team | Spread | Moneyline | Total |
---|---|---|---|
Arkansas Razorbacks | +2.5 (-112) | +105 | O 48.5 (-109) |
Texas A&M Aggies | -2.5 (-109) | -129 | U 48.5 (-112) |
ATS Pick #2: Arkansas vs Texas A&M (-2.5)
Prior to last year’s 20-10 victory in Arlington, the Hogs had lost nine straight times to the Aggies. Saturday’s tilt is back at Jerry World as Jimbo Fisher’s group continues its recovery from a devastating home loss to Appalachian State.
Last time we visited Dallas was pretty fun. Right @RoyalGreen25? 🔄 pic.twitter.com/9EFyXZpDUW
— Arkansas Razorback Football (@RazorbackFB) September 20, 2022
With LSU transfer Max Johnson now at quarterback, A&M is averaging just 21 points per game. On the bright side, the Aggies are only allowing 9 per outing, good for ninth nationally. Meantime, the Razorbacks are putting up 38 points per game — but allowing 28 (and their pass defense is the worst in FBS).
🏈WEEK 4 ADVANCED STATS PREVIEWS🏈
EVENING SLATE
ARKANSAS v TEXAS A&M pic.twitter.com/JyI0RLx0r8
— parker fleming (@statsowar) September 20, 2022
Arkansas is led by quarterback K.J. Jefferson (770 passing yards, six touchdowns, one interception) and running back Raheim “Rocket” Sanders (440 rushing yards). Don’t forget just two weeks ago, A&M was considered a sleeper CFP participant. I think Gig ‘Em gets ’em.
- Pick: Texas A&M -2.5 (-109)
Clemson vs Wake Forest Odds
Team | Spread | Moneyline | Total |
---|---|---|---|
Clemson Tigers | -7 (-110) | -265 | O 55.5 (-110) |
Wake Forest Demon Deacons | +7 (-110) | +200 | U 55.5 (-1010) |
ATS Pick #3: Clemson (-7) vs Wake Forest
The Tigers didn’t live up to expectations last year, but feel like they’re on their way back in 2022. Quarterback DJ Uiagalelei is coming along and Will Shipley gave the run game a huge spark with a 139-yard, two-touchdown performance against Louisiana Tech last week.
The Players I'm Most Excited To Watch This Weekend:
1. Sam Hartman (QB, Wake)
2. Jalon Daniels (QB, KU)
3. Marvin Harrison Jr. (WR, OSU)
4. Will Shipley (RB, Clemson)
5. Mohammed Ibrahim (RB, Minn)— Parker Gillam (@gillam_parker) September 21, 2022
Meantime, Wake’s offensive scheme is predicated on veteran QB Hartman putting the ball in the running back’s belly — then holding it there until he reads the defense and makes a decision on whether to pull it or hand it off. It’s called the mesh and it doesn’t work on the Tigers’ stout defense.
Look for Dabo’s boys to get a quality road win.
- Pick: Clemson -7 (-110)
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Sports Writer
Blair Johnson is a veteran journalist and seasoned sports content creator. He has been writing and producing content as long as he can remember, with such familiar names as CNN, NFL Media and Yahoo. Blair currently lives and works in the greater Los Angeles area.