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Duke vs Pitt Picks & Predictions for Tuesday’s Game on ESPN

By Jordan Tomiyama in College Basketball

Published:


Duke Team Huddling
Jan 10, 2026; Durham, North Carolina, USA; Duke Blue Devils players (left to right) Pat Ngongba II, Cameron Boozer, Cayden Boozer, and Caleb Foster huddle during the second half against the Southern Methodist Mustangs at Cameron Indoor Stadium. Mandatory Credit: Rob Kinnan-Imagn Images
  • No. 4 Duke looks to get back in the win column as they travel to play unranked Pittsburgh
  • The Blue Devils are big road favorites, so you could be looking at props instead of spread bets
  • See my top Duke vs Pittsburgh picks and predictions for this Tuesday night matchup

It’s an ACC tilt as No. 4 Duke Blue Devils (21-2,10-1 ACC, 5-1 Away, 12-7 ATS) go into enemy territory against the Pittsburgh Panthers (9-15, 2-9 ACC, 1-5 Home, 9-15 ATS).at 9:00 pm ET on Tuesday, February 10. This contest gets national attention on an ESPN broadcast.

The Panthers have struggled so far this season and sit last in the ACC. The Blue Devils will be a motivated bunch as they’ll be looking to rebound after their heartbreaking loss to arch-rival North Carolina on Saturday (71-68). The Panthers have three players who average double-figures with Brandin Cummins leading the way with 12.5 points per game. Cameron Boozer is averaging a double-double for the Blue Devils and he dropped 24 against the Tar Heels.

The Blue Devils head into tonight’s game as a massive road favorite, laying 17.5-points in the Duke vs Pitt odds, which are set out in full in the table below.

Duke vs Pitt Betting Lines & Odds

TeamSpreadMoneylineTotal
Duke-17.5 (-110)-3500Ov 135.5 (-110)
Pitt+17.5 (-110)+1280Un 135.5 (-110)

On the moneyline, Duke is an unbettable -3500 to win straight-up. Pitt comes back as a +1280 longshot to pull off the upset. The game total is 135.5 with -110 odds each way.

Odds as of 10:22 am ET at FanDuel. Find the best online sportsbook for college basketball.

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Duke vs Pittsburgh Picks, Predictions & Best Bets

Duke will have all the motivation in the world to get a bounce-back victory tonight and Cameron Boozer will be leading the charge. He’s usually the best player on the court and that shouldn’t change tonight.

Cameron Boozer Over 22.5 points (-110 at FanDuel)

The Duke forward is a top NBA prospect and one of the best freshman in the country. He has scored at least 23 points in four of the last six games. Boozer’s ability to stretch the floor makes him a nightmare to guard. The 6’9 forward has hit at least one three in six straight contests.

Boozer is a menace on the glass and gets a ton of put-back layups from crashing the glass for offensive rebounds. He’s pretty solid from the free-throw line, as well, shooting 76% from the stripe this season. His season-high for points is 35 and the Duke forward has dropped 30 or more points in four contests this year.

Cameron Cohen Over 10.5 points (-105 at FanDuel)

If the Pittsburgh Panthers want any chance of staying tight with the Blue Devils, Cameron Cohen will have to be a force for his team. He’s averaging 12.3 PPG while grabbing 7.4 rebounds. He has scored at least 10 points in three of his last five matchups.

The 6’10 power forward is producing 11.9 points per game at home and plays just over 34 minutes a contest. Look for Cohen to get plenty of touches in the paint and also be aggressive attacking the paint. The Panthers do have some three-point threats so Duke may not have the option to send the double team.

Duke vs UNC Betting Splits

Tuesday’s college basketball public betting splits show little faith in Pittsburgh pulling off a moneyline upset.

Moneyline Splits

Duke Blue Devils: 96% of Bets / 95% of Money

Pittsburgh Panthers: 4% of Bets / 5% of Money

There’s not a lot of value in taking the Blue Devils moneyline or even adding to a parlay in this case.

ATS Splits

The betting public does think that Duke will cover the spread but the contingent that believes the Panthers will cover the massive number is considerably bigger than the group betting Pitt to win outright.

Duke Blue Devils: 66% of Bets / 83% of Money

Pittsburgh Panthers: 34% of Bets / 17% of Money

Total Market

The public is expecting a lot of offense and not a ton of defense tonight. A blowout could impact the number if Duke takes its starters out early.

Over 135.5: 90% of Bets / 91% of Money

Under 135.5: 10% of Bets / 9% of Money

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