How to Bet NFL Season Opener Bills vs Rams

By Chris Amberley in NFL Football
Updated: April 12, 2023 at 1:11 pm EDTPublished:

- The 2022 NFL season kicks off on Thursday, September 8 as the Buffalo Bills visit the LA Rams as 2-point favorites
- There are plenty of ways to bet on this game, and some amazing promos from online sportsbooks to take advantage of
- Read below for more information on how to bet the Bills vs Rams season opener
The NFL season, aka the best season, is finally here. The 2022 campaign officially gets underway on Thursday night when the defending Super Bowl champion Los Angeles Rams host the Buffalo Bills.
There’s a variety of ways you can bet on this game. And some incredible bonus offers from online sportsbooks to take advantage of. All the pertinent information is laid out below, so keep reading to find out how to bet the 2022 NFL season opener.
How to Watch Bills vs Rams on Thursday Night Football
The Bills versus Rams showdown is scheduled to kick off on Thursday, September 8 at 8:20 pm ET from SoFi Stadium in Inglewood, California. NBC will provide the broadcast coverage nationwide, with Mike Tirico and Cris Collingsworth on play-by-play and color commentating duties.

What are the Bills vs Rams Odds?
As of Thursday morning, the Bills are favored by 2 points, after opening as 2.5-point favorites. Buffalo is priced at -135 on the moneyline, while the Rams can be had at +115 to pull off the upset. The game currently features a total of 51.5, after opening two points higher.
LA… say hello to #BillsMafia#Kickoff2022 pic.twitter.com/1D8cFCWP36
— Sunday Night Football on NBC (@SNFonNBC) September 7, 2022
In terms of the betting action, it’s relatively one-sided in both the spread and total markets. 69% of the against the spread bets and 74% of the ATS money is backing Buffalo. Total wise, 60% of the bets and 63% of the money wagered so far has been on the over.
How to Bet Bills vs Rams Moneyline
- Bills moneyline odds (-135)
- Rams moneyline odds (+115)
A moneyline wager is simply a bet on which team will win the game. In this case, the Bills are favored. That means at their current -135 price, you’d have to bet $135 on Buffalo to win $100.
On the opposite side of the spectrum, the Rams +115 price tag means you’d win $115 on a $100 Los Angeles moneyline wager should they emerge victorious.
The Rams kick off the season against the Bills this Thursday.
Will McVay make himself 6-0? pic.twitter.com/CqgsoClY67
— FOX Sports: NFL (@NFLonFOX) September 7, 2022
It’s worth noting that reigning Super Bowl champions are 14-2 in the last 16 season openers on Thursday nights. The Rams are 5-0 in season debuts under Sean McVay in NFL Week 1 trends. While the Bills dropped their opening game of 2021 as a big favorite versus the Steelers.
How to Bet Bills vs Rams Over/Under
An over/under bet is a wager on whether or not the two teams will combine to score more or less than the game’s total. Thursday’s Bills vs Rams over/under is listed at 51.5. This means if they score 51 points or less the “under” bets win. And if they score 52 points or more the “over” bets win.
Just four of LA’s final 14 games of 2021 produced a total north of 51. But 11 of Buffalo’s final 17 contests of 2021 cleared 52 points. The last time these two teams met, Buffalo won a 35-32 decision in 2020.
What Is the Bills vs Rams Spread?
A spread bet refers to how many points a team must win or lose by for the bettors who pick them to win. As mentioned earlier, the Bills are favored by two points. This means they have to win by three or more points to pay out any wager placed on them at -2. Should they win by exactly 2 points, the bet will be refunded.
#RamsHouse have the toughest schedule this season based on opponent win %.
It all starts with #Kickoff2022 when #BillsMafia heads to LA. pic.twitter.com/Yoi8eZvEZE
— Sunday Night Football on NBC (@SNFonNBC) September 7, 2022
On the other side, the underdog Rams are getting two points. That means a bettor who wagers on them at +2 will win their bet if LA wins outright, or losses by a single point.
Buffalo was the seventh most profitable team to bet against the spread last season, going 10-7-2.
Best Bills vs Rams Betting Promos
And finally, what you’ve all been waiting for. The free money. Online sportsbooks are going above and beyond to attract new customers for the NFL season, and you can take advantage of their generosity to pad your bankroll.
Let’s start with this DraftKings Sportsbook promo code. At DK you can win $200 instantly just by placing a $5 bet. All you have to do is register for a new DraftKings Sportsbook account and place a $5 wager on any Week 1 NFL game. The best part is, it doesn’t matter if your wager wins or losses you still get credited with $200.
By using the FanDuel promo code you can also scoop up $150 by placing a $5 bet on any NFL Week 1 game. You’ll claim that bonus no matter if your wager wins or loses.
Over to this Barstool Sportsbook promo code, where a $20 bet will net you $150 if a touchdown is scored on Thursday. Just sign up for a new account and use code “DIMEFOOTBALL150” to qualify.
Last but not least, the BetMGM promo code is offering a similar promo. Open up a new account there you’ll qualify to win $200 on a $10 bet if either the Bills or Rams score a touchdown.

Sports Writer
As SBD's resident Swiss Army Knife, Chris covers virtually every sport including NFL, PGA, NBA, MLB, NCAAB, NCAAF and the Olympics. A true grinder, he'd rather pick off small edges in the player props market than swing for the fences with a 5-leg parlay.