Opening College Football Week 14 Odds, Lines & Early Rivalry Week Predictions 2025

• Rivalry Week is all that remains in the 2025 regular season
• The opening betting lines have been posted for The Game, the Iron Bowl, the Egg Bowl and more
• See the opening college football Week 14 odds

Just one more week remains before conference championships and bowl season: Rivalry Week.

Still a week away, sportsbooks have already posted opening lines for Week 14. The table below sets out all the 2025 Rivalry Week odds for power-conference and top-25 teams. Under the table, I have set out my favorite early lines to target.

College Football Week 14 Odds: Rivalry Week

Rivalry Week features hyper-short road favorites. The #9 Notre Dame Fighting Irish (9-2) are laying 31.5 points at Stanford (4-7); the 2 Indiana Hoosiers (11-0) are laying 28.5 at Purdue (2-9); and the #1 Ohio State Buckeyes (11-0) are laying 12.5 at #18 Michigan (9-2).

The Buckeyes remain the outright favorite in the national championship odds, sitting as short as +175 at DraftKings. The Hoosiers are +500 second-favorites, followed by #3 Texas A&M (+700) and Notre Dame (+800).

Odds as of 11:03 am ET, Nov. 23, at DraftKings. See the latest pre-registration offers from DraftKings Missouri before sports betting launches in the state in December 2025.

Early Rivalry Week Picks & Predictions

Ohio State -10.5 (-115) at Michigan at ESPN Bet

The Buckeyes are a stunning 9-1-1 ATS despite staring down massive point spreads week after week. With several Big Ten teams suffering through down seasons (eg Penn State and Wisconsin), Ohio State hasn’t played as tough a schedule as usual. But they had no problems getting past then-#1 Texas (14-7) in Week 1, and ran over #17 Illinois on the road (34-16) in Week 7.

The Wolverines may be 9-2 and ranked inside the top 20 but their ugly 4-7 ATS record tells you everything you need to know about how they’ve performed this season compared to expectations. They have been eking out wins against teams that the Buckeyes rolled (eg Purdue). The motivation of Rivalry Week can only make up for so much discrepancy in talent, and this year, the Buckeyes are beyond superior.

While DraftKings has opened the line at OSU -12.5, ESPN Bet has it two full points lower, creating massive value on the Buckeyes.

Vanderbilt +3.5 (-110) at Tennessee at DraftKings

I have been bullish on Vandy all season and that’s not going to stop now. The Commodores only losses this season were on the road at Alabama (30-14) and Texas (34-31). Tennessee’s three losses all came against elite teams – Alabama, Georgia, Oklahoma – but the latter two came at home. The Vols are a good team but not a great one, and Vandy is more than capable of hanging with Tennessee over four quarters, regardless of location. Catching more than a field goal is a gift.