Best Home Run Picks & Odds Across Today’s MLB Slate

Published: July 22, 2026 at 9:13 am EDT

Riley Greene hi-fives in dugout — Detroit Tigers left fielder Riley Greene (31) celebrates batting a one run home run against Minnesota Twins during the second inning at Comerica Park in Detroit on Tuesday, June 9, 2026.

Target high-leverage power hitters exploiting favorable pitching matchups across a ballyhooed 17-game MLB slate.
Capitalize on hitter-friendly MLB park factors like Coors Field and Citizens Bank Park to find actionable prop betting value.
Back narrative-driven sluggers like Shohei Ohtani and James Wood as they step into the box against arms struggling with volume and pitch-to-contact metrics.

Home Run Odds & Best Bets for Today

Today’s 17-game MLB slate offers plenty of home run prop value, especially in power-friendly parks like Coors Field, Wrigley Field, Yankee Stadium, and Citizens Bank Park. Below, we highlight the best MLB home run probabilities today by matchup, park factor, and price.

Below, you will find a full breakdown of MLB home run props spanning multiple games. We will analyze the premier hitters stepping into the box against elite arms like Aaron Nola and Gerrit Cole. We will break down why certain superstars are top targets tonight, while also identifying a high-upside longshot from the late-night slate to round out your betting card.

Home Run Picks Today

Matchup	Pick	Best Odds
WSH Nationals at COL Rockies	James Wood	+204
DET Tigers at CHC Cubs	Riley Greene	+454
SF Giants at KC Royals	Heliot Ramos	+432
LAD Dodgers at PHI Phillies	Shohei Ohtani	+210
NY Mets at MIL Brewers	Juan Soto	+263
PIT Pirates at NY Yankees	Ben Rice	+217

James Wood (+204) — Washington Nationals at Colorado Rockies

The ultimate launching pad in baseball always demands attention. Coors Field stands out today as the fifth-highest scoring park in the league, yielding an impressive 2.73 home runs per game. James Wood and the Washington Nationals face Rockies starter Gabriel Hughes, who has yet to allow a home run in a limited 14.1-inning sample.

However, the underdog mentality of this Nationals lineup combined with the altitude in Denver makes this a high-leverage spot. The spacious outfield gaps create an ideal environment for a powerful rookie like Wood to clear the fences. The undeniable Coors Field factor alone validates this as a ballyhooed option on the daily fantasy market.

Riley Greene (+454) — Detroit Tigers at Chicago Cubs

Riley Greene and the Detroit Tigers bring their gritty, hard-working ethos to Wrigley Field. This venue currently ranks seventh in runs per game and generates a massive 2.80 home runs per matchup. Greene draws a high-upside assignment against Chicago Cubs starter Colin Rea, who has struggled significantly with the long ball this season.

Rea has surrendered 15 home runs over 100.2 innings, translating to an elevated 1.341 HR/9 rate. This pitch-to-contact vulnerability provides a tactical edge for those studying volume metrics. Combined with the favorable hitting conditions at Wrigley, Greene possesses a formidable foundation to deliver a clutch swing today.

Heliot Ramos (+432) — San Francisco Giants at Kansas City Royals

Heliot Ramos takes aim at Kauffman Stadium, a park that currently sits eighth overall in run production while averaging 2.33 home runs per contest. Ramos will be swinging against Royals veteran Seth Lugo. Lugo has allowed 15 home runs across 110.2 innings this year, resulting in a 1.220 HR/9 rate that DFS managers have eagerly circled.

Lugo’s clear presence on the slate’s list of highest HR/9 starters gives Ramos a definitive path to clearing the outfield wall. Showcasing the relentless work ethic that earned him his spot in the lineup, Ramos provides excellent value for bettors looking to capitalize on favorable pitching matchups.

Shohei Ohtani (+210) — Los Angeles Dodgers at Philadelphia Phillies

Shohei Ohtani steps into a highly favorable environment at Citizens Bank Park, which produces a healthy 2.71 home runs per contest. Even more enticing is his matchup against Phillies starter Aaron Nola. Nola currently sports a massive 2.010 HR/9 rate across 103.0 innings of work, making him one of the most home-run-susceptible arms taking the mound today.

With Ohtani’s raw talent and Nola’s clear tendency to surrender the long ball, this is a prime spot to back the superstar. Ohtani’s discipline at the plate perfectly counters Nola’s pitching style, creating a ballyhooed matchup.

Juan Soto (+263) — New York Mets at Milwaukee Brewers

Juan Soto will look to do damage at American Family Field against Brewers starter Logan Henderson. While this park ranks slightly lower in overall run production, it still sees 2.02 home runs leave the yard on average. Henderson has yielded three home runs in his 33.1 innings of work, equating to a 0.810 HR/9 rate.

Soto’s elite, disciplined swing is built to exploit pitchers who rely too heavily on finding the zone. When a starter is allowing nearly a home run per nine innings, a hitter with Soto’s pedigree rarely misses the mistake. His background of relentless preparation creates a formidable edge for this specific prop wager.

Ben Rice (+217) — Pittsburgh Pirates at New York Yankees

Ben Rice and the Yankees host the Pirates in the Bronx, bringing a quintessential underdog mentality to a lineup filled with established stars. Yankee Stadium is historically known for its short porch, currently ranking 13th in runs per game and producing 2.74 home runs per contest. Rice faces Pittsburgh starter Mitch Keller.

Keller has given up 13 home runs in 103.1 innings, resulting in a 1.132 HR/9 mark. Facing a pitcher prone to yielding elevated power numbers in a park strictly built for home runs offers excellent justification for Rice to hit one out tonight.

Daniel Destler

Danny Destler is a daily fantasy sports (DFS) and sports betting expert. A graduate of Marist University, Dan covers a wide range of sports topics, creating engaging and evergreen content for DFS enthusiasts and casual fans.