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Chargers vs Chiefs Odds, Betting Lines, Picks & Predictions for NFL Week 2 TNF

Robert Duff

by Robert Duff in NFL Football

Updated Sep 14, 2022 · 12:56 PM PDT

Chargers vs Chiefs odds
Dec 16, 2021; Inglewood, California, USA; Kansas City Chiefs quarterback Patrick Mahomes (15) runs the ball against the Los Angeles Chargers in overtime at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports
  • The Kansas City Chiefs are 4-point home favorites over the Los Angeles Chargers in the NFL Week 2 TNF game on Thursday, September 15
  • TNF record ML: 0-0; ATS 0-1; O/U 0-0, -1 unit
  • The Chiefs are 6-0 straight up over their past six regular-season home games. See the odds and our Chargers vs Chiefs picks below

A week 2 matchup on TNF between the Kansas City Chiefs (1-0) and Los Angeles Chargers (0-1) can be beneficial for both teams. It all comes down to how you opt to analyze the data.

The Chiefs are a stellar 36-5 straight up in their last 41 games when facing AFC West opposition. Kansas City is 6-0 SU in the team’s last six regular-season home games.

On the other hand, the Chargers are 5-2 against the spread in their last seven games at Kansas City. LA is also 5-2 ATS in the club’s last seven games played on a Thursday.

Chargers vs Chiefs Odds

Team Spread Total Moneyline
Los Angeles Chargers +4 (-110) O 54.5 (-110) +175
Kansas City Chiefs -4 (-110) U 54.5 (-110) -210

Odds as of September 14 at Caesars Sportsbook. See the available Caesars Sportsbook promo code for the NFL here

Oddsmakers are backing Kansas City at home. The Chiefs are set at 4-point favorites. KC is 8-3 ATS over the last 11 games.



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Kickoff at GEHA Field at Arrowhead Stadium is set for 8:15 pm ET on Thursday, September 15. The weather forecast is calling for clouds, 14 mph wind and a temperature of 94 degrees.

The game will be exclusively aired on Amazon Prime as part of a new partnership for Thursday Night Football with Amazon.

Chargers vs Chiefs NFL Betting Trends

In NFL public betting trends, people are backing the Chiefs in a big way. Spread wagering is showing 78% of the handle and 77% of bets are on Kansas City. In moneyline wagering, 61% of the handle and 63% of bets are supporting the Chiefs. The over is getting 73% of bets. However, it’s the under that’s drawing 69% of the handle. The over has proven to be the winning play in nine of LA’s last 11 games and eight of KC’s last 11 games.


The Chiefs (+800) and Chargers (+1300) are listed at 3-4 in the Super Bowl odds. Kansas City is the +125 chalk to win the AFC West. LA is at a betting line of +190 in the NFL divisional odds.

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Can Chargers Pressure Chiefs’ Mahomes?

The Chargers beat the Chiefs 30-24 in LA during Week 3 of the 2021 season. One of the keys to that victory was that the LA defense was able to disrupt KC quarterback Patrick Mahomes. And that was without All-Pro LB Khalil Mack.

The Chargers sacked Mahomes twice. The pass rush pressure they were able to exert also helped lead to two interceptions. As well, the Kansas City offense lost two fumbles in that game.

However, when the two teams met again in Week 15 at Kansas City, Mahomes threw for 410 yards and three TDs. The Chiefs won 34-28. However, the Chargers were still able to sack Mahomes once, pick him off once and force him to lose a fumble.

Butker Injury a Concern for KC

Chiefs kicker Harrison Butker is listed as questionable for this game. He suffered an ankle injury in the Week 1 win at Arizona. Safety Justin Reid came on to kick an extra point for Kansas City. The Chiefs are working out kicker Tristan Vizcaino just in case Butker can’t go on Thursday.

Chiefs right guard Trey Smith is also questionable with an ankle injury.

The Chargers are also dealing with a key injury and it’s not looking good. Head coach Brandon Stanley thinks it’s unlikely that WR Keenan Allen will be playing Thursday. LA’s leading receiver left the Week 1 win over the Las Vegas Raiders with a hamstring injury. He hasn’t practiced this week. Allen caught at least 100 passes in four of the past five seasons.

Chargers starting left cornerback JC Jackson (ankle surgery), missed last week’s game and is listed as questionable to play on Thursday.

Chargers vs Chiefs Prediction

In four starts against the Chiefs, Chargers QB Justin Herbert is 1-3 SU. He’s thrown for 830 yards and 10 TDs against two interceptions.

Both teams won and covered in Week 1 victories against 2021 playoff teams. Of note though, without Jackson available for coverage, Raiders wideout Davante Adams went off for 10 catches and 141 yards.

Mahomes took advantage of an ailing secondary while throwing for five TDs against Arizona. If Jackson can’t go, then go with the Chiefs to cover. With Kansas sports betting now live, bettors can make this wager and more for their Chargers vs Chiefs picks on TNF.

Pick: Kansas City Chiefs -4 (-110), 1 unit

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