Picks, Predictions & Splits for Cardinals vs Reds

• The St Louis Cardinals are -115 road favorites in their series finale against the Cincinnati Reds
• Michael McGreevy offers a pitching advantage over Brady Singer’s high WHIP
• Read below for the my Cardinals vs Reds picks, predictions, updated odds and betting splits

The St. Louis Cardinals (65-63) wrap up their series extended 5-game series against the Cincinnati Reds (61-66) this afternoon, with both teams having taken two each to start this set.

Heading into today’s matchup, Cincinnati sends starter Brady Singer to the mound as a home favorite, while St. Louis counters with Michael McGreevy as the road underdog in the MLB probable pitchers.

First pitch is scheduled at 12:40pm ET at Great American Ball Park in Cincinnati, with MLB TV carrying the broadcast.

I am looking at MLB odds to find the best value for this National League contest.

Cardinals vs Reds Picks

In their last meeting on August 19, Cincinnati secured a 5-4 victory. The Reds capitalized on an error-free defensive performance and a key home run from Sal Stewart to edge out the win, surviving a late push from St. Louis that featured a Jordan Walker home run.

The Pick: Cardinals Moneyline (51¢ at Kalshi)
St. Louis brings a distinct pitching advantage into this contest. McGreevy has been highly effective, posting a 3.48 ERA and a 1.22 WHIP across 132.0 innings. Conversely, Singer has struggled with a 4.66 ERA and an elevated 1.44 WHIP over 125.2 innings.

St. Louis enters this matchup having won 60.0% of its last 10 games (6-4 straight up). Over that span, the Cardinals boast a 66.7% win rate as favorites. While they are road underdogs here, their stronger overall bullpen (4.20 ERA vs Cincinnati’s 4.57 ERA) gives them an analytical edge. You can find better payouts for this moneyline pick on Kalshi (51¢ for “Yes”) compared to traditional sportsbooks.

The Total: Under 8.5 Runs (45¢ at Kalshi)
Both offenses carry a sub-.700 OPS on the season. St. Louis sits at .699, and Cincinnati is just behind at .696. The Cardinals’ games have consistently skewed lower scoring, hitting the Over in just 37.5% of their contests this season.

Neither team consistently drives the ball for extra bases, making a lower-scoring affair the mathematically sound approach. Taking “No” on the Over 8.5 runs scored at Kalshi for 45¢ offers excellent value.

STL Cardinals vs CHI Cubs Predictions

• Brady Singer Under 4.5 Pitcher Strikeouts (-146 at Caesars): Singer averages 7.45 strikeouts per nine innings. To surpass this MLB pitcher strikeout props line, he would need to pitch deep into the sixth inning. That is difficult given his 1.44 WHIP and the patient St. Louis lineup.
• Elly De La Cruz Over 1.5 Total Bases (-125 at Caesars): De La Cruz boasts an .808 OPS and a .468 slugging percentage. His dynamic extra-base ability offers strong value.

Cardinals vs Cubs Odds & Betting Splits

The graphic above shows the best available odds, which are subject to change. Be sure to use the BetMGM promo code to bet on Cardinals vs Reds or any other MLB game. And don’t forget to check out the MLB batter vs pitcher stats before making your prop bets.

Oddsmakers initially priced this game as a true pick’em, with both teams opening at -105 on the moneyline. Steady action on the visiting team shifted the lines, pushing St. Louis to a -110 road favorite at traditional sportsbooks like FanDuel, while the Reds moved to +105 on bet365. This movement aligns with the MLB public betting splits, as 59% of the moneyline wagers back St. Louis.

However, there is a divergence between the general public and the money flow. While St. Louis holds the ticket advantage, Cincinnati commands 64% of the overall money on the moneyline. Despite this financial lean toward the home underdog, my statistical breakdown favors fading the money and backing the road team.

On the spread, taking the Cards to win by at least two runs pays out at a nice +140, while taking the Reds and the extra 1.5 runs comes with -154 juice. The public loves St Louis here, with 87% of the money on them covering on 59% of the tickets

In the totals market, bettors and bigger bankrolls are aligned. The Under has drawn 50% of the tickets and 59% of the money. Trusting the Under aligns with both my analysis and the broader market’s financial lean on a lower-scoring game. Over bettors can go to Caesars to find the 9.0 line, with +100 odds, while Under bettors can find an extra half-run at bet365, with a 1-54 payout.