Updated Week 10 College Football Odds: Latest Spreads & Biggest Moves (Nov. 7)

• A four-point swing in South Bend leads the Week 10 college football odds update.
• One SEC total has fallen six points heading into Saturday.
• Read below for every key-number crossing in the Week 10 college football spreads.

The Week 10 college football odds have moved a lot since our opening Week 10 lines went up Sunday. A few spreads have crossed key numbers, and one total has dropped hard.

Miami vs Notre Dame and Oregon vs Ohio State headline Saturday, and both spreads have moved by at least three points. Alabama vs LSU and Georgia vs Ole Miss have moved too.

Below, I lay out where each number opened, where it sits Friday and how that changes the result on your ticket.

Updated Week 10 College Football Odds

BetMGM odds as of Friday; opening lines from our Nov. 1 opening-odds article. Get the best prices with our College Football betting apps.

Miami vs Notre Dame Spread Climbs Through 7

The biggest move in the Week 10 college football spreads is in South Bend. Notre Dame opened as a 3.5-point favorite against Miami and sits at -7.5 at BetMGM, a four-point gap that runs straight through 7.

That changes a lot of outcomes. A Notre Dame win by four to seven points covered the opener but loses at -7.5. Miami bettors now cover with any loss of seven or fewer.

Miami will be without Malachi Toney after a high ankle sprain in Wednesday’s practice. Our Miami vs Notre Dame odds and injury update covers the surgery news and his 73 catches, 1,027 yards and 13 touchdowns. The Irish were already -5.5 before the injury, so the full four-point gap from Sunday cannot be attributed to Toney’s absence.

Week 10 College Football Spreads Around Key Numbers

Texas vs Missouri Spread Drops Below 3

Texas opened -3.5 at Missouri and is now -2.5, crossing the most common margin in football. A three-point Longhorns win lost at the opener and now covers.

Missouri bettors feel it the other way. At +3.5, a three-point loss covered, but at +2.5 that same result loses.

Oregon vs Ohio State Spread Narrows by Three Points

Ohio State opened -10.5 against Oregon and sits at -7.5, a three-point drop that crosses 10 but stays above 7. A Buckeyes win by eight, nine or 10 points lost at the opener and now covers.

A seven-point Ohio State win still loses for Buckeyes bettors at either number. Oregon backers at +7.5 cover with any loss of seven or fewer.

Alabama vs LSU and Georgia vs Ole Miss Odds

LSU moved two points, from -4.5 to -6.5 against Alabama. A five- or six-point Tigers win covered the opener but loses now. Follow the latest Alabama vs LSU odds before kickoff.

Georgia went from -3 to -3.5 at Ole Miss. That half point turns a three-point Bulldogs win from a push into a loss.

Utah hasn’t moved off -4.5 against BYU. Friday’s Virginia Tech vs SMU spread is also unchanged, with the Mustangs laying 6.5 points.

Week 10 College Football Totals Movement

The biggest totals move in the Week 10 college football odds is Texas at Missouri, down six points from 48.5 to 42.5. UCLA vs Minnesota has also dropped four points to 38.5, the lowest total on this board.

Miami vs Notre Dame, Georgia vs Ole Miss and Kentucky vs Tennessee each slipped a point. Oregon vs Ohio State rose one to 46.5, while Iowa vs Northwestern climbed three points to 45.5.

BYU vs Utah held at 48.5 and Alabama vs LSU stayed at 52.5. Friday’s Virginia Tech vs SMU total is unchanged at 56.5, the highest of this group.

These updated Week 10 CFB odds show how much the number matters. The same final score can produce a different betting result depending on when you placed the bet.