Opening College Football Week 13 Lines, Odds & Best Bets 2025
By Sascha Paruk in College Football
Published:
- The NCAAF Week 13 odds and betting lines are out
- Week 13 is highlighted by #17 USC vs #8 Oregon
- See the opening college football Week 13 odds for all P4 and ranked teams
After a massive Saturday in which six top-25 teams lost outright, the lines have been posted for NCAAF Week 13.
The Week 13 slate is light on ranked-vs-ranked matchups, but there are a few games that carry big implications for the CFP odds, most-notably #17 USC visiting #8 Oregon. Week 13 also brings the latest iteration in the fierce Florida/Tennessee rivalry
The table below lists the college football Week 13 odds for all games involving power-conference and/or ranked teams.
College Football Week 13 Odds
Still undefeated heading into Week 13, the #1 Ohio State Buckeyes are massive +185 favorites in the latest national championship odds. The #2 Indiana Hoosiers – also undefeated – are a distant +500 second-favorite. Alabama faded from third-favorite to eighth at +1500 after losing at home to Oklahoma.
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Odds in the table as of 10:58 am ET, Nov. 16, at DraftKings. See the latest offers from DraftKings Missouri if you live in the Show-Me State.
Early NCAAF Week 13 Picks & Best Bets
Georgia Tech -2.5 (-118) vs Pitt at FanDuel
The most significant advantage belongs to Georgia Tech’s ground attack facing Pittsburgh’s run defense. The Yellow Jackets’ 224.6 rushing yards per game will look to find success against the Panthers’ run defense.
Pittsburgh’s defensive strength lies in generating turnovers, specifically 1.2 interceptions per game. But Haynes King has only tossed two picks all season, and the Yellow Jackets’ run-heavy approach limits his chances to toss picks.
USC +8.5 (-113) at Oregon at Underdog
USC has shown an ability to rise to the occasion when disrespected by oddsmakers. More specifically, the Trojans have a tendency to keep games closer than expected in high-leverage situations when catching 7+ points.
Oregon, despite its home-field advantage, has shown varied ATS results as a home favorite of 7+ points over the past two seasons, suggesting the market overvalues the Ducks’ dominance at Autzen.
- BETMGM SPORTSBOOK
USE CODE SBD1500 TO GET UP TO $1,500 PAID BACK IN BONUS BETS
- BET365 SPORTSBOOK
BET $10 & GET $200 IN BONUS BETS
- THESCORE BET SPORTSBOOK
USE CODE DIME TO GET 100% BET RESET UP TO $1,000
- DRAFTKINGS SPORTSBOOK
BET $5 & GET $100 IN BONUS BETS INSTANTLY!
- FANDUEL SPORTSBOOK
BET $5 & GET $150 IN BONUS BETS IF YOUR BET WINS!
- CAESARS SPORTSBOOK
USE CODE SBDDYW & DOUBLE YOUR WINNINGS ON YOUR FIRST 10 WAGERS!
- FANATICS SPORTSBOOK
GET 100% BET MATCH UP TO $100 FOR 10 DAYS
DRAFTKINGS T&Cs: GAMBLING PROBLEM? CALL 1-800-GAMBLER or 1-800-MY-RESET, (800) 327-5050 or visit gamblinghelplinema.org (MA). Call 877-8-HOPENY/text HOPENY (467369) (NY). Please Gamble Responsibly. 888-789-7777/visit ccpg.org (CT), or visit www.mdgamblinghelp.org (MD), 1-800-981-0023 (PR). 21+ and present in most states. (18+ DC/KY/NH/PR/WY). Void in NH/OR/ONT/PR. Eligibility restrictions apply. On behalf of Boot Hill Casino (KS). Pass-thru of per wager tax may apply in IL. 1 per new DraftKings customer. $5+ first-time bet req. Max. $100 issued as non-withdrawable Bonus Bets that expire in 7 days (168 hours). Stake removed from payout. Terms: sportsbook.draftkings.com/promos. Ends 5/31/26 at 11:59 PM ET.
BET365 SPORTSBOOK T&Cs: GAMBLING PROBLEM? CALL OR TEXT 1-800-GAMBLER (AZ/CO/IL/IN/KS/KY/LA/MD/MO/NC/NJ/OH/PA/TN/VA) or 1-800-BETS OFF (IA). 21+ only (18+ KY). Must be present in AZ/CO/IA/IL/IN/KS/KY/LA (select parishes)/MD/MO/NC/NJ/OH/PA/TN/VA. Minimum $10 deposit required. Minimum odds -500 of greater. Bonus Bets wager excluded from returns. New customers only. T&CS, time limits and exclusions apply.
BETMGM T&Cs: Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US), 877-8-HOPENY or text HOPENY (467369) (NY), 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in MS, NY, NV, ON, or PR.
Managing Editor
Sascha has been working in the sports-betting industry since 2014, and quickly paired his strong writing skills with a burgeoning knowledge of probability and statistics. He holds an undergraduate degree in linguistics and a Juris Doctor from the University of British Columbia.
