Early ATS Picks for Week 6 College Football: Best Bets Against the Spread

• My early Week 6 college football ATS picks cover three marquee matchups, including the Red River Rivalry showdown
• I’m targeting a pair of favorites and one underdog on this card
• See my early ATS picks for Week 6 college football below, including the best bets against the spread

Week 6 on the college football calendar is highlighted by Alabama vs Georgia, the Red River Rivalry and a Friday night matchup in Provo. My early college football ATS picks focus on three spreads worth considering before the weekend.

These early picks weigh offensive efficiency, turnover differential and red-zone production. Those numbers help explain where I see an advantage beyond the rankings.

Below, I break down the college football odds and detail my favorite Week 6 college football best bets against the spread.

Early ATS Picks for Week 6 College Football

Odds as of October 6. Claim theScore bet promo code to lock in these lines.

Early Week 6 ATS Best Bet #1: Alabama vs Georgia Prediction

• Pick: Alabama -1.5 (-111 at theScore Bet)

The undefeated No. 6 Alabama Crimson Tide opened as home underdogs but have flipped to 1.5-point favorites. My Alabama vs Georgia prediction backs the home team to cover that small number in Tuscaloosa.

Both teams are legit National Championship odds contenders. Alabama features a dynamic offense that is absolutely lighting up the scoreboard with 49.2 points per game. They are moving the chains consistently, boasting a stellar 49.1% third down conversion rate. Their ground and pound identity helps them control the clock and keep opposing defenses on the field.

The real difference maker in this matchup is the turnover differential. Alabama sits at a massive +7 in turnover margin on the season. The No. 2 Georgia Bulldogs are a formidable opponent, but I expect the aggressive defensive schemes from Alabama to force crucial, momentum halting takeaways. Laying less than a field goal at home is tremendous value for a team protecting the football this well.

Early Week 6 ATS Best Bet #2: Texas vs Oklahoma Prediction

• Pick: Texas -8.5 (-106 at theScore Bet)

The top-ranked Texas Longhorns look to protect their No. 1 ranking as they head to the Cotton Bowl for the Red River Rivalry. My Texas vs Oklahoma prediction is for the Longhorns to cover the 8.5-point spread.

The Texas offense is an absolute machine right now. They are scoring 33.2 points per game and converting 50.0% of their third down attempts. Their pocket presence and ability to extend drives make them incredibly difficult to stop.

Conversely, Oklahoma struggles heavily to sustain drives on a consistent basis. They are eating empty possessions, converting a dismal 34.0% of their third down attempts while averaging just 22.0 points per game. Oklahoma also holds a costly -6 turnover differential. I expect Texas to win the field position battle and capitalize on those extra possessions to cover this spread. Before making any bet this weekend scan the best college football betting apps to find the best price.

Early Week 6 ATS Best Bet #3: Iowa State vs BYU Prediction

• Pick: Iowa State +10.5 (-111 at theScore Bet)

My Iowa State vs BYU prediction takes the double-digit underdog in Friday night’s Big 12 matchup. The No. 8 BYU Cougars originally opened as 14.5-point home favorites, but that number has come down to 10.5. I completely agree with the market sentiment backing the Iowa State Cyclones.

While BYU fields a high scoring offense, Iowa State is right on their heels averaging 33.6 points per contest.

The most compelling statistic for this matchup is red zone efficiency. Iowa State boasts a flawless 100.0% red zone conversion rate this season. That kind of elite execution in scoring position supports their ability to turn sustained drives into points. When you combine their scoring ability with their rock solid offensive execution, grabbing 10.5 points feels like an absolute steal.