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Seattle Seahawks vs San Francisco 49ers Odds, Predictions and Picks for Wild Card Weekend

Robert Duff

by Robert Duff in NFL Football

Jan 13, 2023 · 9:01 AM PST

San Francisco 49ers QB Brock Purdy rolls out
Jan 8, 2023; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs the ball against the Arizona Cardinals in the third quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports
  • The San Francisco 49ers are 10-point home favorites over the Seattle Seahawks in their NFC Wild Card Weekend game on Saturday, January 14
  • The Seahawks are 4-4 SU on the road this season
  • San Francisco is 2-0 straight up and against the spread vs Seattle this season and are -475 moneylive favorites in the Seahawks vs 49ers odds

The San Francisco 49ers (13-4, 11-6 ATS) and Seattle Seahawks (9-8, 7-10 ATS) are basically mirror images. San Francisco is 7-1 against the spread in the past eight games. Seattle is 1-7 ATS over the past eight games. It’s San Fran who are heavy favorites on Saturday in the Seahawks vs 49ers odds.

The 49ers have won 10 in a row straight up overall and five in a row SU at home. The Seahawks are 3-5 SU over the last eight games and 1-2 SU through their last three road games.

Oddsmakers are leaning toward the second-seeded 49ers heavily to win this NFC Wild Card Weekend contest in the Seattle vs San Francisco picks. San Francisco is the 10-point home chalk. Seattle is the #7 seed and seven seeds are 0-4 SU and 1-3 ATS in the NFL Playoffs the past two years in Wild Card betting trends.

Seahawks vs 49ers Odds

Team Spread Total Moneyline
Seattle Seahawks +10 (-110) O 42 (-110) +380
San Francisco 49ers -10 (-110) U 42 (-110) -475

Odds as of January 13 at Caesars Sportsbook. See the available Caesars Sportsbook promo code for the NFL here

The 49ers were set as 6.5-point home favorites when the NFL Wild Card Weekend opening lines were unveiled.

Seattle vs San Francisco Game Info

Kickoff at Levi’s Stadium is set for 4:30 pm ET on Saturday, January 14. The weather forecast is calling for rain, 19 mph wind and a temperature of 57 degrees. The game is airing on FOX Sports in the USA and on DAZN in Canada.

Seahawks vs 49ers NFL Betting Trends

In the NFL public betting trends, the people are right there with the oddsmakers in backing the 49ers in a big way. San Francisco is getting 75% of handle and 68% of bets in spread splits. In moneyline splits, the public is going with the Niners with 86% of handle and 85% of bets.

As far as the total of 42 points, the public splits are supporting the over. There’s 54% of handle and 62% of bets going that route. Five of San Francisco’s last six games went over. However, four of Seattle’s last five games have gone under.

San Francisco is the third betting choice in the Super Bowl odds at +450. Seattle is in the 11th spot at odds of +5000.

McCaffrey Powering 49ers Surge

In 11 games with San Francisco, RB Christian McCaffrey has rushed for 746 yards and six TDs. He’s also caught 52 passes for 464 yards and four TDs. In McCaffrey’s 10 starts, San Francisco is 10-0.

The other pleasant surprise is the play of QB Brock Purdy. Since taking over following an injury to Jimmy Garoppolo, Purdy is 5-0. He’s thrown for 1,374 yards and 13 touchdowns this season. He may even be making a late run in the NFL OROY balloting.

Can Seahawks Get Run Game Going?

Seattle QB Geno Smith set a franchise record, passing for 4,282 yards. But the Seahawks will require a balanced attack. That’ll be tough to achieve against San Francisco’s run defense. The Niners are limiting teams to an NFL-low 3.4 yards per carry.

In two games against the 49ers, it’s the San Francisco defense dominating this battle. During the 49ers’ 27-7 Week 2 victory, Seattle was held to 14 carries for 36 yards.

More recently, and with NFL OROY favorite Kenneth Walker III firing on all cylinders, Seattle ran for 70 yards on 14 carries. That was during a 21-13 Week 15 victory for San Francisco.

Overall, that works out to 3.78 yards per carry. Walker was 12 carries for 47 yards in that game, or 3.92 yards per carry. Walker’s gone for 100+ yards in three straight games. He’ll be hard-pressed to get to four.

Seattle Hurting at RB with Walker and Dallas Injuries

Another issue with the Seattle run game is that the club is banged up at the position. Both Walker (ankle) and backup DeeJay Dallas (ankle) are hurting, although Walker’s injury designation was removed on Friday. Dallas is listed as questionable but is expected to play. Rashaad Penny is on IR.

On defense, the Seahawks are showing LDE Shelby Harris (knee) as questionable.

There are five 49ers starters who are listed as questionable for this game. McCaffrey (ankle) and left guard Aaron Banks (ankle) are the offensive starters with a questionable designation.

Defensively, both starting DTs – Arik Armstead (foot) and Javon Kinlaw (knee) – are questionable, as is WLB Dre Greenlaw (back).

Seahawks vs 49ers Prediction

The 49ers are 8-2 ATS over their past 10 games. Seattle used to dominate this series and are in fact 15-4 SU in the past 19 meetings. But that was then. This is now.

The 49ers are the dominant team this season. But 10 points is a lot to give in a playoff game. Back Seattle in your Seahawks vs 49ers picks.

  • Pick: Seattle Seahawks +10 (-110)
  • 2022-23 record (0-0 ML, 7-9 ATS, 1-0 O/U)

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