NFL DFS Week 10 Lineup: DraftKings Picks for Sunday

Week 10 of the NFL season is here, and plenty of opportunities remain on the DraftKings Fantasy main slate. This lineup blends high-volume stars, affordable upside plays, and a few lower-priced options to free up salary for the top of the roster.

The lineup comes in at exactly $50,000, leaving no salary on the table. Here are my DraftKings NFL best daily fantasy picks for Sunday’s Week 10 slate.

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DraftKings NFL DFS Lineup

DraftKings NFL DFS Picks and Lineup Breakdown

QB: Matthew Stafford ($6,200) – LAR @ ARI

Stafford offers a strong combination of passing volume and touchdown upside at a reasonable $6,200 salary. He has thrown for 2,374 yards and 16 touchdowns through nine games, averaging more than 263 passing yards per contest. He also has multiple passing touchdowns in five games this season, including a four-touchdown performance against the Giants and a three-touchdown outing against the Bills. Arizona is a familiar divisional opponent, and Stafford already threw for 222 yards and two touchdowns against the Cardinals earlier this season.

RB: James Cook III ($7,400) – BUF @ NYJ

Cook is one of the safest volume plays in this lineup. He is coming off a 107-yard rushing performance against Minnesota and has recorded at least 80 rushing yards in four of his last five games. He has also scored a rushing touchdown in each of his last four appearances, giving him a strong combination of workload and scoring upside. The $7,400 price tag is substantial, but Cook’s recent production makes him a strong foundation for this lineup.

RB: Ashton Jeanty ($5,400) – SEA @ LV

Jeanty is an intriguing value option, particularly because of his involvement in the passing game. While his rushing production has been inconsistent, he has shown the ability to contribute as a receiver, recording eight catches for 61 yards against the Rams and another 64 receiving yards against the Jets. His workload has fluctuated recently, so he carries some risk, but his receiving ability gives him another path to fantasy production beyond rushing yards.

WR: Denzel Boston ($5,200) – HOU @ CLE

Denzel Boston is listed at just $5,200, making this an affordable way to fill a wide receiver spot while saving salary for higher-priced players. Houston’s defense has allowed 187.4 receiving yards per game to opposing wide receivers through Week 8, the third-highest total in the league. That matchup creates some potential upside for Cleveland’s passing game.

WR: Jalen Coker ($5,700) – CAR @ NO

Coker has shown legitimate upside this season, highlighted by an eight-catch, 138-yard, two-touchdown performance against Chicago in Week 1. He also caught six passes for 97 yards against Philadelphia in Week 6. His production has been inconsistent, but he has shown he can deliver a big fantasy performance when Carolina gets him involved. At $5,700, Coker provides some salary flexibility with upside in the Panthers’ passing game.

WR: Justin Jefferson ($6,800) – MIN @ GB

Jefferson remains one of the most talented receivers in football and has the target volume to deliver a strong DFS performance. He has scored four receiving touchdowns this season and has recorded at least 79 receiving yards in multiple games. Green Bay allows 152 receiving yards per game to opposing wide receivers, so this matchup gives Jefferson an opportunityto make an impact. His $6,800 salary is reasonable for a player with his ceiling.

TE: Darren Waller ($3,600) – CAR @ NO

Waller is an appealing, low-cost tight end option after a productive Week 9. He caught eight passes for 90 yards and a touchdown against Denver, giving him his best receiving performance of the season. He has also found the end zone four times this year. His recent target involvement makes him an interesting option at only $3,600, especially for DFS players looking to spend more at running back and wide receiver.

FLEX: Woody Marks ($5,700) – HOU @ CLE

Marks has established himself as a consistent part of Houston’s backfield, recording at least 15 rushing attempts in four of his last five games. He has rushed for 70 yards on 18 carries in his most recent outing against the Chargers and has also contributed as a receiver. His workload gives him a reasonable floor for a FLEX option, although his limited touchdown production has kept his fantasy ceiling in check.

DST: Jacksonville Jaguars ($4,000) – JAX @ TEN

Jacksonville is a worthwhile defense to target at $4,000. The Jaguars face a Tennessee offense that could give them opportunities to generate pressure and create turnovers. Jacksonville has also been particularly strong against the run, allowing just 68.3 rushing yards per game through eight games, the second-lowest mark in the NFL. That ability to limit opposing rushing attacks gives the Jaguars a solid foundation for this DFS spot.