Baltimore Ravens vs Buffalo Bills Picks, Odds & Best Bets

• The Buffalo Bills host the Baltimore Ravens in the final game of the NFL Divisional Playoffs on Sunday night
• The Ravens waxed the Bills in the regular season, but Buffalo has yet to lose at home this year
• See the final Buffalo Bills vs Baltimore Ravens odds, expert picks, and best bets for Jan. 19

Two legitimate Super Bowl contenders meet in the AFC Divisional Playoffs on Sunday night as the Baltimore Ravens (13-5, 6-3 away) visit the Buffalo Bills (14-4, 9-0 home) at 6:30 pm ET at Highmark Stadium for the right to face the two-time defending-champion Kansas City Chiefs in the AFC title game next weekend. After the Ravens/Bills odds opened with Buffalo as a slight 1.5-point favorite, the line almost immediately flipped, making Baltimore a slight one-point road favorite, which is where the line still stands as of Sunday afternoon.

Baltimore Ravens vs Buffalo Bills Odds

The Ravens are also -120 moneyline favorites with the Bills coming back as even-money home underdogs. The game total, which opened at 52.5, is now sitting a point lower at 51.5. Overs are just 2-6 so far in the 2025 NFL playoffs.

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Both teams are in good shape, health-wise. The Ravens vs Bills injury reports list just two players on the Baltimore side – Zay Flowers (doubtful, knee) and Deonte Harty (questionable, knee) – while Ray Davis (questionable, concussion) is the only player listed on the Buffalo injury report.

The Ravens enter the Divisional Playoffs as +450 third-favorites in the Super Bowl 59 odds. Buffalo is the next team on the board at +450. Baltimore dominated Buffalo (35-10) when the teams met in Maryland back in Week 4.

Baltimore vs Buffalo Betting Trends

While the Bills are a perfect 9-0 at home straight-up this season, including last week’s 31-7 domination of Denver, that record drops to 6-3 against the spread. Buffalo failed to cover in its wins over Arizona (34-28 as 6.5-point favorites in Week 1), Miami (30-27 as six-point favorites in Week 9), and New England (24-21 as 14-point favorites in Week 14).

Encouragingly for Buffalo fans, last week’s win over the Broncos was one of Buffalo’s best defensive performances of the season. The Bills held Sean Payton’s team to just 224 yards of total offense, 145 through the air and 79 on the ground. They managed to hold Denver scoreless on its final seven possessions (including four punts) despite not forcing a single turnover and Denver taking just three penalties.

The Ravens are 6-3 straight-up on the road and have an identical road ATS record. Baltimore covered the spread in all six of their road victories and failed to cover in each of their three road setbacks. Baltimore won its last three road games during the regular season, taking down the Chargers (30-23), Giants (35-14), and Texans (31-2) in a trio of excellent road performances.

Ravens vs Bills Expert Pick & Best Bet

I have been on the Bills ever since the line swung to make them home underdogs. There are plenty of reasons to get behind the Ravens, and I don’t fault my colleague for including a couple Baltimore players in his Ravens vs Bills same-game parlay, but the Buffalo defense is undoubtedly going to do a better job of stopping the run than it did in Week 4, when the Ravens put up 271 rushing yards during a 35-10 home victory.

With Zay Flowers either out or slowed, the Bills are going to be able to devote more resources to Derrick Henry and Lamar Jackson’s legs. The Buffalo D is also healthier now than it was during the vast majority of the regular season.

BAL vs BUF pick: Bills moneyline (+100)