Opening College Football Week 4 Odds, Including Auburn vs Oklahoma, Illinois vs Indiana Point Spreads

• The NCAAF Week 4 odds have been posted
• Four ranked-on-ranked matchups highlight the college football Week 4 betting lines
• See the opening college football Week 4 odds, including point spread, moneyline, and total for every game

Week 3 is in the books and the NCAAF Week 4 odds have started to trickle out at online sportsbooks. Week 4 is highlighted by four ranked-on-ranked games: #24 Auburn vs #13 Oklahoma, #9 Illinois vs #22 Indiana, #11 South Carolina vs #25 Missouri, and #21 Texas Tech vs #20 Utah. Three of those four games are battles of unbeatens.

The table below sets out the opening NCAAF Week 4 odds (spread, moneyline, and total) for every game on the board. More games and lines will be added as odds are posted.

College Football Week 4 Odds

There are some massive spreads on the board in the Week 4 college football odds, none higher than the 45.5-point line in Kent State vs Florida State.

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Week 4 will start with Rice vs Charlotte on Thursday, Sep. 18 (7:30 pm ET) before a pair of games on Friday, Sep. 19: Tulsa vs OK State (7:30 pm ET) and Iowa vs Rutgers (8:00 pm ET). No ranked teams are in action until Saturday, Sep. 20.

Bookmark SBD’s college football public betting percentages to see how the lines move over the course of the week and where the money is going in each matchup.

Florida vs Miami Odds Heavily Favor Hurricanes

The in-state battle between the SEC’s Florida Gators (1-2) and ACC’s Miami Hurricanes (3-0) has lost some of its preseason lustre after the Gators lost for the second straight week on Saturday, falling 20-10 at LSU, one week after getting upset 18-16 at home by South Florida as 18.5-point favorites.

The #5 Hurricanes just hammered that same USF team 49-12, easily covering as 17.5-point home chalk. Miami also owns a win over then-#6 Notre Dame (27-24) in Week 1 and is the top-ranked team from the ACC early in the season.

Miami has opened as an 8.5-point home favorite at Hard Rock Stadium in Miami Gardens. Florida vs Miami kicks off at 7:30 pm ET on Saturday, Sep. 20.

Auburn vs Oklahoma Spread Favors Sooners at Home

Arguably the game of the week sees #24 Auburn (3-0, 1-2 ATS) visiting #13 Oklahoma (3-0, 2-1 ATS) in Norman at 3:30 pm ET on Saturday in the first SEC game for both teams this season. OU has opened as a 4.5-point home favorite.

Both teams have faced on power-conference opponent so far. Oklahoma beat then-#15 Michigan (24-13) at home in Week 2, covering as four-point chalk. The Sooner also own lopsided wins over Illinois State (35-3 as 40.5-point favorites) and Temple (42-3 as 24-point favorites).

Auburn started the season with a 38-24 rout of Baylor as one-point road favorites. In Week 2, they beat Ball State 42-3 as 42.5-point home chalk. Last Saturday, they beat South Alabama 31-15 at home as 26.5-point favorites.