SNF Week 1: Cowboys vs Giants Odds, Picks and Predictions

• The Dallas Cowboys are 2.5-point road favorites on SNF vs the New York Giants
• New York offers undeniable value as a home underdog against a squad riding a massive against-the-spread losing streak
• See below for the Cowboys vs Giants odds, picks and predictions for SNF

It’s a banger between NFC East rivals to kick off Sunday Night Football, as the Dallas Cowboys head to East Rutherford to clash with the New York Giants.

Entering the matchup as road favorites in the NFL odds, the Cowboys are looking to seize early divisional control against a Giants squad embracing its role as the home underdog.

You can catch all the action when the game kicks off on Sunday night at 8:20pm Et, broadcasting live on NBC and Peacock from MetLife Stadium.

Cowboys vs Giants Odds

Odds as of September 12. Click here for a bet365 Sportsbook promo code to bet on NFL games this season.

Dallas enters this matchup as a 2.5-point road favorite on FanDuel, while getting -150 odds on the moneyline at BetMGM to secure the outright victory.

For the G-Men, they’re getting -111 odds and given three points on the spread, with more enticing +140 odds at bet365 to grab an upset win.

You can bet the total on two fronts. Over bettors should bead to bet365, where the line is set at 47.5 points, apying -110 odds. For Under bettors, check out DraftKings, where you get a full point more, to 48.5.

DAL Cowboys vs NY Giants Picks and Predictions

This classic rivalry promises plenty of primetime drama as Dallas relies heavily on veteran quarterback Dak Prescott to command the air raid offense. Meanwhile, New York will look to elite pass rusher Brian Burns to disrupt the pocket and star playmaker Odell Beckham Jr to ignite the home crowd.Dallas has largely dominated the straight-up win column in recent matchups against New York. Over the last eight meetings between these NFC East rivals, the Cowboys boast a commanding 7-1 record.

However, despite this outright success in the rivalry, the Giants have been the far more reliable team for bettors when backing the point spread. New York routinely manages to keep games closer than oddsmakers anticipate, going 3-1 ATS over their last four games against Dallas.

Entering this matchup, both teams are desperate to reverse poor current forms. Dallas has hit a notable rough patch, going just 1-4 straight up over its last five games. Meanwhile, New York has posted a dismal 2-8 record over its last 10 contests. This divisional clash is a prime opportunity to build momentum.

Spread Pick: Giants +3.5 (-127 at Polymarket)

Despite Dallas commanding road favorite status, backing the Giants with the full field-goal-plus-hook cushion is supported by overwhelming situational data:

Cowboys ATS Freefall: Dallas has struggled mightily against market expectations, going 0-5 ATS over its last five games.

Road Favorite Struggles: This issue magnifies when Dallas travels as a favorite, where they have covered just once in their last six attempts (1-5 ATS).

Divisional Value for New York: The Giants have consistently played Dallas tight, covering in three of their last four meetings (3-1 ATS), including an outright 34-17 victory in Week 18. With Malik Nabers leading the perimeter attack and Dallas’ defense experiencing notable road regression, catc

Game Total Pick: Over 48.5 (+108 at Kalshi)

Prediction Markets

O/U Prediction

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Kalshi

Over 48.5

48%

Predict

While 48.5 represents one of the higher totals on the Week 1 board, tactical pacing and recent history point squarely toward a primetime shootout:

Explosive Head-to-Head History: The Over has cashed in three straight matchups between these rivals, including a 77-point thriller in Week 2 of 2025 (40-37 Dallas) and 51 points in Week 18 (34-17 New York). With fast turf conditions and aggressive early-down passing from both offenses, expect this game to clear 49 points with room to spare.

Dallas Road Overs: The Cowboys’ aggressive passing identity and leaky secondary away from home have created a scoring bonanza, with the Over hitting in 100% of Dallas’ last seven road games (7-0).

Giants High-Scoring Profile: New York has consistently engaged in shootouts, with the Over cashing in 80% of their last 10 games (8-2).