Kansas City Chiefs vs Arizona Cardinals Odds, Lines, and Picks

• The Kansas City Chiefs are 6-point road favorites over the Arizona Cardinals in an NFL game scheduled for Sunday, September 11
• Kansas City is 4-1 SU in the last five games against Arizona.Chiefs QB Patrick Mahomes is 4-0 SU and 3-1 ATS in four NFL season openers
• Get the odds and our Kansas City Chiefs vs Arizona Cardinals picks below

Old friends will be reunited when the Kansas City Chiefs open the NFL season at Arizona against the Cardinals and we have the best Chiefs vs Cardinals picks for the game here.

Back in his NCAA days, Chiefs quarterback Patrick Mahomes played at Texas Tech. His college football coach with the Red Raiders was Kliff Kingsbury, currently the head coach of the Cardinals.

Kickoff at State Farm Stadium is set for 4:25 pm ET. The weather forecast is calling for clear skies, 4 mph wind and a temperature of 97 degrees. CBS is carrying the broadcast, but it can also be streamed via fuboTV. In Canada, the game is available for viewing through DAZN.

Chiefs vs Cardinals NFL Week 1 Odds

Odds as of September 10 at Barstool Sportsbook. See the available Barstool Sportsbook promo code for the NFL here

Oddsmakers are liking the student to school the mentor. It’s the Chiefs who are 6-point road favorites. Kansas City has won seven straight season openers. The Chiefs haven’t lost a Week 1 game on the road since 2009. The total is set at 53.

Chiefs vs Cardinals NFL Betting Trends

In order to beat the Chiefs, Arizona must overcome the Week 1 perfection of Mahomes. Since he took over as Kansas City QB1 in 2018, the Chiefs are 4-0 straight up and 3-1 against the spread.

The Chiefs opened as the 3.5-point chalk over the Cardinals and the line has grown to 6 points, displaying significant action in the NFL line movement. At 53 points, this game is also showing the highest total of any Week 1 contest.

Ready to put on a show 🔥 pic.twitter.com/HLwFj3YNGA

— Arizona Cardinals (@AZCardinals) September 9, 2022

In NFL public betting splits, the people are backing Kansas City. Spread wagering is showing 76% of handle and 67% of bets are on the Chiefs. In moneyline wagering, 71% of handle and 67% of bets are supporting KC. The over is getting the action on the total. There’s 68% of handle and 77% of bets supporting the teams going over 53 points.

Both Kansas City (4th) and Arizona (10th) were top-10 passing teams in the NFL last season.

In Week 1, Mahomes Is The Man

In college, Kingsbury got to gameplan to take advantage of the incredible skills of Mahomes. For the first time as a coach, he must come up with a method to put a governor on those unique talents.

Good luck with that, Kliff. Mahomes opened as the betting favorite in the NFL MVP odds.

.@KliffKingsbury was @PatrickMahomes' head coach at Texas Tech during the QB’s entire college career and on Sunday, the two will meet again on an NFL field. Only this time, it’s on opposing sidelines. pic.twitter.com/g73nV8Ze8A

— NFL (@NFL) September 9, 2022

As a Week 1 NFL starter, Mahomes is 4-0 straight up and 3-1 against the spread. He has thrown for 13 TDs, and never fewer than three in a game. That’s a good stat to know, because the total on Mahomes TD passes in the Chiefs vs Cardinals player props is 2.5. You can get odds of +132 on that wager, so what are you waiting for?

Both Teams Missing Key Pieces

This will be the first time that Mahomes will play a game without his #1 deep threat. Wideout Tyreek Hill, scorer of nine TDs last season, was dealt to Miami in the offseason.

Arizona is also without the club’s top receiver. DeAndre Hopkins is sitting out the first of a four-game NFL suspension for a PED violation.

Here’s the final injury report for the Chiefs and Cardinals heading into Sunday’s game. pic.twitter.com/FiajLAREug

— Matt McMullen (@KCChiefs_Matt) September 9, 2022

On the injury front, Cardinals WR Rondale Moore (hamstring) is out. Tight end Zac Ertz (calf) and LG Justin Pugh (neck) are questionable. On defense, LDE JJ Watt (calf) and LCB Byron Murphy Jr (illness) are questionable. Murphy’s backup Trayvon Mullen (toe) is out.

The Chiefs report no injuries to starters.

Caesars Offering Mahomes Odds Boost

Caesars Sportsbook is offering a Week 1 super boost with a maximum bet of $100. Bet on a parlay of Mahomes to go over 2.5 TD passes and 299.5 yards passing in your Chiefs vs Cardinals prop bets and get odds of +275.

#ChiefsKingdom Patrick Mahomes is an escape artist. #AZCardinals look to contain him in their first matchup of the season. @DariusJButler shows how deadly Mahomes can be to a defense through his 2nd reaction plays. #NFL@gregcosell | @DariusJButler | @PlaybooKFoley pic.twitter.com/6eEFoX4ntt

— NFL Matchup on ESPN (@NFLMatchup) September 9, 2022

A winning wager at the maximum amount of $100 offers an implied probability of success of  26.67% and a payout of $375.

Chiefs vs Cardinals Prediction

Kansas City is 11-2 SU in the month of September with Mahomes at QB. He’s passed for 4,244 yards in those games, with 328 completions. That works out to 12.9 yards per completion. There’s been 41 TD passes against only three interceptions.

Patrick Mahomes Career Stats in the Month of September…

13 games

328 comp.
481 att.
68.2 % Comp %
4,244 pass yards
12.9 Yards/Comp.
8.8 Yards/Att.
41 Pass TD's
3 INT's

47 rush att.
256 rush yards
5.4 Yards/Att.

The Chiefs and Patrick Mahomes are 11-2 in September Games! pic.twitter.com/BjNjMCvVrw

— Chiefs Focus: Behind the Numbers 📊 (@CFStatistics) September 9, 2022

The departure of Hill hasn’t hurt the Chiefs as much as it’s given them motivation and a rallying cry to show those critics who are writing them off how wrong they are in that assessment.

Unfortunately for the injury-weakened Cardinals, they’ll get the first taste of KC vengeance.

Pick: Kansas City Chiefs -6 (-113); 1 unit