NFL Touchdown Scorer Bets for MNF: Panthers vs 49ers Anytime TD Picks

• The Panthers look to take first place in the NFC South
• Which of San Fran’s weapons will find the end zone?
• Continue reading for my expert NFL touchdown bets for Panthers vs 49ers on MNF

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Who doesn’t love a good touchdown scorer parlay? I have provided three options to consider for tonight’s MNF contest between the Carolina Panthers and San Francisco 49ers. While one is quite chalky, all three would be a great addition to a same-game parlay or a multi-sport parlay. Perhaps try a Bay Area parlay featuring George Kittle and Steph Curry.

Keep reading for my top three Panthers vs 49ers anytime touchdown picks for Monday Night Football, which will be broadcast at 8:15 pm ET on ABC/ESPN.

Best Panthers vs 49ers TD Scorer Picks

In addition to one of the chalkiest picks of the season (Christian McCaffrey), I have supplied two plus-money targets – George Kittle and Tetairoa McMillan – to score this MNF in the anytime touchdown scorer props.

Other popular bets include Rico Dowdle (-130 on ESPN Bet) and Jauan Jennings (+210 on bet365). I also like the value on Carolina’s tight ends as a sprinkle. Perhaps Tommy Tremble (+750 on bet365) scores.

CAR vs SF Touchdown Pick #1: Christian McCaffrey Anytime TD (-325 at Sports Interaction)

This is admittedly as chalk as a touchdown pick can be, but McCaffrey is one of the most reliable touchdown scorers in recent memory. As a member of the 49ers, he has 42 touchdowns in 42 regular-season games. This season, he has been up to the task, scoring 11 touchdowns in 11 games.

It is worth considering McCaffrey to score multiple touchdowns as well, a feat he has accomplished three times this season. Last week, he scored three touchdowns in the 49ers’ win over Arizona. Keep in mind this is also something of a revenge game for McCaffrey, who played 5.5 seasons with the Panthers before a 2022 trade.

Of the 28 touchdowns allowed by Carolina this season, 11 have been scored by running backs (including Dallas’ fullback, Hunter Luepke). Of these, both James Cook and Bijan Robinson scored multiple touchdowns. While McCaffrey is well-versed in the art of catching touchdowns, the Panthers have only surrendered two receiving touchdowns to backs this season (De’Von Achane and the aforementioned Luepke).

CAR vs SF Touchdown Pick #2: George Kittle Anytime TD (+140 at Fanatics)

Kittle can be hot-and-cold with scoring at times, but he has scored in four of six games this season, tallying five touchdowns in total. He scored two touchdowns last week, giving the multi-time All-Pro 50 for this career. He has at least five touchdowns in seven of the last eight seasons.

What a freakishly athletic play from George Kittle lmaopic.twitter.com/MBkG3Tl4y7

— Ian Hartitz (@Ihartitz) November 10, 2025

I suppose Kittle could rush for a touchdown, but he is overwhelmingly more likely to find the end zone through the air. Kittle has five of 20 receiving touchdowns credited to 49ers this season. He is tied with the aforementioned McCaffrey for the team lead.

The Panthers have allowed five touchdowns to tight ends this season. Three of these have come outside the 15-yard line, so the Panthers have been gashed both in the short red zone and on longer pass plays.

CAR vs SF Touchdown Pick #3: Tetairoa McMillan Anytime TD (+156 at Underdog)

McMillan has four touchdowns this season, victimizing the Cowboys and Falcons twice each in multi-touchdown outings. The rookie has been kept out of the end zone in nine of 11 games, but he has at least five targets in every game this season and a healthy 8.1 per game.

#Panthers WR Tetairoa McMillan this season:

– 54 catches (1st for rookies)
– 748 yards (1st for rookies)
– 4 TDs (T-3rd for rookies) pic.twitter.com/v9aYDAy1tf

— Ari Meirov (@MySportsUpdate) November 20, 2025

“T-Mac” has caught four of the 15 receiving touchdowns Carolina has on the season. He is one ahead of Xavier Legette for the team lead. He has nearly twice as many targets as any other Panther, and he had nearly 500 more yards than the second-most on the team.

Of the 30 touchdowns allowed by the 49ers this season, 12 have been surrendered to wide receivers. This includes Puka Nacua in both Rams-49ers games and an 87-yard punt return from Parker Washington. No receiver has scored multiple touchdowns in one game against the 49ers yet this season.