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NFL Draft Round 2 Odds – Prediction for First Pick (33rd Overall)

Chris Amberley

By Chris Amberley in NFL News

Published:


Emmanuel McNeil-Warren makes a big tackle vs Washington State.
Oct 25, 2025; Pullman, Washington, USA; Washington State Cougars quarterback Zevi Eckhaus (4) is tackled by Toledo Rockets safety Emmanuel McNeil-Warren (7) in the second half at Gesa Field at Martin Stadium. Mandatory Credit: James Snook-Imagn Images
  • Toledo saftey Emmanuel McNeil-Warren has the shortest price to be taken 33rd overall
  • McNeil-Warren is drawing comparisons to the Seahawks Nick Emmanwori, and fills a need for the 49ers who are on the clock
  • See the NFL Draft Round 2 odds and my prediction for the first pick on Friday night

The 49ers didn’t like what they saw in the back end of Round 1 of the NFL Draft, ultimately trading down and then out of the top-32 altogether. Day 2 of the Draft will now begin with San Fran on the clock, and prediction markets are taking bets on who that pick will be.

Toledo safety Emmanuel McNeil-Warren is taking the most action to be the selection, followed by Washington wide receiver Denzel Boston. These two have yo-yoed back and forth atop this market all day, with Boston being favored as late as 4 pm ET. Since then, money has come pouring in on McNeil-Warren, and for good reason as I’ll explain.

Keep reading to see the latest NFL Draft Round 2 odds, and my prediction for the first pick at #33 overall.

NFL Draft Round 2 Odds for #33 Pick

Prediction Markets
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Kalshi
Emmanuel McNeil-Warren
29%
Denzel Boston
20%
Kayden McDonald
9%
Colton Hood
8%
Chase Bisontis
8%
Zion Young
8%
Treydan Stukes
5%
Cashius Howell
4%
Jermod McCoy
3%
Emanuel Pregnon
3%

At the time of writing, McNeil-Warren is being given a 29% chance to be the Niners selection by Kalshi. That’s down from his peak of 45% in the wee hours of the morning, and his current 29 cent price is the equivalent of +245 odds in conventional sports betting terms.

Boston meanwhile, is trading at 19 cents in the NFL Draft odds futures market (+426), after seeing his price as high as 41 cents earlier in the day. Texas A&M offensive tackle Chase Bisontis is also in the running to be pick #33, but I’m not convinced San Fran believes his talent is worthy of such a high selection.

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NFL Draft Round 2 Prediction for First Pick

  • Emmanuel McNeil-Warren (29ยข at Kalshi)

The main reason San Fran traded out of last night’s pick was they felt they missed out on a couple players they were targeting. Word out of Niners camp is they coveted a tackle, but with the best o-line prospects off the board it’s time they turn their attention to another need. Apologies to Denzel Boston, but that’s not a wide receiver.

The 49ers appear more than set at that position. Sure, they’re losing Brandon Aiyuk, who looks like he’s trying to eat himself out of the league, but they made a big splash in free agency to compensate. The Niners gave QB Brock Purdy both Mike Evans and Christian Kirk this offseason to complement former 1st Round pick Ricky Pearsall.

The most glaring hole on San Fran’s roster is at the safety position. Neither starter Ji’Ayir Brown or Malik Mustapha gave them even competent play last season, and the stats bare that out. The Niners defense ranked dead last in success rate. Only a handful of teams allowed a higher EPA per pass, while their run defense was a bottom-12 unit per that metric as well.

San Fran needs a player that can affect the game both on the ground and through the air, and have to be salivating over McNeil-Warren’s upside. He’s being comped to NFL DROY odds Nick Emmanwori, who just helped the Seahawks hoist the Lombardi trophy. Emmanwori’s versatility was a big reason Seattle reigned supreme in the Super Bowl odds, and I bet many teams around the league are looking for their own version of that type of player.

McNeil-Warren is a three-year starter and should be able to hit the ground running. He’s got excellent size and speed, which allows him to defend in the box but also in pass coverage against tight ends and bigger wideouts. San Fran hasn’t had this type of defender since they lost Jimmy Ward, and McNeil-Warren also has a knack for creating turnovers.

He forced 9 fumbles last year for Toldeo and hauled in 5 interceptions. Pair him with new defensive coordinator Raheem Morris, who has a DB background, and it’s a perfect match.

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Chris Amberley
Chris Amberley

Sports Writer

As SBD's resident Swiss Army Knife, Chris covers virtually every sport including NFL, PGA, NBA, MLB, NCAAB, NCAAF and the Olympics. A true grinder, he'd rather pick off small edges in the player props market than swing for the fences with a 5-leg parlay.

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