Minnesota vs Oregon Spread, Prediction & Best Bets (Nov. 14)

• Oregon looks to stay hot in Big Ten play as they host Minnesota on Friday night
• The Golden Gophers play at Oregon for the first time in program history
• Read below for my Minnesota vs Oregon spread, prediction and best bets

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The Minnesota Golden Gophers (6-3, 4-2 in the Big Ten) head west to face the No. 8 Oregon Ducks (8-1, 5-1 in the Big Ten). Autzen Stadium in Eugene hosts a 9 p.m. ET kickoff on Friday, Nov. 14 on a FOX broadcast.

Below, I have made my Minnesota vs Oregon prediction and provided a pair of best bets to follow on Friday night.

Minnesota vs Oregon Spread

The oddsmakers have Oregon as big home favorites for this Big Ten matchup. The Minnesota vs Oregon spread ranges from -24.5 to -26.5 depending on the sportsbook. The total is set between 43.5 and 44.5 points.

Over bettors can get over 43.5 at DraftKings for -118 odds. Under bettors can get under 44.5 on BetRivers for -113 odds.

Oregon bettors can get the Ducks at -24.5 on the spread at ESPN Bet (-120 odds) or -2500 on the moneyline at Underdog. Minnesota bettors can get the Golden Gophers at +26.5 on the spread at BetRivers (-122 odds) or +1600 on the moneyline at FanDuel.

Minnesota vs Oregon Prediction

• Oregon 32, Minnesota 14

This Minnesota vs Oregon prediction comes down to a simple reality: the Golden Gophers can’t win on the road, and Oregon is playing for a College Football Playoff berth. Minnesota is undefeated at home but winless on the road (0-3), and the road struggles have been brutal. They’ve been outscored 83-6 in Big Ten road games.

Oregon needs to simply beat Minnesota, USC, and Washington to lock up a CFP spot. Playing at Autzen Stadium with everything on the line, the Ducks should dominate. However, Oregon has struggled to blow teams out lately, scoring 27 points or fewer in regulation in four of their last five games.

That’s why I expect a comfortable Oregon win, but one that doesn’t quite reach the 25+ point margin oddsmakers are projecting.

Minnesota Key Players

Freshman quarterback Drake Lindsey has been wildly inconsistent. In six games with multiple total touchdowns, Minnesota is 6-0. In the other three games, they’ve lost by an average of 30 points, and Lindsey has thrown four of his six interceptions.

Fame Ijeboi is coming off a 100-yard game in Minnesota’s win over Michigan State. He averages 48.0 yards per game and 4.7 yards per rush over eight games played.

The Heart of the Game is Fame Ijeboi who has 1 TD and 104 yards! #Gophers pic.twitter.com/E7Sb8TO6y3

— GopherHole.com (@GopherHole) November 1, 2025

Minnesota’s passing attack is spread around. Eight different players have at least 10 catches. Lemeke Brockington leads the team in receptions and yards, with three receiving touchdowns tied for the team lead.

On defense, Anthony Smith is the Big Ten’s sack leader with 8.5 sacks and 11.5 tackles for loss. He’ll need a huge game to disrupt Oregon’s balanced attack.

Oregon Key Players

Dante Moore has been one of the country’s best quarterbacks with 19 passing touchdowns to just five interceptions. However, his recent production has been concerning. He has just 198 total yards with zero touchdowns and one interception over the last two weeks.

There’s threading the needle and then there’s whatever the hell this is by Dante Moore.

My word.
pic.twitter.com/YgZecbuZed

— Max Chadwick (@CFBMaxChadwick) November 8, 2025

The Ducks’ rushing attack is elite. Four different running backs have at least 40 carries and all average at least 5.9 yards per rush. Noah Whittington leads with 551 yards and a conference-best 8.1 yards per carry, while Jordon Davison has 10 touchdowns.

In the passing game, tight end Kenyon Sadiq (five receiving TDs) and true freshman Dakorien Moore (team leader in catches and yards) give Oregon two future NFL Draft picks at pass catcher.

Oregon’s defense features NFL talent across the board with Matayo Uiagalelei, A’Mauri Washington, and Dillon Thieneman all projected as consensus top-50 picks in 2026.

Minnesota vs Oregon Best Bets

• Minnesota +26.5

My logic here is that Oregon has scored 27 points in regulation just once in its last five games, scoring 56 against Rutgers. While Oregon has covered 20-point spreads three times this season, they are 0-2 ATS in Big Ten games with 20-point spreads.

• Over 43.5

Both teams have favored the under in recent weeks, but 43.5 is quite a small total for a college game (that does not include Iowa). It is the lowest non-Iowa total on Oregon’s schedule this season.

Minnesota has played in four games with a total below 43.5 (including the Iowa game). The over is 3-1 in those games for this Minnesota vs Oregon best bet.

Minnesota vs Oregon Lifetime Matchups

Minnesota holds the lifetime edge 3-1, winning both regular-season matchups. However, the Golden Gophers have never made the trek to Eugene. Minnesota is 2-0 at home, and the teams split their pair of Sun Bowl matchups.

Minnesota and Oregon last played on New Year’s Eve 2003. Minnesota won a thrilling game with a last-minute field goal. Led by Laurence Maroney’s 131 yards and a touchdown, Minnesota capped off a 10-win season.

On the Oregon side, Kellen Clemens and Samie Parker hooked up 16 times for a ridiculous 200 yards and two touchdowns.