NFL Week 10 Injury Report: Updates on St Brown, Walker III, Ferguson

• Kenneth Walker is a late scratch after suffering an injury in practice
• Dallas and Minnesota will be without their top tight ends
• Continue reading for a look at the Week 10 injury reports

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Week 10 brings a range of significant injuries with potential implications for team plans and betting markets. The players below are the notable names to monitor; their listed practice participation and game designations are shown separately, since a limited or full practice does not by itself determine availability.

NFL Week 10 Injury Report: Star Player Updates

Quarterback absences can have the greatest effect on a team’s outlook, while receiver and defensive absences more often change matchup considerations and player-prop expectations. The listed designations are a starting point, not a substitute for checking final active lists and current odds before placing a wager.

Jake Ferguson, TE, Dallas Cowboys

Ferguson is out with a knee injury after missing practice. His absence removes a receiving option from Dallas and may shift opportunities among the other tight ends and pass-catchers.

Ferguson’s absence vacates an indispensable 19.8% target share and leaves a massive void in high-leverage scoring territory, where he leads the Cowboys with six red-zone targets this season. With Dallas facing a stout 49ers defense that aggressively clamps down on perimeter boundary wideouts, Prescott will be forced to funnel quick-release looks into vacated intermediate zones. Backup tight ends Luke Schoonmaker and Brevyn Spann-Ford should absorb inline snap volume, but the true beneficiary is third receiver Ryan Flournoy and the running back check-down market. Bettors should look to back modest reception overs for the complementary pass-catchers while shaving Dallas’ expected red-zone touchdown conversion rate.

Amon-Ra St. Brown, WR, Detroit Lions

St. Brown is questionable with a rib injury after a limited practice. If he is active, the designation alone does not establish that he will have his usual workload; if inactive, attention may shift to Detroit’s remaining receiving options.

St. Brown serves as the undisputed fulcrum of Detroit’s aerial attack, demanding a 28.6% target share and an 82% route participation rate over the middle of the field. A rib ailment severely threatens a receiver whose calling card is absorbing punishing hits in traffic on crossing routes and contested third-down slants. If St. Brown is forced to play on a pitch count or sit out entirely in Munich against New England’s man-coverage scheme, Jared Goff will funnel looks toward Jameson Williams on perimeter shots and Sam LaPorta over the seams. Furthermore, Jahmyr Gibbs’ receiving props gain immediate upside on schemed angle routes and screen designs out of the backfield.

Marvin Harrison Jr, WR, Houston Texans

Harrison is out with a hamstring injury after not practicing. His unavailability affects Houston’s receiving options and can alter how targets are distributed among the remaining pass-catchers.

Harrison’s absence strips Houston of a premier boundary field-stretcher. This shifts defensive coverage shells drastically, allowing the Cleveland Browns to roll safety help directly toward Nico Collins and crowd the line of scrimmage against David Montgomery. While Collins will see an elite target share exceeding 30%, his efficiency metrics face resistance against Cleveland’s aggressive press-man coverage. For prop bettors, targeting the Under on C.J. Stroud’s gross passing yards and looking toward Dalton Schultz on underneath checkdowns represent the sharpest strategic angles.

Kyler Murray, QB, Minnesota Vikings

Murray is out with a hamstring injury and did not practice. The Vikings will turn to Kirk Cousins whom they acquired at the trade deadline.

Losing Murray removes Minnesota’s ability to extend plays outside the pocket and completely paralyzes an offense that relies on his off-script mobility to mitigate offensive line protection issues. With key weapons like T.J. Hockenson also ruled out, the Vikings face a Green Bay defense that thrives at collapsing standard pockets without needing to blitz. The betting market responded by knocking Minnesota down to home underdogs and slashing the game total to 42 points. Bettors should lean into game-script Unders, expect Minnesota to adopt a slow-paced, run-centric plan in Cousins’ first start back for the Vikings, and prepare to fade Cousins’ passing totals across the board.

A.J. Brown, WR, New England Patriots

Brown is questionable with an ankle injury after a limited practice. His final availability and expected workload matter most for New England’s passing-game outlook and related receiving props.

Brown functions as Drake Maye’s premier perimeter alpha, commanding an elite 31.2% first-read target share and generating 2.84 yards per route run against single coverage. Playing through an ankle and knee sprain in an international setting against Detroit’s aggressive secondary poses major re-injury risk and could compromise his sudden change-of-direction ability on boundary comeback routes. If Brown is active but limited as a decoy, Maye’s downfield efficiency drops sharply, forcing offensive coordinator Josh McDaniels to lean into the ground game and tight end dump-offs. If Brown is ruled inactive, New England becomes an immediate fade against the spread, while Hunter Henry’s reception props become priority over targets.

Garrett Wilson, WR, New York Jets

Wilson is questionable with a concussion despite logging a full practice. The designation remains relevant, so monitor the final clearance and active roster before considering Jets passing props.

While a full practice on Friday signals that Wilson has progressed to the final phase of the NFL concussion protocol, independent neurological clearance is mandatory before he can take the field against Buffalo. Wilson accounts for 30.5% of the Jets’ target volume and represents their sole reliable separator against split-safety zone coverages. If Wilson is held out, the Jets’ passing ceiling collapses entirely, leaving Adonai Mitchell and Omar Cooper. A Wilson absence would make the Under on the Jets’ team total an elite wager while simultaneously pushing significant checkdown volume toward Breece Hall and Braelon Allen out of the backfield.

Mike Evans, WR, San Francisco 49ers

Evans is out with an Achilles injury after not practicing.

Evans being ruled out leaves San Francisco without their premier perimeter red-zone target against the Dallas Cowboys. While Deebo Samuel Sr. was cleared of his injury designation, Evans’ absence removes an imposing 6-foot-5 boundary presence that accounts for over 40% of the 49ers’ end-zone targets this season. Against a Dallas defense that deploys single-high safety looks and dares teams to beat them deep, Brock Purdy will pivot toward quick-hitting intermediate concepts featuring Samuel and George Kittle over the middle. For prop bettors, Evans’ absence provides a massive floor boost for Kittle’s anytime touchdown odds and guarantees an expanded carry and target workload for Christian McCaffrey in scoring territory.