March Madness Odds for All 2024 First Round Games – Spreads, Totals, Moneyline Odds for Round of 64

• The First Four and 28 the first-round matchups are set for the 2024 NCAA Tournament
• Colorado State vs Virginia headlines the First Four matchups on Tuesday, March 19
• Below, see the opening March Madness first round odds for all available games

The 2024 March Madness bracket is set and odds have been released for all the First Four and first round matchups.

The table below lists the odds for all games that are currently set, including the First Four on Tuesday and Wednesday (odds are only available for 28 of 32 first-round matchups as the remaining four won’t be set until the First Four games conclude).

The games below are listed in chronological order (as far as the schedule is known at 7:00 pm ET on Sunday).

March Madness First Round Odds

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Defending Champion UConn the Biggest First Round Favorite

The defending national champions from UConn – the #1 seed in the East –  are the biggest favorites in the round of 64, laying 26.5 points against #16 Stetson. The only other spread that’s north of 20 at the moment is #1 Houston laying 22 against #16 Longwood in the South Region.

Of course, two 1-vs-16 matchups are yet to bet set: #1 North Carolina will face the winner of Howard vs Wagner, while #1 Purdue will face the winner of Montana State vs Grambling.

UConn is also the outright favorite in the latest March Madness championship odds at +479. Houston is second-favorite at +629, while Purdue (which lost in the first round as a #1 seed just last season) is third at +729.

Houston was the top-rated team at KenPom for most of the season, but a blowout loss to Iowa State (69-41) in the Big 12 title game allowed UConn to sneak into the top spot in KP’s efficiency ratings. UConn finished last season as the top team at KenPom, as well, but was only #4 when the 2023 NCAA Tournament commenced.

Two Worse Seeds Favored in First-Round Matchups

Excluding the 8-vs-9 games, the opening March Madness first-round odds see a couple worse seeds favored in their matchups. In the West region, #10 Nevada is a 1.5-point favorite over #10 Dayton.

Also in the West, #11 New Mexico is 1.5-point chalk over #6 Clemson.

Colorado State and Colorado Both Favored in First Four

Both the Colorado State Rams and Colorado Buffaloes were relegated to the First Round, where they will face Virginia and Boise State, respectively.

The Rams have opened as 1.5-point favorites over Virginia and -125 on the moneyline.

The Buffs are two-point chalk over Boise State, which has never won an NCAA Tournament game (0-for-9).