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NFL Picks for Week 10 – Best A.I. ATS & O/U Bets

Sascha Paruk

By Sascha Paruk in NFL News

Published:


New England Patriots quarterback Drake Maye standing in the pocket
Nov 2, 2025; Foxborough, Massachusetts, USA; New England Patriots quarterback Drake Maye (10) looks to pass against the Atlanta Falcons during the first half at Gillette Stadium. Mandatory Credit: Eric Canha-Imagn Images
  • I have generated our A.I.’s NFL Week 10 picks (ATS and O/U) for all 14 games
  • The A.I. is having a bad first season, but it’s 8-1 ATS on Patriots games
  • See the A.I. NFL Picks for Week 10 plus the A.I.’s ATS and O/U record for all teams in action

The NFL Week 10 lines have been posted and I have already asked our internal A.I. to generate its ATS and O/U picks for every game.

The A.I. has been rock-solid picking player props, both in the NFL and NBA, but it is having a horrendous season with its ATS picks (60-74) and O/U picks (58-76) in the NFL. That said, it seems to have a much better read on some teams than others, going 8-1 ATS on New England Patriots games, for instance, and a stunning 0-8 O/U on Falcons games and 0-8 ATS on Eagles games.

The table below sets out the A.I.’s NFL picks for Week 10, roughly in chronological order. Under the table, I have added one-click options to tail each bet along with the A.I.’s record for each team in each game this week.

A.I. NFL Picks for Week 10

GameATS PickO/U Pick
LV Raiders vs DEN BroncosBroncos -8.5Under 42.5
ATL Falcons vs IND Colts*Colts -5.5Over 48.5
BAL Ravens vs MIN VikingsRavens -3.5Over 47.5
NE Patriots vs TB BuccaneersPatriots +2.5Over 48.5
JAX Jaguars vs HOU TexansJaguars +1.5Under 38.5
CLE Browns vs NY JetsJets -1.5Under 37.5
NO Saints vs CAR PanthersPanthers -4.5Under 40.5
NY Giants vs CHI BearsBears -3.5Over 48.5
BUF Bills vs MIA DolphinsBills -8.5Over 49.5
ARI Cardinals vs SEA SeahawksSeahawks -6.5Over 44.5
LA Rams vs SF 49ersRams -3.5Over 49.5
DET Lions vs WSH CommandersCommanders +9.0Under 51.5
PIT Steelers vs LA ChargersChargers -3.0Over 44.5
PHI Eagles vs GB PackersPackers -2.5Under 44.5

*Denotes neutral-field game in Berlin, Germany.

Below, I have set out the picks on a game-by-game basis, in the same order they are listed in the table. In each section, I have set out the A.I.’s ATS and O/U record for both teams.

NFL betting odds as of 4:01 pm ET, November 3rd. Bookmark SBD’s guide to find the latest football betting promo codes.

LV Raiders vs DEN Broncos Picks

A.I record:

  • Raiders ATS 3-5
  • Broncos ATS 3-6
  • Raiders O/U 5-3
  • Broncos O/U 6-3

ATL Falcons vs IND Colts Picks

A.I record:

  • Falcons ATS 0-8
  • Colts ATS 7-2
  • Falcons O/U 5-3
  • Colts O/U 3-6

BAL Ravens vs MIN Vikings Picks

A.I record:

  • Ravens ATS 3-5
  • Vikings ATS 2-6
  • Ravens O/U 2-6
  • Vikings O/U 2-6

NE Patriots vs TB Buccaneers Picks

A.I record:

  • Patriots ATS 8-1
  • Buccaneers ATS 5-3
  • Patriots O/U 3-6
  • Buccaneers O/U 3-5

JAX Jaguars vs HOU Texans Picks

A.I record:

  • Jaguars ATS 6-2
  • Texans ATS 4-4
  • Jaguars O/U 2-6
  • Texans O/U 5-3

CLE Browns vs NY Jets Picks

A.I record:

  • Browns ATS 5-3
  • Jets ATS 3-5
  • Browns O/U 5-3
  • Jets O/U 2-6

NO Saints vs CAR Panthers Picks

A.I record:

  • Saints ATS 7-2
  • Panthers ATS 4-5
  • Saints O/U 4-5
  • Panthers O/U 4-5

NY Giants vs CHI Bears Picks

A.I record:

  • Giants ATS 3-6
  • Bears ATS 3-5
  • Giants O/U 2-7
  • Bears O/U 1-7

BUF Bills vs MIA Dolphins Picks

A.I record:

  • Bills ATS 1-6
  • Dolphins ATS 5-4
  • Bills O/U 1-6
  • Dolphins O/U 3-6

ARI Cardinals vs SEA Seahawks Picks

A.I record:

  • Cardinals ATS 3-4
  • Seahawks ATS 3-5
  • Cardinals O/U 3-4
  • Seahawks O/U 4-4

LA Rams vs SF 49ers Picks

A.I record:

  • Rams ATS 5-3
  • 49ers ATS 2-5
  • Rams O/U 4-4
  • 49ers O/U 3-4

DET Lions vs WSH Commanders Picks

A.I record:

  • Lions ATS 4-4
  • Commanders ATS 5-4
  • Lions O/U 3-5
  • Commanders O/U 7-2

PIT Steelers vs LA Chargers Picks

A.I record:

  • Steelers ATS 5-3
  • Chargers ATS 2-6
  • Steelers O/U 2-6
  • Chargers O/U 6-2

PHI Eagles vs GB Packers Picks

A.I record:

  • Eagles ATS 0-8
  • Packers ATS 1-7
  • Eagles O/U 4-4
  • Packers O/U 5-3

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Sascha Paruk
Sascha Paruk

Managing Editor

Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.

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