NFL Week 10 Odds – Opening Betting Lines & Spreads for All Games

• The Bears host the Panthers on Thursday Night Football to open NFL Week 10
• The Cowboys are the biggest favorite, laying 10 points against the Giants
• A look at all the opening NFL Week 10 odds can be found below with early predictions

One of the more intriguing games in the NFL Week 10 odds features the San Francisco 49ers and the Jacksonville Jaguars. Looking to end a three-game skid following a 5-0 start, the 49ers are in Jacksonville to face the AFC South-leading Jaguars.

Sunday Night Football features the New York Jets as 1.5-point chalk at the Las Vegas Raiders. The Raiders just whipped the New York Giants at home in Week 9. It’s the second straight game against an AFC West opponent for the Jets. They’re facing the Los Angeles Chargers in the Week 9 MNF game.

The Monday Night Football puts two old AFL foes on the field as the Denver Broncos visit the Buffalo Bills. The table below lists the opening NFL Week 10 odds for all 14 games on the schedule.

Opening NFL Week 10 Odds

The NFL odds for Week 10 show the Dallas Cowboys as the biggest favorite. They’re the 10-point home chalk against the Giants. Dallas won 40-0 on the road against the Giants in Week 1. The Giants have trailed by 20+ points in an NFL-high four games this season.

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Odds as of November 5 on the FanDuel app. Bettors who have already claimed a FanDuel signup bonus can click here to see the latest on the upcoming ESPN Bet promo code. 

As far as the smallest spread is concerned, five games are set with teams as 1.5-point picks. The Patriots are a 1.5-point choice at home against the The Indianapolis Colts. Tampa Bay are the 1.5-point home chalk over Tennessee. Detroit is the 1.5-point road pick at the Chargers and the Falcons are a 1.5-road underdogs at Arizona. At Las Vegas, the Jets are a 1.5-point Chois over the Raiders

The Lions and Chargers are also showing the largest over/under at 48.5 points. Meanwhile the lowest total is the 37 points assigned to the Jets vs Raiders contest.

The reigning-champion Kansas City Chiefs continue to lead the Super Bowl odds at +500 after eking out a 21-14 over the Miami Dolphins in Germany. Three teams – Miami, Detroit, and Jacksonville – are tied for the best NFL ATS records heading into Week 10, with all three teams at 6-2 ATS.

Jets vs Raiders Early Odds & Predictions

Does Las Vegas have a New York sweep in them? They drubbed the Giants at home on Sunday.

The Jets enter the Week 9 MNF game a solid 4-2-1 ATS this season. They are 1-1-1 ATS as a road team.

WHAT. A. START.#NYGvsLV | 📺 FOX pic.twitter.com/ooMAcuBUzL

— Las Vegas Raiders (@Raiders) November 5, 2023

Las Vegas is a solid 3-1 ATS at home this season. The Raiders are also 4-3 ATS as the home chalk since the start of the 2021 season.

Pick: Jets -1.5 (-115)

Opening Broncos vs Bills Odds & Predictions

Neither Buffalo (3-5) or Denver (2-5-1) were entering Week 9 as solid ATS picks.

At home, the Bills are 2-2 ATS. Denver is a dreadful 0-2-1 ATS on the road. The Broncos are 0-2-0 as the away underdog.

Buffalo is 7-0 ATS in the last seven games against Denver. The Bills are 4-0 ATS at home against the Broncos. Denver’s most recent win at Buffalo was a 15-14 verdict in 2007.

Pick: Bills -8.5 (-110)

Expected Week 10 Line Movement

As big as the spread opening spread was on the Giants vs Cowboys game, it quickly grew longer. Giants QB1 Daniel Jones left their loss to the Raiders with a knee injury. Backup Tyrod Taylor was placed on IR last week.

Non-contact injury to Daniel Jones, very tough for him… pic.twitter.com/5Zlw7fPV9g

— Alex Wilson (@AlexWilsonESM) November 5, 2023

That leaves rookie QB Tommy DeVito at the helm of the Giants offense. He’s thrown 27 passes in his NFL career. A line that opened at Dallas -10 has already lengthened to Cowboys -14.5.

Pick: Cowboys -14.5 (-110)