Opening Week 11 College Football Odds, Spreads & Lines: USC vs Indiana, Texas vs LSU & More

• Indiana opens as a touchdown favorite over USC in the Week 11 college football odds
• LSU lays 4.5 against Texas in Baton Rouge, while Georgia gives Missouri two touchdowns
• See the Week 11 opening spreads, totals and moneylines for the posted matchups below

USC gets a week off, a trip to Bloomington and seven points. Indiana opens as a touchdown favorite for Saturday’s Big Ten matchup, while LSU opens inside a touchdown at home against Texas. Those are two very different asks of the home favorites in Week 11.

There’s plenty on the board before either game kicks off. Ohio and Miami (OH) are separated by less than a field goal on Tuesday, and unbeaten UCLA has a Friday night date with Illinois at the Rose Bowl.

Here are the opening Week 11 college football odds from DraftKings. Our college football odds page has the latest lines as more games come on the board.

Opening Week 11 College Football Odds

Early Week 11 odds from DraftKings as of Nov. 8 ET. Away team listed first. Get the best prices with our College Football betting apps.

USC vs Indiana Opening Spread

Indiana is -7 at -115 in the USC vs Indiana odds, with the total at 49.5. USC had a bye after beating Ohio State 30-18. Indiana’s last game took overtime and a 60-yard field goal at the end of regulation just to get there. The Hoosiers beat Minnesota 23-16.

Seven is the number to follow before Saturday’s 3:30 p.m. ET kickoff. An Indiana win by exactly a touchdown sends both spread bets back at the opener. If the line ticks up to 7.5, that same result cashes a USC ticket.

Texas vs LSU Odds Put the Tigers at -4.5

DraftKings opened LSU at -4.5 (-105) and Texas at +4.5 (-115), with a total of 45.5. The Texas vs LSU spread falls between two common margins. A field-goal win in Baton Rouge is enough for LSU moneyline bettors at -175, but Texas would cover the spread.

LSU has to regroup after Alabama beat the Tigers 31-13. Texas is +145 to win outright, meaning bettors who like the Longhorns have two distinct ways to play a close game.

Missouri vs Georgia and the SEC Opening Lines

Georgia opens -14 at home against Missouri after putting up 42 on Ole Miss. Gunner Stockton threw four touchdown passes on just 15 attempts in Oxford, and the Bulldogs ran for 295 yards. At the Missouri vs Georgia line, a two-touchdown Georgia win lands right on the spread. The total is 47.5. DraftKings moved Georgia’s moneyline from -575 to -650 early Sunday while holding the spread at two touchdowns.

Ole Miss comes out of the same game laying 2.5 on the road against Oklahoma. Tennessee, meanwhile, opens -3 at Texas A&M after holding Kentucky out of the end zone in a 34-6 win. Those numbers put a three-point road win on opposite sides of the betting result: it cashes for Ole Miss and pushes for Tennessee.

Illinois vs UCLA Odds for Friday Night

UCLA is a 9.5-point favorite against Illinois on Friday night. The Bruins got to 9-0 with a 34-20 win at Minnesota, but the final margin hides how late they put it away.

It took two 75-yard touchdown passes from Ty Dieffenbach to Aidan Mizell in the fourth quarter to break open a tie. UCLA needs to win by 10 to cover the Illinois vs UCLA spread. Illinois is +285 on the moneyline, with the total at 47.5. Kickoff at the Rose Bowl is 9 p.m. ET on FOX.

Other Notable Week 11 College Football Odds

Oregon is an 8.5-point home favorite over Michigan with a 44.5 total. That’s a bigger spread than USC at Indiana, but the total is five points lower. The Ducks return to Eugene after scoring 41 in Columbus.

Miami is laying 15.5 to Duke after its first loss. Alabama opened as an even bigger road favorite at Vanderbilt, laying 19.5 after beating LSU 31-13. Both games carry totals north of 54, with Duke–Miami at 56.5 and Alabama–Vanderbilt at 54.5.