Opening Week 4 College Football Odds, Spreads & Lines: Oklahoma–Georgia, Oregon–USC
By Brady Trettenero in College Football
Updated: September 21, 2026 at 6:03 pm EDTPublished:
- Georgia is a two-touchdown favorite over Oklahoma in the opening Week 4 college football odds
- Oregon vs USC carries a 1.5-point spread and the highest total on the early board
- See early Week 4 odds, spreads and lines for 20 matchups below
Oklahoma at Georgia and Oregon at USC lead the opening Week 4 college football odds. The Bulldogs are laying 14 points in Athens, while the Trojans are just 1.5-point favorites in a game with a 62.5 total.
Texas visits Tennessee, LSU hosts Texas A&M, and Ole Miss heads to Florida after its win over the Tigers. The early board also includes Friday’s Northwestern–Indiana game and a low-total Big Ten matchup between Iowa and Michigan.
The table below covers all 20 games currently listed at DraftKings, with one row per matchup. Compare these early prices with the live college football odds as the week develops.
Week 4 College Football Odds
Early Week 4 odds from DraftKings as of Sep. 20; away team listed first. For sportsbook offers, see the current BetMGM promo code.
Oregon vs USC has the highest total on the early Week 4 board at 62.5, with the Trojans favored by just 1.5. Iowa vs Michigan sits at the opposite extreme with a 37.5 total, while Miami’s 42.5-point spread against Central Michigan is the largest.
Georgia is laying two touchdowns against Oklahoma, and Texas is a 5.5-point road favorite at Tennessee. Ole Miss–Florida and Oklahoma State–West Virginia join Oregon–USC among the tightest lines at 1.5 points.
Those close games are worth a price comparison on prediction market apps. Check available contracts at Kalshi and Polymarket before choosing where to take your side, comparing the same outcome and accounting for fees.
Oklahoma vs Georgia Odds
- Spread: Oklahoma +14 (-110) / Georgia -14 (-110)
- Total: 47.5 (Over -102 / Under -118)
- Moneyline: Oklahoma +470 / Georgia -650
Georgia hosts Oklahoma at 3:30 pm ET Saturday on ABC. The 14-point spread leaves a push if the Bulldogs win by exactly two touchdowns, while the 47.5 total implies roughly 31 points for Georgia and 17 for Oklahoma.
The Bulldogs improved to 3-0 with a 45-17 win at Arkansas, rushing for 254 yards on 42 attempts. Gunner Stockton completed 10 of 13 passes for 147 yards and a touchdown, then added 97 rushing yards. Oklahoma’s defense, meanwhile, carried it through a 14-6 win over New Mexico.
Oregon vs USC Odds
- Spread: Oregon +1.5 (-115) / USC -1.5 (-105)
- Total: 62.5 (Over -110 / Under -110)
- Moneyline: Oregon -105 / USC -115
Oregon at USC is one of the closest games on the board, but its 62.5 total is the highest of all 20. The combination puts both teams around 30 points, with very little separating them in the win market.
There is also a meaningful choice between the spread and moneyline. Oregon costs -105 to win outright or -115 with 1.5 points. USC is -115 to win and -105 laying 1.5, so bettors taking the spread save on the price but need the Trojans to win by at least two.
Texas vs Tennessee Odds
Texas is a 5.5-point road favorite at Tennessee, with a 57.5 total and a -218 moneyline. Tennessee comes back at +180. A touchdown victory covers for Texas, while a field-goal game would leave the Volunteers inside the spread.
Texas A&M vs LSU Odds
LSU is laying 8.5 at home after both teams lost Saturday. The Tigers fell 32-24 at Ole Miss, while Texas A&M lost 31-21 to Kentucky. LSU’s moneyline is -395, the Aggies are +310, and the total is 53.5.
A one-touchdown LSU win would cover for Texas A&M. The Aggies cost -115 with the points, compared with -105 to lay 8.5 with LSU, so the price of the spread matters alongside the margin.
Other Notable Week 4 Lines
Iowa at Michigan has the lowest total at 37.5, with the Wolverines favored by 4.5. At the other end of the spread range, Miami is laying 42.5 to Central Michigan. Ohio State and Notre Dame are each favored by 27.5 against Illinois and Purdue, respectively.
Florida is a 1.5-point home favorite over Ole Miss, matching the small spreads in Oregon–USC and Oklahoma State–West Virginia. Mississippi State is favored by three against Missouri, while Northwestern opens the listed slate Friday as a 23.5-point underdog at Indiana.
Lead NHL & NCAAF Editor
Brady is the lead NHL and College Football editor at Sports Betting Dime, where he specializes in betting odds and data-driven analysis. Brady has over 10 years experience working in sports media, with work published by outlets such as ESPN, CBS Sports, Yahoo! Sports and Fox Sports.
