Top PrizePicks Lines for Friday Night March Madness Games

The second day of the NCAA Tournament always brings chaos, and Friday’s late slate is no exception. With tighter rotations, increased minutes, and stars taking on bigger roles, the late games present some of the best opportunities to find value on PrizePicks.

For DFS-style pick’em contests, that combination creates a clear edge. Targeting high-usage players in competitive matchups is the foundation for building strong entries, especially in the late window where game environments tend to stay close. If you’re building entries on the best DFS apps for the night window, targeting high-usage players and competitive matchups is key. Here are some of the top PrizePicks lines to consider for Friday’s late March Madness action.

My Picks for Friday Night Slate of CBB Games

Braden Smith (Purdue) vs Queens Less than 30.5 points+rebounds+assists

Fading Braden Smith under 30.5 P+R+A is a smart play in Friday’s matchup against Queens University. His season averages sit closer to 27-28 P+R+A, so this line is slightly inflated and requires a near-ceiling performance to hit. Much of his production comes from assists, which can drop if teammates struggle or if Queens’ defense slows Purdue’s offense. With scoring likely in the low-to-mid teens, backing Smith to stay near his season averages makes the under a solid, data-driven angle in this March Madness matchup.

Dontae Horne (Prairie View A&M) vs Florida more than 27.5 points+rebounds+assists

Taking Dontae Horne over 27.5 P+R+A in Friday’s matchup against Florida University is an appealing play. Horne is the focal point of Prairie View A&M’s offense, logging heavy minutes and handling the ball on nearly every possession. He contributes across points, rebounds, and assists, giving him multiple ways to reach the 27.5 P+R+A mark. In a competitive tournament setting, where he’ll be relied on to generate offense and create opportunities for teammates, Horne has the upside to exceed this line, making the over a strong, data-backed play for PrizePicks.

Dylan Darling (St. John’s) vs Northen Iowa less than 9 points

Fading Dylan Darling’s points in Friday’s game against Northern Iowa is worth considering. While Darling is the primary ball-handler for the Red Storm, his production heavily depends on teammates converting shots, and Northern Iowa’s disciplined, slow-paced defense could limit his assist opportunities. Scoring upside is also capped in a game expected to stay low-tempo. Given the projected pace and defensive focus, backing Darling to finish below his point line presents a strong under play in this matchup.

Eric Dailey (UCLA) vs UCF more than 20 points+rebounds+assists

Taking Eric Dailey over 20 P+R+A in Friday’s matchup is a solid play. Dailey is a key contributor for UCLA, impacting the game across points, rebounds, and assists. He typically logs heavy minutes, and in a competitive March Madness setting, he’ll be relied on to handle the ball, attack the basket, and create opportunities for teammates. With multiple ways to accumulate stats, Dailey has the upside to surpass 20 P+R+A, making the over a strong, data-driven pick for PrizePicks entries.

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