Upcoming Match-ups

Dodgers vs Diamondbacks Odds, Predictions & Starting Pitchers (May 22)

Ethan Stone

by Ethan Stone in MLB Baseball

Updated May 22, 2024 · 2:12 PM PDT

Dodgers vs. Diamondbacks
May 21, 2024; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) slides into second base for a stolen base against Arizona Diamondbacks shortstop Kevin Newman (18) at Dodger Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports
  • Arizona visits Los Angeles looking to take a series win over the Dodgers Wednesday night
  • Arizona is in 3rd place in the NL West while the Dodgers sit atop the NL West with a division-leading 33 wins
  • See the Los Angeles Dodgers vs Arizona Diamondbacks odds, predictions, and starting pitchers on May 22

The Los Angeles Dodgers host the Arizona Diamondbacks for the third and final game in their series. The Dodgers took the first game on Monday before a 3-run blast by Arizona’s Joc Pederson gave the Diamondbacks the series-equalizing win on Tuesday.

A win on Wednesday would give the Diamondbacks their best series win of the season while the Dodgers look to avoid their third home series loss of the season.

First pitch for Wednesday’s game is set for 7:10 pm PT/10:10 pm ET from Dodgers Stadium in Los Angeles.

Los Angeles Dodgers vs. Arizona Diamondbacks Odds

Team Moneyline Runline Total
Arizona Diamondbacks (Nelson) +220 +2.5 (-140) O 8.5 (-105)
Los Angeles Dodgers (Glasnow) -275 -2.5 (+105) U 8.5 (-115)

Partially because of the pitching matchup set for Wednesday night and partially because the Dodgers are at home, the run line for this matchup is skewed heavily in favor of Los Angeles (-2.5). The Dodgers sit at -275 to win outright, but the Diamondbacks are favorites to keep the game within a pair of runs (-140) per Fanatics.


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Odds via Fanatics Sportsbook May 22. Check out our Fanatics promo code for more details.

The over/under for Wednesday’s matchup is set at 8.5, which is well under the run totals for Game 1 (6-4) and Game 2 (7-3). It’s worth noting that Arizona is 23-24-2 over/under this season and 8-5 O/U as an away underdog this season. The Dodgers have hit the over 54% of the time (27-23-1) this season and 18-8-1 (69.2%) as the home favorite.

Diamondbacks vs Dodgers Pitching Matchup

Ryne Nelson
Tyler Glasnow
2-3 Record 6-2
7.06 ERA 2.90
5.17 xERA 2.56
1.88 WHIP 0.90
16.3% SO% 33.8%

Here’s the bottom line: the Dodgers have the significant advantage in the pitching matchup Wednesday night.

Glasnow is the top strikeout pitcher in the majors with 81 Ks so far this season, but it’s worth noting that he faces off against a Diamondbacks squad that has been able to avoid striking out at a high clip this year. Regardless, Glasnow has 4 times as many strikeouts on the season compared to Ryne Nelson in twice as many innings pitched.

Nelson has started 7 games for the Diamondbacks this season and sits at a 2-3 record with a 7.06 ERA. He’s allowed 48 hits and 24 runs in 29.1 innings compared to 40 hits allowed and 20 runs in 62 innings for Glasnow.

To reiterate: Glasnow is a strikeout machine. He’s thrown at least 8 strikeouts in each of his last 8 appearances and is the only pitcher in the majors to have thrown 80 strikeouts already this season. 2nd place is Chicago’s Garrett Crochet with 74.

Diamondbacks vs Dodgers Prediction (May 22)

The Dodgers have one of the best batting lineups in the majors while the Diamondbacks have performed slightly better than average. At the same time the Dodgers are going up a weaker pitcher in Nelson and a Diamondbacks bullpen that has really, really struggled this season. And in case that’s not enough of a reason to bet on the Dodgers to win big, Los Angeles is 19-9 as the home team and 12-5 following losses.

Folks, there’s a real chance the Dodgers hit the over by themselves here. Either way, I wouldn’t expect this one to be very close.

LAD vs ARI pick: Dodgers -2.5 (+105), Over 8.5 (-115)

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