Opening NFL Week 5 Odds & Byes – Week 5 Spreads, Totals, Moneylines for All Games
By Sascha Paruk in NFL News
Published:
The 2026 NFL season moves quickly into its fifth week of action, and DraftKings has already posted opening lines across the slate. Week 5 brings several heavyweight non-conference battles, classic division rivalries, and pivotal early-season measuring sticks.
The action begins with an NFC Thursday night clash in Arlington between the Dallas Cowboys (2-2) and Tampa Bay Buccaneers (0-4) and extends through an action-packed Sunday before wrapping up with Monday Night Football in Inglewood when the Buffalo Bills (3-1) visit the Los Angeles Rams (2-2).
Below is the Week 5 odds board, including available opening lines and pending matchups. The Kansas City Chiefs and Carolina Panthers are on bye. Fans won’t get another 16-game week until Week 15.
NFL Week 5 Odds
Odds as of Oct 4 at DraftKings. Claim the best NFL betting promos ahead of Week 5.
Opening Buccaneers vs Cowboys Odds
Week 5 action kicks off at AT&T Stadium on Thursday night, where the Dallas Cowboys (2-2, 3-1 ATS, 4-0 O/U) are 10-point home favorites over the Tampa Bay Buccaneers (0-4, 0-4 ATS, 2-2 O/U) in the opening TNF odds. The Week 5 NFL odds install Dallas as a massive -625 favorite on the moneyline (86.2% implied win probability), with Tampa Bay returning at +455.
The Buccaneers enter desperate to secure their first victory of the 2026 campaign after a 17-7 home loss to Green Bay in Week 4 and face an uphill battle on a short week while remaining without starting quarterback Baker Mayfield for the second consecutive game. Meanwhile, the Cowboys look to get back above .500 after coming up just short in a 23-20 road defeat against Houston.
Opening Eagles vs Jaguars Odds
Sunday’s international action heads across the pond to Tottenham Hotspur Stadium in London, where the Jacksonville Jaguars (3-1, 3-1 ATS, 1-3 O/U) open as 3.5-point favorites over the Philadelphia Eagles (2-2, 0-4 ATS, 3-1 O/U). Jacksonville is -180 on the moneyline (64.3% implied win probability), while Philadelphia comes back as a +150 underdog, with the game total set at 42.5.
The Jaguars enter riding high after grinding out a 16-10 road victory against Cincinnati in Week 4, whereas the Eagles aim to rebound following a 24-20 setback against the Los Angeles Rams, which saw superstar running back Saquon Barkley leave in the first quarter due to injury.
Opening Bears vs Packers Odds
One of the NFL’s most storied rivalries renews at Lambeau Field as the Chicago Bears (3-1, 3-1 ATS, 1-3 O/U) visit Green Bay as 1.5-point road favorites over the Packers (2-2, 1-3 ATS, 2-2 O/U). On the moneyline, Chicago is listed at -118 (54.1% implied win probability) with Green Bay priced at -102 in a near pick’em divisional matchup, alongside an over/under total of 44.5.
Chicago enters following a dominant 20-6 home win over the New York Jets in Week 4, while the Packers look to defend their home turf after picking up an important 17-7 road victory in Tampa Bay. The availability of Chicago QB1 Caleb Williams will be determined over the course of the week, but Chicago is 2-0 in his absence with QB3 Case Keenum and QB2 Tyson Bagent each earning a W.
Opening 49ers vs Seahawks Odds
A crucial NFC West showdown takes center stage at Lumen Field, where the Seattle Seahawks (2-1 SU, 2-1-1 ATS, 1-3 O/U) open as 3-point home favorites over the San Francisco 49ers (3-0 SU, 2-2 ATS, 2-2 O/U). DraftKings has listed Seattle at -155 on the moneyline (60.8% implied win probability), with San Francisco tagged at +130 on the moneyline and the game total set at 46.5. Seattle looks to defend home field in one of the league’s toughest venues, while the 49ers aim to keep their undefeated straight-up record intact against their primary division rival.
Opening Colts vs Steelers Odds
AFC playoff contenders collide at Acrisure Stadium as the Pittsburgh Steelers (2-2 SU, 2-2 ATS, 2-2 O/U) host the Indianapolis Colts (2-2 SU, 3-1 ATS, 2-2 O/U) as 2.5-point home favorites. DraftKings has installed Pittsburgh at -135 on the moneyline (57.4% implied win probability), while Indianapolis returns at +114 as road underdogs, with the total set at 44.5. The Colts arrive with momentum following a commanding 30-13 win over Washington in London, while the Steelers seek to bounce back after a 24-10 loss to Baltimore.
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Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
