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Giants vs 49ers Props – Best Player Props to Bet for Thursday Night Football

John Perrotto

by John Perrotto in NFL Football

Updated Sep 21, 2023 · 11:57 AM PDT

San Francisco 49ers running back Christian McCaffrey (23) gets by Los Angeles Rams safety John Johnson III (43) for a touchdown
Sep 17, 2023; Inglewood, California, USA; San Francisco 49ers running back Christian McCaffrey (23) gets by Los Angeles Rams safety John Johnson III (43) for a touchdown in the first quarter at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-USA TODAY Sports
  • The 49ers host the Giants to start NFL Week 3 on Thursday Night Football and we have our top Giants vs 49ers props here
  • 49ers running back Christian McCaffrey’s rushing yardage prop over/under is 78.5
  • A look at various Giants vs 49ers player props can be found below with our top TNF prop picks

Christian McCaffrey and the San Francisco 49ers host Daniel Jones and the New York Giants on Thursday Night Football at 8:15 p.m. ET at Levi’s Stadium in Santa Clara, Calif. McCaffrey will feature in our Giants vs 49ers props to target for TNF. See all of our top TNF props here.

McCaffrey has rushed for an NFL-leading 268 yards in helping the 49ers to a 2-0 start, including defeating the Los Angeles Rams 30-23 last Sunday. Daniel Jones helped rally the Giants from a 21-point deficit in the third quarter last Sunday to beat the Arizona Cardinals 31-28 and even their record at 1-1. The odds say Jones won’t throw for more than one touchdown though as his TD prop is juiced to under 1.5 at -234 odds.

Giants vs 49ers Player Props

Passer Completions Passing Yards Passing TDs
Daniel Jones (NYG) 19.5 (O -135 | U +105) 215.5 (O -117 | U -117) 1.5 (O +165 | U -234)
Brock Purdy (SF) 20.5 (O +110 | U -140) 227.5 (O -115) | U -119) 1.5 (O -142 | U -104)
Rusher Rushing Attempts Rushing Yards Rushing + Receiving Yards
Daniel Jones (NYG) OFF 37.5 (O -129 | U -106) OFF
Matt Breida (NYG) OFF 32.5 (O -113) | U -121) 48.5 (O -113 | U -121)
Christian McCaffrey (SF) 17.5 (O +114 | U -145) 78.5 (O -135) | U -101) 113.5 (O -119 | U -115)
Elijah Mitchell (SF) OFF 27.5 (O +100) | U -137) OFF
Receiver Receptions Receiving Yards Longest Reception
Darren Waller (NYG) 4.5 (O +102 | U -139) 46.5 (O -119 | U -115) 18.5 (O -120 | U -110)
Darius Slayton (NYG) 2.5 (O -151 | U +110) 33.5 (O -125 | U -109) 17.5 (O -120 | U -110)
Isaiah Hodgins (NYG) 2.5 (O -148 | U +108) 32.5 (O -115 | U -119) OFF
Parris Campbell (NYG) 2.5 (O -169 | U +123) 27.5 (O -117 | U -117) 15.5 (O -105 | U -125)
Matt Breida (NYG) 2.5 (O +129 | U -179) 12.5 (O -113 | U -121) 8.5 (O -125 | U -105)
Deebo Samuel (SF) 4.5 (O -123 | U -111) 52.5 (O -135 | U -101) 21.5 (O -110 | U -120)
George Kittle (SF) 3.5 (O -154 | U +112) 42.5 (O -119 | U -115) 18.5 (O -120 | U -110)
Christian McCaffrey (SF) 3.5 (O -169 | U +123) 29.5 (O -131 | U -104) 13.5 (O -115 | U -115)

The over/under for McCaffrey’s rushing yardage is 78.5 and the number is 113.5 for his combined rushing and receiving yards. With Saquon Barkley out with an ankle injury, Jones has a 37.5 rushing yards total juiced to the over as he may be called upon to run more and an over/under of 215.5 yards passing.

The 49ers are 10-point favorites and the over/under is 44 points in the NFL odds. As big favorites, it implies that San Fran should put up plenty of points and therefore we’ve targeted two of our three TNF prop picks on 49ers’ players.

Odds as of September 21st at Caesars Sportsbook and DraftKings Sportsbook. Claim one of the top football betting promo codes to make the most of your Giants vs 49ers prop bets tonight!

Giants vs 49ers Props #1: Deebo Samuel Receptions

Deebo Samuel leads the 49ers with 16 targets through two games. That is two more than fellow wide receiver Brandon Aiyuk. Aiyuk has been slowed by a sore shoulder this week and his availability will be a game-time decision.

Thus, it seems logical to think quarterback Brock Purdy will often look in Samuel’s direction. Samuel has 11 receptions for 118 yards so far this season.

Samuel had five catches in the season-opening win over the Pittsburgh Steelers then six last week against the Rams when he finished with 101 combined rushing and receiving yards. It was the first time Samuel cracked trip digits since Week 4 of last season, when he was admittedly out of shape, after doing so eight times in 2021.

Look to the trend of Samuel getting the ball more often to continue Thursday night for your Giants vs 49ers picks.

  • Giants vs 49ers Prop Picks: Deebo Samuel Over 4.5 Receptions -123 (1 unit)

Giants vs 49er Props #2: Matt Breida Rushing Yards

Journeyman Matt Breida figures to get the bulk of the carries for the Giants with Barkley sidelined. Barkley has accounted for 29 of his team’s 33 rushing attempts by running backs this season with Breida getting three and Gary Brightwell one.

Breida has been productive in his limited number of rushes with 14 yards and a touchdown.

Since 2020, Breida has just 142 carries in 40 games and started just twice. However, he did crack 100 yards rushing five times combined in the 2018 and 2019 seasons while playing for the 49ers.

Yards will be hard to come by against the 49ers, who are third in the NFL against the run. Yet with the rushing yards bar set at just 32.5, it is a number Breida can hurdle in the Giants vs 49ers props.

  • Giants vs 49ers Prop Picks: Matt Breida Over 32.5 Rushing Yards -113 (1 unit)

Giants vs 49ers Touchdown Scorer Props

Player Odds to Score 1st TD Odds to Score Any TD
Christian McCaffrey (SF) +265 -220
Deebo Samuel (SF) +500 +108
George Kittle (SF) +675 +170
Daniel Jones (NYG) +850 +215
Matt Breida (NYG) +900 +215
Darren Waller (NYG) +1000 +205
Elijah Mitchell (SF) +1100 +238
Gary Brightwell (NYG) +1200 +375
Darius Slayton (NYG) +1300 +400
Isaiah Hodgins (NYG) +1400 +400

McCaffrey is clearly the most favored player to score a TD on TNF at odds of -220 in the NFL player props. Next up is Deebo Samuel with TNF prop odds of +108 for an anytime touchdown.

Giants vs 49ers Props #3: Christian McCaffrey Anytime TD

McCaffrey scoring a touchdown seems to be a given. He has crossed the goal line in 11 straight games, including the playoffs, dating to last season, and his NFL MVP odds of +2000 are the best among non-quarterbacks.

McCaffrey’s scoring chances are also aided by the fact that he remains one of the few true three-down running backs in the NFL. He has been on the field for 92% of the 49ers’ offensive snaps in 2023.

The Giants are last in the league in scoring defense, making this a great matchup for McCaffrey. Even though the odds won’t provide a big payout if he reaches the end zone, he should be an easy cash for these TNF props.

  • Giants vs 49ers Prop Picks: Christian McCaffrey anytime touchdown scorer -220 (1 unit)

TNF Prop Bet Season Record: 1-5 (-4.9 units)

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