Reds vs Cardinals Odds, Lines & Spread (Sep. 17)

By Robert Duff in MLB Baseball
Updated: February 20, 2025 at 11:54 am ESTPublished:

- The St Louis Cardinals are -250 home favorites over the Cincinnati Reds in the Reds vs Cardinals Odds for Saturday, September 17
- The Cardinals are 7-3 SU and 5-5 ATR in the past 10 games against the Reds played at St Louis
- See the Reds vs Cardinals picks, odds, and best bets, below
The St Louis Cardinals (85-60, 49-26 home) are atop the National League Central, while the Cincinnati Reds (57-87, 28-44 away) are near the bottom of the division. There are 26.5 games separating them in the standings.
However, on the diamond, not as much has separated the Cardinals from the Reds this season.
The Reds are 2-2 straight up in the past four against the Cardinals. In 16 meetings with Cincinnati in 2022, St Louis has emerged the winner 10 times.
Regardless, it’s the first-place Cardinals who are getting the love from the oddsmakers in this games. St Louis is a -250 home favorite. The Cardinals are 86-44 against the runline this season. That’s fourth-best in MLB.
Reds vs Cardinals Odds
Team | Moneyline | Runline | Total |
---|---|---|---|
Cincinnati Reds | -205 | +1.5 (+100) | O 8.5 (-105) |
St Louis Cardinals | +250 | -1.5 (-20) | U 8.5 (-115) |
Odds as of September 17 at Caesars Sportsbook. Get Caesars Sportsbook bonus code.
At moneyline odds of -250, the Cardinals have an implied probability of victory of 71.43% in the MLB betting line. A successful $10 wager on St Louis would create a payout of $14.00.

The MLB lineups will be set for the first pitch at Busch Stadium at 1:10 pm ET on Saturday, September 17 in what is the first game of a day-night doubleheader. The weather forecast is calling for mostly sunny skies with 3 mph wind and a temperature of 89 degrees.
MLB betting trends are showing the Cardinals with a betting line of +900 to win the NL flag in the MLB pennant odds. In the World Series odds, the Cardinals are at +2000.
Reds vs Cardinals Probable Pitchers
After a 1-10 start to the season, Reds left-hander Mike Minor has won three of his last four decisions. All three wins have come on the road. Minor is 4-3 away this season, and 0-8 at home.
Mike Minor Double Play‼️ pic.twitter.com/Uzw9K6QR2U
— Votto De La Cruz (@EvilJoeyVotto) September 8, 2022
The lefty is in the bottom 4% of MLB pitchers in wOBA (.380). He’s tied for eighth in the NL in home runs allowed (23).
Against the Cardinals this season Minor is 0-1 with a 7.27 ERA in two starts. Over his career, he’s 2-5 with a 6.12 ERA in 11 appearances, including nine starts. He’s 1-2 with a 6.11 ERA at Busch Stadium.
Minor vs Hudson Stats
4-11 | Record | 7-7 |
5.78 | ERA | 4.43 |
4.55 | xERA | 5.10 |
1.58 | WHIP | 1.42 |
2.14 | SO/W Ratio | 1.29 |
Cardinals right-hander Dakota Hudson rates among the bottom 2% of MLB pitchers in strikeout percentage (13.5). He’s in the bottom 3% in Max EV (116.9) and the bottom 5% in xBA (.277). Hudson is tied for second in the NL in bases on balls issued (56).
In tomorrow’s double-header, RHP Dakota Hudson will start game 1, with LHP Jose Quintana getting game 2, Katie Woo reports.
In three AAA starts, Hudson put up a 1.71 ERA, 2.99 FIP, 3.43 BB/9 and 8.14 K/9. #STLCards pic.twitter.com/aRAplXFFne
— Sports Hub STL (@SportsHubSTL) September 16, 2022
Since August 1, Hudson is 1-3 over nine starts. He was demoted to Triple-A Memphis last week. However, Hudson will be rejoining the Cardinals as the 29th player for today’s twin bill.
In three starts against the Reds this season, he’s 1-2 with a 5.40 ERA. Over 11 career appearances facing Cincinnati, including 10 starts, Hudson is 6-2 with a 3.45 ERA.
Batting Average vs Starting Pitchers
Cardinals Batters | Batting Average vs Minor | Reds Batters | Batting Average vs Hudson |
---|---|---|---|
Nolan Arenado | .333 | Kyle Farmer | .375 |
Paul DeJong | .250 | Jake Fraley | .667 |
Corey Dickerson | .250 | TJ Friedl | .400 |
Paul Goldschmidt | .600 | Jonathan India | 1.000 |
Tyler O’Neill | .600 | Alejo Lopez | .667 |
Albert Pujols | .261 | Matt Reynolds | .667 |
Paul Goldschmidt of the Cardinals, the odds-on -2200 chalk for the NL in the MLB MVP odds, is 9-for-15 (.600) with three homers and five RBI when batting against Minor. Nolan Arenado, the +3500 second betting choice in the NL MVP betting market, is 5-for-15 (.333) with two homers and five RBI. Tyler O’Neill is 6-for-10 (.600) with three homers and five RBI.
Most HR, NL hitters, since Aug. 10:
Albert Pujols 12
Mookie Betts 9
Paul Goldschmidt 9Did I really just type that?
— Jayson Stark (@jaysonst) September 17, 2022
Cincinnati’s Jonathan India is 2-for-2 (1.000) when facing Hudson. Jake Fraley, Matt Reynolds and Alejo Lopez are all 2-for-3 (.667). TJ Friedl is 2-for-5 (.400) with two RBI. Austin Romine has a home and two RBI.
Reds vs Cardinals Prediction
Hudson has allowed 11 earned runs over his past 16 MLB innings for a 6.19 ERA. There’s been an average of 13.5 runs scored over his past four starts. Minor’s last four trips to the mound have seen 9.8 runs per game cross the plate. He’s allowed 22 earned runs through his past six starts.
ALBERT PUJOLS HAS DONE IT AGAIN!! 698!! HE IS TWO HOME RUNS AWAY!!
https://t.co/FlsAbA9OtR— Jared Carrabis (@Jared_Carrabis) September 17, 2022
This game is screaming for an over wager.
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Pick: Over 8.5 (-105)

Sports Writer
An industry veteran, Bob literally taught the course on the history of sports at Elder College. He has worked as a Sports Columnist for Postmedia, appeared as a guest on several radio stations, was the Vice President of the Society For International Hockey Research in Ontario, and written 25 books.